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  • 1
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    Mechanisms of evolution in Rickettsia conorii and R. prowazekii (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: Rickettsia conorii is an obligate intracellular bacterium that causes Mediterranean spotted fever in humans. We determined the 1,268,755-nucleotide complete genome sequence of R. conorii, containing 1374 open reading frames. This genome exhibits 804 of the 834 genes of the previously determined R. prowazekii genome plus 552 supplementary open reading frames and a 10-fold increase in the number of repetitive elements. Despite these differences, the two genomes exhibit a nearly perfect colinearity that allowed the clear identification of different stages of gene alterations with gene remnants and 37 genes split in 105 fragments, of which 59 are transcribed. A 38-kilobase sequence inversion was dated shortly after the divergence of the genus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogata, H -- Audic, S -- Renesto-Audiffren, P -- Fournier, P E -- Barbe, V -- Samson, D -- Roux, V -- Cossart, P -- Weissenbach, J -- Claverie, J M -- Raoult, D -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2093-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Information Genetique & Structurale, CNRS-AVENTIS UMR 1889, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557893" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Chlamydia/genetics ; Computational Biology ; DNA, Bacterial/genetics ; DNA, Intergenic ; *Evolution, Molecular ; Gene Dosage ; Gene Silencing ; Gene Transfer, Horizontal ; Genes, Bacterial ; *Genome, Bacterial ; Open Reading Frames ; Phylogeny ; Polymerase Chain Reaction ; Repetitive Sequences, Nucleic Acid ; Rickettsia/genetics ; Rickettsia conorii/*genetics/physiology ; Rickettsia prowazekii/*genetics/physiology ; Sequence Analysis, DNA ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Comparative genomics of Listeria species (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-27
    Description: Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glaser, P -- Frangeul, L -- Buchrieser, C -- Rusniok, C -- Amend, A -- Baquero, F -- Berche, P -- Bloecker, H -- Brandt, P -- Chakraborty, T -- Charbit, A -- Chetouani, F -- Couve, E -- de Daruvar, A -- Dehoux, P -- Domann, E -- Dominguez-Bernal, G -- Duchaud, E -- Durant, L -- Dussurget, O -- Entian, K D -- Fsihi, H -- Garcia-del Portillo, F -- Garrido, P -- Gautier, L -- Goebel, W -- Gomez-Lopez, N -- Hain, T -- Hauf, J -- Jackson, D -- Jones, L M -- Kaerst, U -- Kreft, J -- Kuhn, M -- Kunst, F -- Kurapkat, G -- Madueno, E -- Maitournam, A -- Vicente, J M -- Ng, E -- Nedjari, H -- Nordsiek, G -- Novella, S -- de Pablos, B -- Perez-Diaz, J C -- Purcell, R -- Remmel, B -- Rose, M -- Schlueter, T -- Simoes, N -- Tierrez, A -- Vazquez-Boland, J A -- Voss, H -- Wehland, J -- Cossart, P -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):849-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomique des Microorganismes Pathogenes, Unite des Interactions Bacteries-Cellules, Service d'Informatique Scientifique, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679669" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Amino Acid Motifs ; Bacillus subtilis/genetics ; Bacterial Proteins/chemistry/*genetics/physiology ; Base Composition ; Carrier Proteins/chemistry/genetics ; Chromosomes, Bacterial/genetics ; DNA, Bacterial/chemistry/genetics ; Gene Transfer, Horizontal ; Genes, Bacterial ; *Genome, Bacterial ; Genomics ; Listeria/chemistry/*genetics/physiology ; Listeria monocytogenes/chemistry/*genetics/pathogenicity/physiology ; Membrane Proteins/chemistry/genetics ; Sequence Analysis, DNA ; Staphylococcus aureus/genetics ; Transcription Factors/chemistry/genetics ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Exploitation of mammalian host cell functions by bacterial pathogens (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: Interest in bacterial pathogenesis has recently increased because of antibiotic resistance, the emergence of new pathogens and the resurgence of old ones, and the lack of effective therapeutics. The molecular and cellular mechanisms of microbial pathogenesis are currently being defined, with precise