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  • 1
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    Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-22
    Description: The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffiths, E K -- Krawczyk, C -- Kong, Y Y -- Raab, M -- Hyduk, S J -- Bouchard, D -- Chan, V S -- Kozieradzki, I -- Oliveira-Dos-Santos, A J -- Wakeham, A -- Ohashi, P S -- Cybulsky, M I -- Rudd, C E -- Penninger, J M -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2260-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567140" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; *Adaptor Proteins, Signal Transducing ; Animals ; Antigens, CD/metabolism ; Antigens, CD3/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; B-Lymphocytes/immunology ; Carrier Proteins/genetics/*physiology ; Cell Adhesion ; Cell Adhesion Molecules/metabolism ; Chimera ; Gene Targeting ; Humans ; Immunization ; Immunoglobulin G/biosynthesis ; Integrins/*metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Interferon-gamma/biosynthesis ; Interleukin-2/biosynthesis/pharmacology ; Lectins, C-Type ; *Lymphocyte Activation ; Lymphocyte Function-Associated Antigen-1/metabolism ; Mice ; Phosphoproteins/genetics/*physiology ; Receptors, Antigen, T-Cell/immunology/metabolism ; Receptors, Interleukin-2/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction ; T-Lymphocytes/immunology/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uchida, J -- Yasui, T -- Takaoka-Shichijo, Y -- Muraoka, M -- Kulwichit, W -- Raab-Traub, N -- Kikutani, H -- CA19014/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10514374" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Affinity ; Antigens, CD40/genetics/*metabolism ; B-Lymphocytes/*immunology/metabolism/virology ; Cell Differentiation ; Female ; Germinal Center/immunology/metabolism ; Herpesvirus 4, Human/*metabolism/physiology ; Immunization ; Immunoglobulin Class Switching ; Immunoglobulins/biosynthesis ; Interleukin-4/pharmacology ; *Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; *Molecular Mimicry ; NF-kappa B/metabolism ; Signal Transduction ; Spleen/immunology ; Viral Matrix Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    The Evolution of Striae in the Dust Tail of Comet Hale-Bopp - I. Wide-Field Imaging, Computer Processing, and Astrometry (1999)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: We report extensive observations of striation patterns in the dust tail of comet Hale-Bopp (C/1995 O1) over a period of more than 10 weeks, from mid-february until early May 1997.
    Keywords: Astrophysics
    Type: Astronomy and Astrophysics
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    NASA TECHNICAL REPORTS
  • 4
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    Progress in a Study of Striations in the Dust Tail of Comet Hale-Bopp (C/1995 O1) (1999)
    In:  Other Sources
    Details
    Publication Date: 2019-07-17
    Description: We report preliminary results of a massive investigation of the striation patterns observed in the dust tail of comet Hale-Bopp in March and April 1997. Our findings are based on 16 wide-field photographs taken with Schmidt cameras on March 2-20, with six more, from March 31-April 8, still waiting for analysis. Altogether approximately 700 individual striae were examined on the 16 images, which were scanned and computer processed to enhance the morphology. About 5300 stria points, or some 7-8 points per stria per image on the average, were measured and their astrometric positions determined and subsequently converted to a Cartesian coordinate system, aligned with the comet's projected radius vector and centered on the nucleus. The evolution of the striated tail has been studied using the Sekanina-Farrell fragmentation hypothesis (AJ 85, 1538, 1980), previously applied to other comets. This two-step model is characterized by the time of release from the nucleus of a parent object (or objects) whose motion is assumed to have been subjected to a constant repulsive acceleration beta(sub p) (presumably due to solar radiation pressure) until the time of fragmentation.
    Keywords: Astrophysics
    Format: text
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    NASA TECHNICAL REPORTS
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