Publication Date:
2000-01-15
Description:
Although gammadelta T cells are implicated in regulating immune responses, gammadelta T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the gammadelta T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory gammadelta T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gammadelta T cell activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowley, M P -- Fahrer, A M -- Baumgarth, N -- Hampl, J -- Gutgemann, I -- Teyton, L -- Chien, Y -- AI33431/AI/NIAID NIH HHS/ -- AI34762-34/AI/NIAID NIH HHS/ -- AI42267/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):314-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Immunology, Department of Microbiology and Immunology, and Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10634788" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CHO Cells
;
Cricetinae
;
Dimerization
;
Histocompatibility Antigens Class I/*immunology/metabolism
;
Ligands
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Proteins/*immunology/metabolism
;
Receptors, Antigen, T-Cell, alpha-beta/immunology/metabolism
;
Receptors, Antigen, T-Cell, gamma-delta/*immunology/metabolism
;
Spleen/cytology/immunology
;
T-Lymphocyte Subsets/*immunology
;
beta 2-Microglobulin/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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