ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Neurodegeneration: a question of balance (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, Leslie Michels -- England -- Nature. 2008 Apr 10;452(7188):707-8. doi: 10.1038/452707a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18401401" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxin-1 ; Ataxins ; Humans ; Mice ; Multiprotein Complexes/chemistry/metabolism ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Nuclear Proteins/chemistry/genetics/*metabolism ; Peptides/genetics/*metabolism ; Protein Binding ; Protein Structure, Quaternary ; Repressor Proteins/metabolism ; Spinocerebellar Ataxias/genetics/*metabolism/pathology ; *Trinucleotide Repeat Expansion/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    SUMO modification of Huntingtin and Huntington's disease pathology (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-06
    Description: Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein, Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a pathogenic fragment of Htt (Httex1p) can be modified either by small ubiquitin-like modifier (SUMO)-1 or by ubiquitin on identical lysine residues. In cultured cells, SUMOylation stabilizes Httex1p, reduces its ability to form aggregates, and promotes its capacity to repress transcription. In a Drosophila model of HD, SUMOylation of Httex1p exacerbates neurodegeneration, whereas ubiquitination of Httex1p abrogates neurodegeneration. Lysine mutations that prevent both SUMOylation and ubiquitination of Httex1p reduce HD pathology, indicating that the contribution of SUMOylation to HD pathology extends beyond preventing Htt ubiquitination and degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steffan, Joan S -- Agrawal, Namita -- Pallos, Judit -- Rockabrand, Erica -- Trotman, Lloyd C -- Slepko, Natalia -- Illes, Katalin -- Lukacsovich, Tamas -- Zhu, Ya-Zhen -- Cattaneo, Elena -- Pandolfi, Pier Paolo -- Thompson, Leslie Michels -- Marsh, J Lawrence -- CA-62203/CA/NCI NIH HHS/ -- HD36049/HD/NICHD NIH HHS/ -- HD36081/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):100-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, CA 92697, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15064418" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Cell Line ; Cell Nucleus/metabolism ; Corpus Striatum/cytology ; Cytoplasm/metabolism ; Drosophila ; Genes, MDR ; HeLa Cells ; Humans ; Huntington Disease/metabolism/*pathology ; Lysine/genetics/metabolism ; Mutation ; Nerve Degeneration ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Neurons/metabolism ; Nuclear Proteins/chemistry/genetics/*metabolism ; Proline/genetics/metabolism ; Promoter Regions, Genetic ; Rats ; Recombinant Fusion Proteins/metabolism ; SUMO-1 Protein/genetics/*metabolism ; Transcription, Genetic ; Transfection ; Ubiquitin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Cementation and Aqueous Alteration of a Sandstone Unit Under Acidic Conditions in Gale Crater, Mars (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Curiosity rover landed on Mars in August 2012 to explore the sedimentary history and to assess the habitability of Gale Crater. After 1200 sols of surface operations and over 12 km of traverse distance, the mineralogy of 10 samples has been determined by the CheMin X-ray diffractometer (XRD) and the chemical composition of nearly 300 targets has been established by the Alpha Particle X-ray Spectrometer (APXS). Light-toned fracture zones containing elevated concentrations of silica have been studied by Curiosity's instruments to determine the nature of the fluids that resulted in the enrichment of SiO2. Multiple fluid exposures are evident, and the chemistry and mineralogy data indicate at least two aqueous episodes may have occurred under acidic conditions.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-CN-35221 , Lunar and Planetary Science Conference; Mar 21, 2016 - Mar 25, 2016; The Woodlands, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 4
    facet.materialart.
    Unknown
    Evolved Gas Analyses of the Murray Formation in Gale Crater, Mars: Results of the Curiosity Rover's Sample Analysis at Mars (SAM) Instrument (2017)
    In:  CASI
    Details
    Publication Date: 2019-07-12
    Description: The Sample Analysis at Mars (SAM) instrument aboard the Mars Science Laboratory rover has analyzed 13 samples from Gale Crater. All SAM-evolved gas analyses have yielded a multitude of volatiles (e.g., H2O, SO2, H2S, CO2, CO, NO, O2, HCl) [1- 6]. The objectives of this work are to 1) Characterize recent evolved SO2, CO2, O2, and NO gas traces of the Murray formation mudstone, 2) Constrain sediment mineralogy/composition based on SAM evolved gas analysis (SAM-EGA), and 3) Discuss the implications of these results relative to understanding the geological history of Gale Crater.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-CN-38722
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 5
    facet.materialart.
