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  • 1
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    Complete genome sequence of Neisseria meningitidis serogroup B strain MC58 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-10
    Description: The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains coding sequences only for hypothetical proteins. Insights into the commensal and virulence behavior of N. meningitidis can be gleaned from the genome, in which sequences for structural proteins of the pilus are clustered and several coding regions unique to serogroup B capsular polysaccharide synthesis can be identified. Finally, N. meningitidis contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tettelin, H -- Saunders, N J -- Heidelberg, J -- Jeffries, A C -- Nelson, K E -- Eisen, J A -- Ketchum, K A -- Hood, D W -- Peden, J F -- Dodson, R J -- Nelson, W C -- Gwinn, M L -- DeBoy, R -- Peterson, J D -- Hickey, E K -- Haft, D H -- Salzberg, S L -- White, O -- Fleischmann, R D -- Dougherty, B A -- Mason, T -- Ciecko, A -- Parksey, D S -- Blair, E -- Cittone, H -- Clark, E B -- Cotton, M D -- Utterback, T R -- Khouri, H -- Qin, H -- Vamathevan, J -- Gill, J -- Scarlato, V -- Masignani, V -- Pizza, M -- Grandi, G -- Sun, L -- Smith, H O -- Fraser, C M -- Moxon, E R -- Rappuoli, R -- Venter, J C -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1809-15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10710307" target="_blank"〉PubMed〈/a〉
    Keywords: Antigenic Variation ; Antigens, Bacterial/immunology ; Bacteremia/microbiology ; Bacterial Capsules/genetics ; Bacterial Proteins/genetics/physiology ; DNA Transposable Elements ; Evolution, Molecular ; Fimbriae, Bacterial/genetics ; *Genome, Bacterial ; Humans ; Meningitis, Meningococcal/microbiology ; Meningococcal Infections/microbiology ; Molecular Sequence Data ; Mutation ; Neisseria meningitidis/classification/*genetics/*pathogenicity/physiology ; Open Reading Frames ; Operon ; Phylogeny ; Recombination, Genetic ; *Sequence Analysis, DNA ; Serotyping ; Transformation, Bacterial ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-10
    Description: Neisseria meningitidis is a major cause of bacterial septicemia and meningitis. Sequence variation of surface-exposed proteins and cross-reactivity of the serogroup B capsular polysaccharide with human tissues have hampered efforts to develop a successful vaccine. To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. A total of 350 candidate antigens were expressed in Escherichia coli, purified, and used to immunize mice. The sera allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizza, M -- Scarlato, V -- Masignani, V -- Giuliani, M M -- Arico, B -- Comanducci, M -- Jennings, G T -- Baldi, L -- Bartolini, E -- Capecchi, B -- Galeotti, C L -- Luzzi, E -- Manetti, R -- Marchetti, E -- Mora, M -- Nuti, S -- Ratti, G -- Santini, L -- Savino, S -- Scarselli, M -- Storni, E -- Zuo, P -- Broeker, M -- Hundt, E -- Knapp, B -- Blair, E -- Mason, T -- Tettelin, H -- Hood, D W -- Jeffries, A C -- Saunders, N J -- Granoff, D M -- Venter, J C -- Moxon, E R -- Grandi, G -- Rappuoli, R -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1816-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10710308" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Bacterial/biosynthesis/blood ; Antigens, Bacterial/chemistry/genetics/*immunology ; Antigens, Surface/chemistry/genetics/immunology ; Bacterial Capsules ; Bacterial Proteins/chemistry/genetics/*immunology ; *Bacterial Vaccines/genetics/immunology ; Conserved Sequence ; Escherichia coli/genetics ; *Genome, Bacterial ; Humans ; Immune Sera/immunology ; Mice ; Neisseria meningitidis/classification/*genetics/*immunology/pathogenicity ; Open Reading Frames ; Recombinant Fusion Proteins/chemistry/immunology/isolation & purification ; Recombination, Genetic ; Sequence Analysis, DNA ; Serotyping ; Vaccination ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Helicobacter pylori virulence and genetic geography (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Covacci, A -- Telford, J L -- Del Giudice, G -- Parsonnet, J -- Rappuoli, R -- New York, N.Y. -- Science. 