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  • 1
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    The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-10-20
    Description: The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellentin, J D -- Murre, C -- Donlon, T A -- McCaw, P S -- Smith, S D -- Carroll, A J -- McDonald, M E -- Baltimore, D -- Cleary, M L -- CA30969/CA/NCI NIH HHS/ -- CA42106/CA/NCI NIH HHS/ -- CA42971/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1989 Oct 20;246(4928):379-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University School of Medicine, CA 94025.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2799390" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Chromosome Mapping ; *Chromosomes, Human, Pair 1 ; *Chromosomes, Human, Pair 19 ; DNA-Binding Proteins/*genetics ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Transcription Factors/*genetics ; Translocation, Genetic/*physiology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Quantitative trait locus for reading disability on chromosome 6 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-10-14
    Description: Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi 2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi 2 = 27.35, P 〈 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardon, L R -- Smith, S D -- Fulker, D W -- Kimberling, W J -- Pennington, B F -- DeFries, J C -- HD-11681/HD/NICHD NIH HHS/ -- HD-27802/HD/NICHD NIH HHS/ -- HG-00085/HG/NHGRI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Oct 14;266(5183):276-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Health Sciences Program, SRI International, Menlo Park, CA 94025.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7939663" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Alleles ; Child ; Chromosome Mapping ; *Chromosomes, Human, Pair 6 ; Diseases in Twins/*genetics ; Dyslexia/*genetics ; Female ; Genetic Linkage ; Genetic Markers ; HLA Antigens/genetics ; Humans ; Major Histocompatibility Complex ; Male ; Nuclear Family ; Regression Analysis ; Twins, Dizygotic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-10
    Description: The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039561/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039561/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manganas, Louis N -- Zhang, Xueying -- Li, Yao -- Hazel, Raphael D -- Smith, S David -- Wagshul, Mark E -- Henn, Fritz -- Benveniste, Helene -- Djuric, Petar M -- Enikolopov, Grigori -- Maletic-Savatic, Mirjana -- 5K08 NS044276/NS/NINDS NIH HHS/ -- K08 NS044276/NS/NINDS NIH HHS/ -- K08 NS044276-01/NS/NINDS NIH HHS/ -- R01 NS032764/NS/NINDS NIH HHS/ -- R01-NS32764/NS/NINDS NIH HHS/ -- R21 NS053875/NS/NINDS NIH HHS/ -- R21 NS053875-01A1/NS/NINDS NIH HHS/ -- R21NS05875-1/NS/NINDS NIH HHS/ -- T32DK07521-16/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):980-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SUNY Stony Brook, Stony Brook, NY 11794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991865" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Adult Stem Cells/chemistry/*cytology ; Algorithms ; Animals ; Biomarkers/analysis/chemistry ; Brain/cytology/embryology ; Brain Chemistry ; Cell Differentiation ; Child ; Embryonic Stem Cells/chemistry/cytology ; Fatty Acids/*analysis/chemistry ; Female ; Hippocampus/chemistry/*cytology ; Humans ; Magnetic Resonance Spectroscopy/*methods ; Male ; Mice ; Neurons/chemistry/*cytology ; Protons ; Rats ; Signal Processing, Computer-Assisted ; Stem Cells/chemistry/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-10
    Description: An inversion of chromosome 14 present in the tumor cells of a patient with childhood acute lymphoblastic leukemia of B-cell lineage was shown to be the result of a site-specific recombination event between an immunoglobulin heavy-chain variable gene and the joining segment of a T-cell receptor alpha chain. This rearrangement resulted in the formation of a hybrid gene, part immunoglobulin and part T-cell receptor. Furthermore, this hybrid gene was transcribed into messenger RNA with a completely open reading frame. Thus, two loci felt to be normally activated at distinct and disparate points in lymphocyte development were unified and expressed in this tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denny, C T -- Hollis, G F -- Hecht, F -- Morgan, R -- Link, M P -- Smith, S D -- Kirsch, I R -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):197-200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3092355" target="_blank"〉PubMed〈/a〉
    Keywords: *B-Lymphocytes ; Cell Differentiation ; Child ; *Chromosome Inversion ; Chromosomes, Human, 13-15 ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Leukemia, Lymphoid/*genetics/pathology ; Models, Genetic ; Receptors, Antigen, T-Cell/*genetics ; Recombination, Genetic ; T-Lymphocytes ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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