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  • 1
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    Cholecystokinin inhibits tail pinch-induced eating in rats (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nemeroff, C B -- Osbahr, A J 3rd -- Bissette, G -- Jahnke, G -- Lipton, M A -- Prange, A J -- New York, N.Y. -- Science. 1978 May 19;200(4343):793-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565535" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Bradykinin/pharmacology ; Cholecystokinin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Humans ; Male ; Peptide Fragments/pharmacology ; Rats ; Stress, Psychological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Erythrosine (Red No. 3) and its nonspecific biochemical actions: what relation to behavioral changes? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control of 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Ferris, R M -- Tang, F L -- Vogel, R A -- Kilts, C D -- Lipton, M A -- Smith, D A -- Mueller, R A -- Breese, G R -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Biological Transport/drug effects ; Brain/*drug effects/metabolism ; Dopamine/*metabolism ; Food Coloring Agents/*pharmacology ; Hydroxydopamines/pharmacology ; Male ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Rats ; Synaptosomes/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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