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  • 1
    Electronic Resource
    Electronic Resource
    Biologically Active Glycosides from Asteroidea, 36. Re-examination of the Structure of Acanthaganglioside C, and the Identification of Three Minor Acanthagangliosides F, G and H (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 931-936 
    Details
    ISSN: 0947-3440
    Keywords: Gangliosides ; Acanthagangliosides ; Starfish ; Acanthaster planci ; N M R spectroscopy ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure of acanthaganglioside C (1) has been re-examined using MQ-COSY, TOCSY, NOESY, HSQC, HMBC and HSQC-TOCSY experiments. As a result, it is clarified that N-acetyl neuraminic acid (NeuAc) is linked to the C-3 position, and not the C-4 position, of the β-galactopyranose. In addition, three minor acanthagangliosides, F (2), G (3) and H (4), have also been isolated from the ganglioside molecular species AG-2. Their structures have been determined on the basis of chemical and spectroscopic evidence.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970522
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  • 2
    Electronic Resource
    Electronic Resource
    Biodegradability of poly(vinyl acetate) containing a pyridinium group (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 56 (1995), S. 509-516 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An attempt has been made to give biodegradability to poly(vinyl acetate) by partial modification of the chemical structure. Poly(vinyl acetate) containing a small amount of N-benzyl-4-vinylpyridinium chloride (PVAc-co-VPC) and that containing 16 mol % of methyl acrylate and a small amount of the pyridinium group (PVAc-co-MA-co-VPC) showed significant degradation when placed in an aeration tank of sewage works. Control polymers possessed of no pyridinium group did not show significant degradation under these conditions, and the extent of weight reduction during the treatment increased with the content of the pyridinium group. The weight reduction exhibited an uppermost limit after 7 days of the treatment, and the pyridinium group disappeared from the polymer during the early period. Incorporation of the pyridinium group into poly(vinyl acetate) appeared to have improved the biodegradability. Gel permeation chromatographic analysis showed that the low molecular weight fraction was more easily degraded than was the high molecular weight fraction. In the degradation of PVAc-co-MA-co-VPC, the unit of methyl acrylate was more easily removed than that of vinyl acetate. © 1995 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070560413
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  • 3
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    Large-scale shell model study of the newly found isomer in ^{136} La (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-07-22
    Description: Author(s): E. Teruya, N. Yoshinaga, K. Higashiyama, H. Nishibata, A. Odahara, and T. Shimoda The doubly-odd nucleus La 136 is theoretically studied in terms of a large-scale shell model. The energy spectrum and transition rates are calculated and compared with the most updated experimental data. The isomerism is investigated for the first 14 + state, which was found to be an isomer in the pre… [Phys. Rev. C 94, 014317] Published Thu Jul 21, 2016
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Large-scale shell-model calculations of nuclei around mass 210 (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-07-01
    Description: Author(s): E. Teruya, K. Higashiyama, and N. Yoshinaga Large-scale shell-model calculations are performed for even-even, odd-mass, and doubly odd nuclei of Pb, Bi, Po, At, Rn, and Fr isotopes in the neutron deficit region ( Z ≥ 82 , N ≤ 126 ) assuming Pb 208 as a doubly magic core. All the six single-particle orbitals between the magic numbers 82 and 126, namely… [Phys. Rev. C 93, 064327] Published Thu Jun 30, 2016
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Shell-model calculations of nuclei around mass 130 (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-09-24
    Description: Author(s): E. Teruya, N. Yoshinaga, K. Higashiyama, and A. Odahara Shell-model calculations are performed for even-even, odd-mass, and doubly-odd nuclei of Sn, Sb, Te, I, Xe, Cs, and Ba isotopes around mass 130 using the single-particle space made up of valence nucleons occupying the 0 g 7 / 2 , 1 d 5 / 2 , 2 s 1 / 2 , 0 h 11 / 2 , and 1 d 3 / 2 orbitals. The calculated energies and electrom… [Phys. Rev. C 92, 034320] Published Mon Sep 21, 2015
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Medium-spin states in ^{135}Cs (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-12-13
    Description: Author(s): N. Fotiades, J. A. Cizewski, K. Higashiyama, N. Yoshinaga, E. Teruya, R. Krücken, R. M. Clark, P. Fallon, I. Y. Lee, A. O. Macchiavelli, and W. Younes Limited information is currently known on medium- and higher-spin states for 135 Cs, a neutron-rich nucleus amenable to shell-model calculations due to its proximity to the shell closures in 132 Sn. In order to extend the level structure of 135 Cs to higher excitations, this nucleus was studied via pro... [Phys. Rev. C 88, 064315] Published Thu Dec 12, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-20
