Publikationsdatum:
2007-04-28
Beschreibung:
MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610435/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610435/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodriguez, Antony -- Vigorito, Elena -- Clare, Simon -- Warren, Madhuri V -- Couttet, Philippe -- Soond, Dalya R -- van Dongen, Stijn -- Grocock, Russell J -- Das, Partha P -- Miska, Eric A -- Vetrie, David -- Okkenhaug, Klaus -- Enright, Anton J -- Dougan, Gordon -- Turner, Martin -- Bradley, Allan -- 077187/Wellcome Trust/United Kingdom -- G117/424/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Apr 27;316(5824):608-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17463290" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
3' Untranslated Regions
;
Animals
;
B-Lymphocytes/*immunology
;
Cytokines/biosynthesis
;
Dendritic Cells/*immunology
;
Gene Expression Regulation
;
Gene Targeting
;
Homeostasis
;
Immune System/*physiology
;
Immunoglobulin G/biosynthesis
;
Lung/pathology
;
Lung Diseases/immunology/pathology
;
Lymphocyte Activation
;
Mice
;
MicroRNAs/genetics/*physiology
;
Oligonucleotide Array Sequence Analysis
;
Proto-Oncogene Proteins c-maf/genetics/physiology
;
Salmonella Infections, Animal/immunology
;
T-Lymphocytes/*immunology
;
Th1 Cells/immunology
;
Th2 Cells/immunology
;
Vaccination
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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