Publication Date:
1993-08-13
Description:
The zeta subunit of the T cell antigen receptor complex is required for targeting nascent receptor complexes to the cell surface and for receptor-mediated signal transduction. To examine the significance of the zeta subunit in T cell development, mice deficient for zeta expression were generated by gene targeting. These zeta-/- mice had few CD4+CD8+ thymocytes, and the generation of CD4+ and CD8+ single positive T cells was impaired but not completely abrogated. Peripheral T cells were present but were unusual in that they expressed small amounts of CD5 and few T cell receptors. Thus, zeta chain expression influences thymocyte differentiation but is not absolutely required for the generation of single positive T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Love, P E -- Shores, E W -- Johnson, M D -- Tremblay, M L -- Lee, E J -- Grinberg, A -- Huang, S P -- Singer, A -- Westphal, H -- New York, N.Y. -- Science. 1993 Aug 13;261(5123):918-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7688481" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/analysis
;
Antigens, CD3/analysis
;
Antigens, CD4/analysis
;
Antigens, CD5
;
Antigens, CD8/analysis
;
Cell Differentiation
;
Membrane Proteins/genetics/*physiology
;
Mice
;
Mutation
;
RNA, Messenger/genetics/metabolism
;
Receptors, Antigen, T-Cell/genetics/*physiology
;
Receptors, Antigen, T-Cell, alpha-beta/analysis
;
T-Lymphocyte Subsets/*cytology/immunology
;
Thymus Gland/cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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