    Description: Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss of tumour suppressor genes is thought to critically depend on induction of the p19(Arf)-p53 pathway. The Skp2 E3-ubiquitin ligase can act as a proto-oncogene and its aberrant overexpression is frequently observed in human cancers. Here we show that although Skp2 inactivation on its own does not induce cellular senescence, aberrant proto-oncogenic signals as well as inactivation of tumour suppressor genes do trigger a potent, tumour-suppressive senescence response in mice and cells devoid of Skp2. Notably, Skp2 inactivation and oncogenic-stress-driven senescence neither elicit activation of the p19(Arf)-p53 pathway nor DNA damage, but instead depend on Atf4, p27 and p21. We further demonstrate that genetic Skp2 inactivation evokes cellular senescence even in oncogenic conditions in which the p19(Arf)-p53 response is impaired, whereas a Skp2-SCF complex inhibitor can trigger cellular senescence in p53/Pten-deficient cells and tumour regression in preclinical studies. Our findings therefore provide proof-of-principle evidence that pharmacological inhibition of Skp2 may represent a general approach for cancer prevention and therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928066/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928066/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Hui-Kuan -- Chen, Zhenbang -- Wang, Guocan -- Nardella, Caterina -- Lee, Szu-Wei -- Chan, Chia-Hsin -- Yang, Wei-Lei -- Wang, Jing -- Egia, Ainara -- Nakayama, Keiichi I -- Cordon-Cardo, Carlos -- Teruya-Feldstein, Julie -- Pandolfi, Pier Paolo -- R01 CA082328/CA/NCI NIH HHS/ -- R01 CA082328-13/CA/NCI NIH HHS/ -- R01 MD004038/MD/NIMHD NIH HHS/ -- England -- Nature. 2010 Mar 18;464(7287):374-9. doi: 10.1038/nature08815.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237562" target="_blank"〉PubMed〈/a〉
    Keywords: Activating Transcription Factor 4/metabolism ; Adenovirus E1A Proteins/genetics/metabolism ; Animals ; *Cell Aging/drug effects ; *Cell Transformation, Neoplastic/drug effects ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16/deficiency/genetics/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Fibroblasts ; Male ; Mice ; PTEN Phosphohydrolase/deficiency/genetics/metabolism ; Prostate/cytology/metabolism ; Prostatic Neoplasms/drug therapy/pathology/prevention & control ; Proto-Oncogene Proteins p21(ras)/genetics/metabolism ; S-Phase Kinase-Associated Proteins/antagonists & inhibitors/genetics/*metabolism ; SKP Cullin F-Box Protein Ligases/metabolism ; Tumor Suppressor Protein p53/deficiency/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-05-15
    Description: Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978506/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978506/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Takahiro -- Merghoub, Taha -- Hobbs, Robin M -- Dong, Lin -- Maeda, Manami -- Zakrzewski, Johannes -- van den Brink, Marcel R M -- Zelent, Arthur -- Shigematsu, Hirokazu -- Akashi, Koichi -- Teruya-Feldstein, Julie -- Cattoretti, Giorgio -- Pandolfi, Pier Paolo -- CA-102142/CA/NCI NIH HHS/ -- R01 CA102142/CA/NCI NIH HHS/ -- R01 CA102142-06A1/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2007 May 11;316(5826):860-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17495164" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*cytology/physiology ; Bone Marrow Cells/cytology ; Cell Lineage ; Cells, Cultured ; DNA-Binding Proteins/*genetics/physiology ; Gene Deletion ; Hematopoietic Stem Cells/*cytology/physiology ; *Lymphopoiesis ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Biological ; *Proto-Oncogenes ; Receptors, Notch/*metabolism ; Signal Transduction ; T-Lymphocytes/*cytology/physiology ; Thymus Gland/cytology ; Transcription Factors/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Octupole phonon model based on the shell model for octupole vibrational states (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-10-30
    Description: Author(s): N. Yoshinaga, K. Yanase, K. Higashiyama, and E. Teruya A model is proposed for a description of the octupole vibrational states based on the nuclear shell model. In this model, a one-octupole-phonon representing the collective octupole vibration across the magic core is introduced onto the shell-model states that are microscopically calculated within th... [Phys. Rev. C 98, 044321] Published Mon Oct 29, 2018
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Nuclear Schiff moments for the lowest 1/2^{+} states in Xe isotopes (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-04-26
    Description: Author(s): N. Yoshinaga, K. Higashiyama, R. Arai, and E. Teruya The electric dipole moment of a neutral atom is mainly induced by the nuclear Schiff moment. The nuclear wave functions beyond mean-field theories are calculated in terms of the nuclear shell model, which contains two-body interactions violating parity and time-reversal invariance. Using wave functi... [Phys. Rev. C 87, 044332] Published Thu Apr 25, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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