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  • Crosses, Genetic  (2)
  • analgesia  (2)
  • 1
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    In silico mapping of complex disease-related traits in mice (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-09
    Description: Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grupe, A -- Germer, S -- Usuka, J -- Aud, D -- Belknap, J K -- Klein, R F -- Ahluwalia, M K -- Higuchi, R -- Peltz, G -- 1 R01 HG02322-01/HG/NHGRI NIH HHS/ -- R01 AR044659/AR/NIAMS NIH HHS/ -- R01 AR044659-07/AR/NIAMS NIH HHS/ -- T32HG-00044/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 8;292(5523):1915-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Genomics, Roche Bioscience, Palo Alto, CA 94303, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11397946" target="_blank"〉PubMed〈/a〉
    Keywords: *Algorithms ; Animals ; Bone Density ; Chromosome Mapping/*methods ; Crosses, Genetic ; Databases, Factual ; *Disease Models, Animal ; Female ; Genetic Linkage ; Genotype ; Humans ; Linkage Disequilibrium ; Major Histocompatibility Complex/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Phenotype ; Polymerase Chain Reaction ; *Polymorphism, Single Nucleotide ; *Quantitative Trait, Heritable ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regulation of bone mass in mice by the lipoxygenase gene Alox15 (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Robert F -- Allard, John -- Avnur, Zafrira -- Nikolcheva, Tania -- Rotstein, David -- Carlos, Amy S -- Shea, Marie -- Waters, Ruth V -- Belknap, John K -- Peltz, Gary -- Orwoll, Eric S -- AR44659/AR/NIAMS NIH HHS/ -- HG02322/HG/NHGRI NIH HHS/ -- R01 AR044659/AR/NIAMS NIH HHS/ -- R01 AR044659-08/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):229-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. kleinro@ohsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonate 12-Lipoxygenase/*genetics/*metabolism ; Arachidonate 15-Lipoxygenase/*genetics/*metabolism ; Bone Density/drug effects/*genetics ; Bone Marrow Cells/metabolism ; Cell Differentiation ; Cells, Cultured ; Crosses, Genetic ; Enzyme Inhibitors/pharmacology ; Female ; Fluorenes/pharmacology ; Gene Expression Profiling ; Genetic Linkage ; Kidney/metabolism ; Lipoxygenase Inhibitors ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Osteoblasts/cytology/metabolism/physiology ; Osteogenesis ; Osteoporosis/enzymology ; Polymorphism, Genetic ; Quantitative Trait Loci ; Rats ; Receptors, Cytoplasmic and Nuclear/metabolism ; Stromal Cells/metabolism ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Selective breeding for high and low levels of opiate-induced analgesia in mice (1983)
    Springer
    Behavior genetics 13 (1983), S. 383-396 
    Details
    ISSN: 1573-3297
    Keywords: mice ; selective breeding ; selection ; analgesia ; antinociception ; levorphanol ; morphine ; hot plate test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h 2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realizedh 2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065776
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  • 4
    Electronic Resource
    Electronic Resource
    Inbred strain differences in morphine-induced analgesia with the hot plate assay: A reassessment (1990)
    Springer
    Behavior genetics 20 (1990), S. 333-338 
    Details
    ISSN: 1573-3297
    Keywords: DBA/2J ; C57BL/6J ; C3H/HeJ ; morphine ; analgesia ; hot plate assay ; genetics ; opioid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Using the hot plate assay of analgesia, several investigators have reported DBA/2J mice to be much more sensitive to morphine and other opioids than C57BL/6J mice using paw-lick as the behavioral end point. In the present studies, we compared DBA/2J, C57BL/6J, and C3H/HeJ mice on two behavioral end points, either (1) the initial response to the hot plate, either a hind paw-lift, paw-shake, or paw-lick, whichever occurred first, or (2) the paw-lick response. In response to either morphine or saline, all three strains showed roughly equivalent latencies to the initial response, but the DBA/2J strain was markedly slow to show paw-lick as a nocifensive response compared to the C57BL/6J strain. As a result, only for the paw-lick response were there significant differences among the three inbred strains in morphine analgesia. Thus, differences in analgesic sensitivity among these strains are largely a function of the behavioral end point used to assess nociception to the hot plate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067800
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