    Unknown
    Compositional Characteristics and Trends Within the Vera Rubin Ridge, Gale Crater, Mars as Determined by APXS: Sedimentary, Diagenetic and Alteration History (2019)
    In:  CASI
    Details
    Publication Date: 2019-07-20
    Description: The Mars Science Laboratory (MSL) Curiosity rover has spent the last two years investigating a prominent resistant ridge, informally named the Vera Rubin Ridge (VRR), at the base of Mount Sharp (Aeolis Mons). The ridge has been a high priority science target for the MSL mission since landing in Gale crater more than 6 years ago because of the detection of a strong hematite spectral signature, and its distinct topography. Examining the chemistry of the ridge can aid in determining the relationship to other rocks analyzed during the rover traverse, specifically the Murray formation (fm) encountered below the ridge. We can also determine compositional trends with elevation and/or laterally within the ridge, and whether spectral properties observed on the ridge, both from orbit and in situ, correspond with changes in chemistry. The composition of the ridge, combined with mineralogy of drilled samples, can help to elucidate bigger picture questions regarding depositional environment, possible changing lake water chemistry and diagenetic/alteration history.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-E-DAA-TN66081 , Lunar and Planetary Science Conference (LPSC); Mar 18, 2019 - Mar 22, 2019; Woodlands, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    Origin and Speciation of Sulfur Compounds in the Murray Formation, Gale Crater, Mars (2019)
    In:  CASI
    Details
    Publication Date: 2019-07-20
    Description: The Mars Curiosity rover has traversed nearly 20 km and gained over 350 meters in elevation since landing in Gale crater in August 2012. Through 2250 sols of surface operations, Curiosity has spent approximately 60% of its time investigating the Murray formation, a unit of layered sediments. The occurrence of sulfur compounds in the Murray formation has been established by imaging of light-toned veins by MastCam and MAHLI, chemical compositions measured by the Alpha Particle X-ray Spectrometer (APXS) and ChemCam, crystalline phase identifications by the CheMin X-ray diffractometer, and evolved gas analyses from the Sample Analysis at Mars (SAM) instrument.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-E-DAA-TN64832 , Lunar and Planetary Science Conference; Mar 18, 2019 - Mar 22, 2019; Woodlands, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 7
    facet.materialart.
    Unknown
    Evolved Gas Analyses of Sedimentary Rocks and Eolian Sediment in Gale Crater, Mars: Results of the Curiosity Rover's Sample Analysis at Mars Instrument from Yellowknife Bay to the Namib Dune (2017)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The sample analysis at Mars instrument evolved gas analyzer (SAM-EGA) has detected evolved water, H2, SO2, H2S, NO, CO2, CO, O2, and HCl from two eolian sediments and nine sedimentary rocks from Gale Crater, Mars. These evolved gas detections indicate nitrates, organics, oxychlorine phase, and sulfates are widespread with phyllosilicates and carbonates occurring in select Gale Crater materials. Coevolved CO2 (160 +/- 248-2373 +/- 820 gC(CO2)/g) and CO (11 +/- 3-320 +/- 130 gC(CO)/g) suggest that organic C is present in Gale Crater materials. Five samples evolved CO2 at temperatures consistent with carbonate (0.32 +/- 0.05-0.70 +/- 0.1 wt % CO3). Evolved NO amounts to 0.002 +/- 0.007-0.06 +/- 0.03 wt % NO3. Evolution of O2 suggests that oxychlorine phases (chlorate/perchlorate) (0.05 +/- 0.025-1.05 +/- 0.44 wt % ClO4) are present, while SO2 evolution indicates the presence of crystalline and/or poorly crystalline Fe and Mg sulfate and possibly sulfide. Evolved H2O (0.9 +/- 0.3-2.5 +/- 1.6 wt % H2O) is consistent with the presence of adsorbed water, hydrated salts, interlayer/structural water from phyllosilicates, and possible inclusion water in mineral/amorphous phases. Evolved H2 and H2S suggest that reduced phases occur despite the presence of oxidized phases (nitrate, oxychlorine, sulfate, and carbonate). SAM results coupled with CheMin mineralogical and Alpha-Particle X-ray Spectrometer elemental analyses indicate that Gale Crater sedimentary rocks have experienced a complex authigenetic/diagenetic history involving fluids with varying pH, redox, and salt composition. The inferred geochemical conditions were favorable for microbial habitability and if life ever existed, there was likely sufficient organic C to support a small microbial population.