1999 May 21;284(5418):1328-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334982" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Bacterial Vaccines ; Biological Evolution ; Child ; Genetic Variation ; Helicobacter Infections/epidemiology/*microbiology/prevention & ; control/transmission ; Helicobacter pylori/*genetics/immunology/*pathogenicity ; Humans ; Peptic Ulcer/microbiology ; Stomach/*microbiology ; Stomach Neoplasms/microbiology ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Italy must invest more in science and technology (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertini, Ivano -- Garattini, Silvio -- Rappuoli, Rino -- England -- Nature. 2008 Apr 10;452(7188):685. doi: 10.1038/452685b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18401382" target="_blank"〉PubMed〈/a〉
    Keywords: Investments/*trends ; Italy ; Politics ; Science/*economics/trends ; Technology/*economics/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Public health. Rethinking influenza (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rappuoli, Rino -- Del Giudice, Giuseppe -- Nabel, Gary J -- Osterhaus, Albert D M E -- Robinson, Robin -- Salisbury, David -- Stohr, Klaus -- Treanor, John J -- New York, N.Y. -- Science. 2009 Oct 2;326(5949):50. doi: 10.1126/science.1179475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Novartis Vaccines and Diagnostics Srl, 53100 Siena, Italy. rino.rappuoli@novartis.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19797644" target="_blank"〉PubMed〈/a〉
    Keywords: Adjuvants, Immunologic ; Animals ; Antiviral Agents/therapeutic use ; Developed Countries ; Developing Countries ; *Disease Outbreaks/prevention & control ; Humans ; *Influenza A Virus, H1N1 Subtype/immunology ; *Influenza Vaccines/adverse effects/immunology ; *Influenza, Human/epidemiology/prevention & control/virology ; Mass Vaccination ; *Orthomyxoviridae/immunology ; Population Surveillance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Phylogeny of the SARS coronavirus (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eickmann, Markus -- Becker, Stephan -- Klenk, Hans-Dieter -- Doerr, Hans Wilhelm -- Stadler, Konrad -- Censini, Stefano -- Guidotti, Silvia -- Masignani, Vega -- Scarselli, Maria -- Mora, Marirosa -- Donati, Claudio -- Han, Jang H -- Song, Hyun Chul -- Abrignani, Sergio -- Covacci, Antonello -- Rappuoli, Rino -- New York, N.Y. -- Science. 2003 Nov 28;302(5650):1504-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14645828" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Sequence ; Consensus Sequence ; Coronavirus/chemistry/*classification ; Genome, Viral ; Membrane Glycoproteins/chemistry ; Nucleocapsid/chemistry ; *Phylogeny ; SARS Virus/chemistry/*classification/*genetics ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins/chemistry ; Viral Matrix Proteins/chemistry ; Viral Proteins/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Identification of a universal Group B streptococcus vaccine by multiple genome screen (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: Group B Streptococcus (GBS) is a multiserotype bacterial pathogen representing a major cause of life-threatening infections in newborns. To develop a broadly protective vaccine, we analyzed the genome sequences of eight GBS isolates and cloned and tested 312 surface proteins as vaccines. Four proteins elicited protection in mice, and their combination proved highly protective against a large panel of strains, including all circulating serotypes. Protection also correlated with antigen accessibility on the bacterial surface and with the induction of opsonophagocytic antibodies. Multigenome analysis and screening described here represent a powerful strategy for identifying potential vaccine candidates against highly variable pathogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351092/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351092/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maione, Domenico -- Margarit, Immaculada -- Rinaudo, Cira D -- Masignani, Vega -- Mora, Marirosa -- Scarselli, Maria -- Tettelin, Herve -- Brettoni, Cecilia -- Iacobini, Emilia T -- Rosini, Roberto -- D'Agostino, Nunzio -- Miorin, Lisa -- Buccato, Scilla -- Mariani, Massimo -- Galli, Giuliano -- Nogarotto, Renzo -- Nardi-Dei, Vincenzo -- Vegni, Filipo -- Fraser, Claire -- Mancuso, Giuseppe -- Teti, Giuseppe -- Madoff, Lawrence C -- Paoletti, Lawrence C -- Rappuoli, Rino -- Kasper, Dennis L -- Telford, John L -- Grandi, Guido -- AI-060603/AI/NIAID NIH HHS/ -- U01 AI060603/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):148-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chiron srl, Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Antibodies, Bacterial/biosynthesis ; Antigens, Bacterial/genetics/*immunology ; Antigens, Surface/genetics/immunology ; Bacterial Proteins/immunology ; Computational Biology ; Female ; *Genome, Bacterial ; Humans ; Immunity, Maternally-Acquired ; Mice ; Neutrophils/immunology ; Opsonin Proteins ; Phagocytosis ; Serotyping ; Streptococcal Infections/immunology/microbiology/*prevention & control ; Streptococcal Vaccines/*immunology ; Streptococcus agalactiae/classification/*genetics/*immunology ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Genome analysis reveals pili in Group B Streptococcus (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: Pili are essential virulence factors in many Gram-negative bacteria; however, they have not been described in most important Gram-positive pathogens. While screening the sequence of multiple genomes of Group B Streptococcus, we identified protective antigens that formed high molecular weight polymers. Immunogold electron microscopy revealed that the structures have a pilus-like form. These large structures have gone unrecognized in decades of studies of Group B Streptococcus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lauer, Peter -- Rinaudo, Cira D -- Soriani, Marco -- Margarit, Immaculada -- Maione, Domenico -- Rosini, Roberto -- Taddei, Anna Rita -- Mora, Marirosa -- Rappuoli, Rino -- Grandi, Guido -- Telford, John L -- U01-AI060693-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):105.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Bacterial/analysis/genetics/immunology ; Antigens, Surface/*analysis/genetics/immunology ; Fimbriae, Bacterial/immunology/physiology/*ultrastructure ; *Genome, Bacterial ; Immunohistochemistry ; Mice ; Microscopy, Immunoelectron ; Operon ; Streptococcal Infections/immunology ; Streptococcus agalactiae/*genetics/immunology/pathogenicity/*ultrastructure ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Medicine. The intangible value of vaccination (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rappuoli, Rino -- Miller, Henry I -- Falkow, Stanley -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):937-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy. rino_rappuoli@chiron.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169712" target="_blank"〉PubMed〈/a〉
    Keywords: Cost of Illness ; Cost-Benefit Analysis ; Developing Countries ; Drug Costs ; Drug Industry/economics ; Economics, Pharmaceutical ; Europe ; *Health ; Health Services/economics ; Humans ; Immunization Programs ; International Cooperation ; Marketing of Health Services ; Patents as Topic ; Policy Making ; Public Sector ; Taxes ; United States ; *Vaccination/economics ; *Vaccines/economics/supply & distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Reverse vaccinology and genomics (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-10-25
    Description: The genomic revolution has had a dramatic effect on our ability to find new vaccine targets and develop effective vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rappuoli, Rino -- Covacci, Antonello -- New York, N.Y. -- Science. 2003 Oct 24;302(5645):602.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron Vaccines, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14576423" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Bacterial Vaccines ; Bioterrorism ; Computational Biology ; Databases, Genetic ; *Genome ; Genome, Bacterial ; Genome, Viral ; *Genomics ; Humans ; Malaria Vaccines ; *Vaccines ; Vaccines, Synthetic ; Viral Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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