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  • Antiparasitic agents  (1)
  • Cytotoxicity  (1)
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Years
  • 1
    Publication Date: 2021-05-19
    Description: A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7- ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.
    Description: Published
    Description: Marine sponge, Niphates digitalis, nucleosides, nucleobases, antimalarial activity, cytotoxicity
    Keywords: Cytotoxicity ; Sponges ; Sponges ; Cytotoxicity
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 2
    Publication Date: 2021-05-19
    Description: Marine sponges (Porifera) have drawn the attention from a broad number of researchers all over the world. These animals and their simbionts are specialized in chemical warfare, producing biologically active chemical substances as an effective defense against predators. They have been considered a goldmine to chemists, from which have been discovered more than 6000 novel structures; many of them, with enormous biomedical applications, mainly against cancer, but also against bacteria, viruses and other diseases. Some of the sponge-derived drugs are available in the market, such as: Ara-A (antiviral) and Ara-C (anticancer), but there are diverse bioactive compounds under clinical trials. In Cuba, the researches related to the isolation of compounds from marine sponges are scarce and the initial studies were about pharmacological evaluations of extracts and fractions. In recent studies, three sponges were investigated (Agelas cerebrum, Niphates digitalis and Pandaros acanthifolium), from which were isolated and identified 45 metabolites, two of them were isolated for the first time as natural products, including the discovery of 30 novel metabolites, dividing in two new families of steroidal saponins with uncommon chemical characteristics and potential against several parasitic protozoa and tumor human cell lines.
    Description: Published
    Description: marine sponges, novel compounds, bioactive metabolites, antiparasitic, antitumoral
    Keywords: Sponges ; Organic compounds ; Antiparasitic agents
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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