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  • 1
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    Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-19
    Description: The evolutionarily conserved Wnt/Wingless signal transduction pathway directs cell proliferation, cell fate, and cell death during development in metazoans and is inappropriately activated in several types of cancer. The majority of colorectal carcinomas contain truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor, a negative regulator of Wnt/Wingless signaling. Here, we demonstrate that Drosophila Apc homologs also have an activating role in both physiological and ectopic Wingless signaling. The Apc amino terminus is important for its activating function, whereas the beta-catenin binding sites are dispensable. Apc likely promotes Wingless transduction through down-regulation of Axin, a negative regulator of Wingless signaling. Given the evolutionary conservation of APC in Wnt signal transduction, an activating role may also be present in vertebrates with relevance to development and cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takacs, Carter M -- Baird, Jason R -- Hughes, Edward G -- Kent, Sierra S -- Benchabane, Hassina -- Paik, Raehum -- Ahmed, Yashi -- KO8CA078532/CA/NCI NIH HHS/ -- R01 CA105038/CA/NCI NIH HHS/ -- R01CA105038/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):333-6. doi: 10.1126/science.1151232.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202290" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis ; Armadillo Domain Proteins/metabolism ; Axin Protein ; Binding Sites ; Cytoskeletal Proteins/chemistry/genetics/*metabolism ; Down-Regulation ; Drosophila/genetics/growth & development/*metabolism ; Drosophila Proteins/chemistry/genetics/*metabolism ; Genes, Insect ; Mutation ; Photoreceptor Cells, Invertebrate/cytology ; Proto-Oncogene Proteins/*metabolism ; *Signal Transduction ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/chemistry/genetics/*metabolism ; Wings, Animal/growth & development/metabolism ; Wnt1 Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    A carrier-arraying demonstration at Goldstone for receiving Pioneer 11 signals (1991)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A carrier arraying technique was demonstrated at Goldstone. The Block III receivers of two 34-m antennas, Deep Space Station 12 and 15, were arrayed together to receive S band (2.3 GHz) signals from the Pioneer 11 spacecraft. Carrier phases in the two receivers were synchronized by the analog phase lock loops, and carrier signals were added at an intermediate frequency to enhance tracking performance. The receiver at DSS 15, which has been unable to lock up and track the Pioneer 11 signal by itself due to a wider tracking loop bandwidth and a higher system temperature, was now able to track the carrier and produce usable baseband signals. The receiver at DSS 12 achieved a reduction of the rms phase error, increasing the telemetry symbol SNR by an average of 0.35 dB. The baseband signals from both antennas were then synchronized and combined using the existing Baseband Assembly, thereby achieving a total symbol SNR increase of 2.5 + or - 0.7 dB relative to DSS 12 alone. A more comprehensive model is presented to permit evaluation of both thermal and phase noise effects. The analysis agrees well with observed data.
    Keywords: COMMUNICATIONS AND RADAR
    Type: The Telecommunications and Data Acquisition Report; p 307-334
    Format: text
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    NASA TECHNICAL REPORTS
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