knowledge of both the common strategies used by multiple pathogenic bacteria and the unique tactics evolved by individual species to help establish infection. What is emerging is a new appreciation of how bacterial pathogens interact with host cells. Many host cell functions, including signal transduction pathways, cytoskeletal rearrangements, and vacuolar trafficking, are exploited, and these are the focus of this review. A bonus of this work is that bacterial virulence factors are providing new tools to study various aspects of mammalian cell functions, in addition to mechanisms of bacterial disease. Together these developments may lead to new therapeutic strategies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finlay, B B -- Cossart, P -- New York, N.Y. -- Science. 1997 May 2;276(5313):718-25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biotechnology Laboratory, University of British Columbia, Vancouver, B.C., Canada, V6T-1Z3. bfinlay@unixg.ubc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Bacteria/genetics/*pathogenicity ; *Bacterial Adhesion ; Bacterial Infections/*microbiology ; Bacterial Physiological Phenomena ; Bacterial Toxins/toxicity ; Cells, Cultured ; Cytoskeleton/physiology ; Epithelial Cells ; Epithelium/microbiology ; Humans ; Phagocytosis ; Signal Transduction ; Vacuoles/microbiology ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The Listeria transcriptional landscape from saprophytism to virulence (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-05-19
    Description: The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (〈500 nucleotides), at least two of which are involved in virulence in mice, we have identified antisense RNAs covering several open-reading frames and long overlapping 5' and 3' untranslated regions. We discovered that riboswitches can act as terminators for upstream genes. When Listeria reaches the host intestinal lumen, an extensive transcriptional reshaping occurs with a SigB-mediated activation of virulence genes. In contrast, in the blood, PrfA controls transcription of virulence genes. Remarkably, several non-coding RNAs absent in the non-pathogenic species Listeria innocua exhibit the same expression patterns as the virulence genes. Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toledo-Arana, Alejandro -- Dussurget, Olivier -- Nikitas, Georgios -- Sesto, Nina -- Guet-Revillet, Helene -- Balestrino, Damien -- Loh, Edmund -- Gripenland, Jonas -- Tiensuu, Teresa -- Vaitkevicius, Karolis -- Barthelemy, Mathieu -- Vergassola, Massimo -- Nahori, Marie-Anne -- Soubigou, Guillaume -- Regnault, Beatrice -- Coppee, Jean-Yves -- Lecuit, Marc -- Johansson, Jorgen -- Cossart, Pascale -- 233348/European Research Council/International -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Jun 18;459(7249):950-6. doi: 10.1038/nature08080. Epub 2009 May 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Pasteur, Unite des Interactions Bacteries-Cellules, F-75015 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19448609" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Gene Expression Regulation, Bacterial ; Genes, Bacterial/genetics ; Genome, Bacterial/genetics ; Intestines/microbiology ; Listeria monocytogenes/*genetics/*pathogenicity ; Mice ; Open Reading Frames/genetics ; Operon/genetics ; RNA, Bacterial/analysis/*genetics ; Regulatory Sequences, Ribonucleic Acid/genetics ; Transcription, Genetic/*genetics ; Untranslated Regions/genetics ; Virulence/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Cellular microbiology emerging (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cossart, P -- Boquet, P -- Normark, S -- Rappuoli, R -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):315-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite des Interactions Bacteries-Cellules, Institut Pasteur, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553065" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Bacteria/*pathogenicity ; Bacterial Physiological Phenomena ; Bacterial Toxins/toxicity ; Cell Membrane/*physiology/ultrastructure ; Cytoskeleton/*physiology ; Endocytosis ; Humans ; Signal Transduction ; Trypanosoma cruzi/*pathogenicity/physiology ; Vacuoles/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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