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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 27 (1999), S. 746-757 
    ISSN: 1573-9686
    Keywords: G-Proteins ; Pacemaking ; Ach inhibition ; ACh diffusion ; Calmodulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract This work is concerned with modeling the key interrelated biochemical reactions involved in initiating and inhibiting pacemaking activity in the mammalian sinoatrial node. A detailed model involving G-proteins was developed to better represent the activation pathway for adenylate cyclase. Concentration profiles of an activated G-protein complex [αTC] were established as a function of the membrane bound calcium calmodulin concentration. A previously developed model used to establish temporal profiles of cAMP was improved using the G-protein effects through the [αTC] functionality. Methods were also developed to model inhibition of G-protein by acetylcholine. Analytical solutions were developed to predict acetylcholine concentration profiles as a function of diffusion parameter and duration of acetylcholine pulses. The model was used to demonstrate suppression of cAMP by acetylcholine through G-protein pathways. It provides a basis for a tool to quantify key biochemical species during stimulation and inhibition of sinoatrial node pacemaking. A stability analysis of the model equations has potential application in studying the link between the biochemical species concentrations and abnormal effects in sinoatrial node pacemaking. © 1999 Biomedical Engineering Society. PAC99: 8710+e, 8714Ee, 8719Nn, 8719Hh, 8717Aa
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 21 (1993), S. 669-677 
    ISSN: 1573-9686
    Keywords: Channel ; Phosphorylation ; Calmodulin ; Membrane ; Electrostatics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Consideration of the enzymatic reactions governing calcium channel phosphorylation and dephosphorylation leads one to deduce that there exist separate groups of enzymes, membrane-bound and cytoplasmic, that are activated by a common mediator, calmodulin (CaM), whose time-dependent appearance (via diffusion) at both locales is controlled by both intracellular calcium levels and electrostatic interaction with the membrane. In brief, the change in the sign and extent of the electrical charge borne by the modulator in the presence of calcium (Ca) brings about the electrostatic attraction that enables the transport of [Ca−CaM] to the membrane. This translocation of Ca−CaM makes possible a sequential activation of cellular enzymes whose locations differ. The sequence, both spatial and temporal, of the activation of various cellular enzymes by Ca−CaM appears to be a control network shared in common by excitable cells containing a stimulus-response pathway mediated by second messengers.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2022-06-07
    Description: Abstract
    Description: This data was collected to write an extensive review on organic compounds in geothermal fluids as part of the REFLECT (Redefining geothermal fluid properties at extreme conditions to optimize future geothermal energy extraction). The data is mainly focussed on geothermal sites were organic compound data was reported in the literature. It includes data from the literature (Feldbusch, 2016; Vetter, 2012; Brehme et al., 2019; Westphal et al., 2019; Sanjuan et al., 2016) as well as own data that was analysed at the GFZ German Research Centre for Geosciences in section 3.2 (Organic Geochemistry). It comprises 130 samples from 19 different sites including DOC, organic acid anion as well as main inorganic anion concentrations, well depths, and reservoir temperatures of various geothermal sites in Europe. Due to confidentiality agreements Site names are all given in ID’s which are fully explained in the publication “Organic compounds in geothermal fluids – a review” when available. Sample ID’s are also given if the samples, both from the literature or own samples were measured at GFZ German Research Centre for Geosciences. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement nº 850626 (REFLECT).
    Keywords: Geothermal fluids ; Brine ; Dissolved organic matter ; Dissolved organic carbon ; Inhibitor ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOCHEMISTRY ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOCHEMISTRY 〉 GEOCHEMICAL PROPERTIES 〉 CHEMICAL CONCENTRATIONS ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOTHERMAL DYNAMICS 〉 GEOTHERMAL ENERGY
    Type: Dataset , Dataset
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  • 4
    Publication Date: 2023-04-27
    Description: Abstract
    Description: This dataset comprises 47 fluid samples from 11 geothermal sites (Germany, Austria, Iceland, Turkey, Netherlands, Belgium, French West Indies). The samples were collected within the REFLECT project (Redefining geothermal properties at extreme conditions to optimize future geothermal energy extraction). The focus with these analyses were on the organic compound composition of the fluids, since they are rarely included in the analyses of fluids taken from geothermal power plants. Understanding the organic compound composition of geothermal fluids might help to better understand chemical reactions within the fluids and might help to mitigate problems that arise with the operation of a geothermal power plant such as mineral precipitation (scaling) and corrosion of the casing and pipes.
    Description: Methods
    Description: The samples were taken by the onsite project partners and sent to GFZ for the analyses. Generally, the fluid samples were taken at the surface instalments and remained untreated after sampling (otherwise given as remark in the datasheet). Sampling bottles were rinsed and flushed with the fluids prior to filling them up. Sampling volumes ranged from 250-500 ml per sample.
    Keywords: Geothermal fluids ; Brine ; Dissolved organic matter ; Dissolved organic carbon ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOCHEMISTRY ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOCHEMISTRY 〉 GEOCHEMICAL PROPERTIES 〉 CHEMICAL CONCENTRATIONS ; EARTH SCIENCE 〉 SOLID EARTH 〉 GEOTHERMAL DYNAMICS 〉 GEOTHERMAL ENERGY
    Type: Dataset , Dataset
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