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  • 1
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    Signal transduction through prion protein (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-16
    Description: The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1-dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mouillet-Richard, S -- Ermonval, M -- Chebassier, C -- Laplanche, J L -- Lehmann, S -- Launay, J M -- Kellermann, O -- New York, N.Y. -- Science. 2000 Sep 15;289(5486):1925-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Differenciation Cellulaire, CNRS-Institut Pasteur, 75724 Paris Cedex 15, France. srichard@pasteur.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10988071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caveolin 1 ; *Caveolins ; Cell Compartmentation ; Cell Differentiation ; Enzyme Activation ; Membrane Proteins/metabolism ; Mice ; Neurons/cytology/metabolism ; PrPC Proteins/*metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-fyn ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-09-18
    Description: The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression. In mice, chronic treatment with the SSRI fluoxetine (Prozac) increases miR-16 levels in serotonergic raphe nuclei, which reduces SERT expression. Further, raphe exposed to fluoxetine release the neurotrophic factor S100beta, which acts on noradrenergic cells of the locus coeruleus. By decreasing miR-16, S100beta turns on the expression of serotonergic functions in noradrenergic neurons. Based on pharmacological and behavioral data, we propose that miR-16 contributes to the therapeutic action of SSRI antidepressants in monoaminergic neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baudry, Anne -- Mouillet-Richard, Sophie -- Schneider, Benoit -- Launay, Jean-Marie -- Kellermann, Odile -- New York, N.Y. -- Science. 2010 Sep 17;329(5998):1537-41. doi: 10.1126/science.1193692.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20847275" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Animals ; Antidepressive Agents, Second-Generation/administration & ; dosage/metabolism/*pharmacology ; Cell Line ; Depression ; Fluoxetine/administration & dosage/metabolism/*pharmacology ; HeLa Cells ; Humans ; Locus Coeruleus/metabolism ; Mice ; MicroRNAs/administration & dosage/genetics/*metabolism ; Nerve Growth Factors/metabolism ; Neurons/drug effects/*metabolism ; Norepinephrine/metabolism ; Protein Biosynthesis ; Raphe Nuclei/drug effects/*metabolism ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins/metabolism ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/*genetics/metabolism ; Serotonin Uptake Inhibitors/administration & dosage/metabolism/*pharmacology ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    The human serotonin 5-HT2B receptor: Pharmacological link between 5-HT2 and 5-HT1D receptors
    Amsterdam : Elsevier
    FEBS Letters 352 (1994), S. 393-399 
    Details
    ISSN: 0014-5793
    Keywords: Cardiovascular system ; DOI binding ; G protein-coupled receptor ; Polymerase chain reaction ; cDNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00968-6
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    Paper (German National Licenses)
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