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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of human α-thrombin with artificial surfaces and reactivity of adsorbed α-thrombin (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 467-476 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Thrombin adsorbed onto Cuprophane or poly(vinyl chloride) (PVC) was shown to be inactive with respect to amidase activity. Desorbed thrombin from these two artificial surfaces showed only low amidase activity. However, in the presence of albumin, the surface-bound thrombin appeared to exhibit increased amidase activity. This apparent activity may be due to the action of thrombin displaced from the surfaces by albumin. Thrombin bound to Cuprophane or PVC was shown to be capable of reacting with antithrombin III (AT III) only in the presence of heparin. On the other hand, AT III bound to Cuprophane or PVC was unable to react with thrombin in either the absence or presence of heparin. Fibrin formation on or at surfaces was demonstrated by phase contrast microscopy when Cuprophane or PVC pretreated with thrombin and carefully rinsed was incubated in a fibrinogen solution. This fibrin formation is time dependent and likely is the result of direct interaction of adsorbed thrombin with fibrinogen in solution. Glass, Cuprophane, and PVC pretreated with thrombin were shown to attract more platelets than respective untreated surfaces. The enhancing effect of adsorbed thrombin on platelet adhesion was similar to the enhancing effect of adsorbed fibrinogen. Thrombin adsorbed onto PVC and crosslinked by glutaraldehyde treatment was shown to be antigenically active with a 125I-labeled monospecific antithrombin IgG produced in rabbits. No other plasma proteins adsorbed singly or from plasma or serum onto PVC reacted significantly with the antithrombin IgG preparation. The possible significance of these observations is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140413
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  • 2
    Electronic Resource
    Electronic Resource
    SEM analysis of copper-containing intrauterine implants (1981)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 15 (1981), S. 605-610 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820150414
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  • 3
    Electronic Resource
    Electronic Resource
    Organotin(IV) derivatives of mercaptosuccinic and thiodiacetic acids (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 7 (1993), S. 33-38 
    Details
    ISSN: 0268-2605
    Keywords: Organotin(IV) ; mercaptosuccinic acid ; thiodiacetic acid ; complexes ; structures ; Sn—S bonding ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Di- and tri-organotin(IV) complexes of general formula R2SnAH, (R3Sn)2AH, R2SnB, (R3Sn)2B (A=dianion of mercaptosuccinic acid; B=dianion of thiodiacetic acid; R=Me, Et, nPr, nBu, nOct in R2Sn and nBu in R3Sn) have been synthesized and characterized by elemental analysis, IR and 1H and 13C NMR spectroscopy. These data support the preferential binding of sulphur over carboxylate by tin(IV) in R2SnAH and (R3Sn)2AH. R2SnAH complexes are assigned pentacoordinated bridged polymeric trigonal bipyramidal geometry whereas (R3Sn)2AH complexes are monomeric with trigonal bipyramidal geometry at tin arising from a bidentate carboxylate group at one tin atom and from weak bonding via Sn←O=C at the other tin atom. In R2SnB and (R3Sn)2B, tin(IV) binds to two carboxylate groups in a unidentate and a bidentate manner respectively, resulting in tetracoordinated and pentacoordinated structures. Potential uses of these compounds are discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aoc.590070103
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  • 4
    Electronic Resource
    Electronic Resource
    Diorganotin(IV) complexes of indole 3-acetic acid (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 7 (1993), S. 39-43 
    Details
    ISSN: 0268-2605
    Keywords: Diorganotin(IV) ; indole 3-acetic acid ; biocidal activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Alkyl derivatives of indole 3-acetic acid (IAA) have been prepared and are suitable for investigating steric substituent effects on hormonal activity without major interference from electronic effects. Triorganotin(IV) derivatives of indole 3-acetic acid and N-methylindole 3-acetic acid have been reported to act as insecticidal, fungicidal and bactericidal agents. Me3SnIAA is more active as a biocide than Cy3SnIAA. The activity of these two compounds may be due to the fact that four-coordinated tin monomers or five-coordinated tin polymers are often more active than chelated five-coordinated tin species because these readily undergo hydrolysis to give R3Sn(H2O+)2 species. The ligand affects the rate of formation of the ligand-free active organotin entity. Biocidal activity is expected from diorganotin(IV) pentacoordinated complexes of indole 3-acetic acid in the present case due to (i) the activity of pentacoordinated organotin species, (ii) the presence of an - NH moiety in the complexes, which is an active site for binding. The NH moiety may be deprotonated and nitrogen may coordinate with metal ions present in the physiological systems and thus destroy the activity of enzymes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aoc.590070104
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of Macrocyclic Compounds Using Diorganotin(IV) Dicarboxylates as Covalent Templates (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 10 (1996), S. 363-367 
    Details
    ISSN: 0268-2605
    Keywords: diorganotin(IV) ; covalent templates ; macrocyclic ; acid anhydrides ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of new macrocyclic compounds have been prepared by treating di-n-butyltin(IV) dicarboxylates of diphenic acid (biphenyl-2,2′-dicarboxylic acid), thiodiacetic acid and maleic anhydride with succinyl, adipoyl and sebacoyl dichlorides. The compounds have been characterized with the help of elemental analyses and spectral data (mass, IR, IH and 13C NMR).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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