    Keywords: Lunar and Planetary Science and Exploration
    Type: GSFC-E-DAA-TN54011 , Journal of Geophysical Research: Planets (ISSN 2169-9097) (e-ISSN 2169-9100); 122; 12; 2574-2609
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 8
    facet.materialart.
    Unknown
    Curiosity's Investigation at Vera Rubin Ridge (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Curiosity rover is exploring Vera Rubin Ridge (VRR), a ~6.5 km long and ~200 m wide topographic feature trending northeast-southwest across Aeolis Mons (informally known as Mt. Sharp) (Fig 1). In orbital data, VRR is distinct from the underlying Murray formation due to its relative erosional resistance and greater exposure of bedrock. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) orbital data show a hematite spectral signature over much of the ridge (Fig. 2). On the ground, Curiosity also observed hematite associated with the sedimentary rocks of the underlying Murray formation, although these detections are difficult to see with CRISM due to mixing with sand and dust.
    Keywords: Lunar and Planetary Science and Exploration
    Type: LPI Contrib. No. 2083-1557 , JSC-E-DAA-TN53589 , Lunar and Planetary Science Conference (LPSC); Mar 19, 2018 - Mar 23, 2018; Woodlands, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 9
    facet.materialart.
    Unknown
    Understanding Martian Alteration Processes by Comparing In-Situ Chemical Measurements from Multiple Landing Sites (2019)
    In:  CASI
    Details
    Publication Date: 2019-07-30
    Description: Characterizing the history of aqueous activity at the martian surface has been an objective of the Mars Exploration Rovers (MER) and the Mars Science Laboratory (MSL). Although the geologic context of the three landing sites are different, comparisons across the datasets can provide greater insight than using data from one mission alone. The Alpha Particle X-ray Spectrometer (APXS) is common to all three rovers (Spirit at Gusev crater, Opportunity at Meridiani Planum, and Curiosity at Gale crater) and provides a consistent basis for these comparisons. Soil and Dust: Fine grained basaltic soils and dust are remarkably uniform in chemical composition across multiple landing sites. These similarities in the concentrations of major, minor, and a few trace elements (Fig. 1) are indicative of planet-wide consistency in the composition of source materials for the soils. S and Cl vary by a factor of two in the soil and dust, but there is no clear association with any bulk cation (e.g., no correlation between S and total Ca, Mg, or Fe in soils). These volatile elements, however, are clearly associated with the nanophase-ferric iron component in the soil established by Mssbauer spectroscopy [1,2]. S and Cl likely originated as acidic species from volcanic out-gassing and subsequently coalesced on dust and sand grain surfaces, possibly with an affinity towards Fe3+ sites. Importantly, given the mobility of S and Cl in aqueous exposures, soil samples maintaining the typical molar S/Cl ratio of ~3.7:1 indicate minimal interactions with liquid water after the addition of S and Cl. In contrast to this well-established baseline, soil samples have been discovered at all three landing sites with atypical S/Cl ratios (e.g., subsurface soils), indicative of a more complex aqueous history.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-E-DAA-TN70395 , International Conference on Mars; Jul 22, 2019 - Jul 25, 2019; Pasadena, CA; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 10
    facet.materialart.
    Unknown
    Sulfur on Mars (2019)
    In:  CASI
    Details
    Publication Date: 2019-08-06
    Description: The S contents of rocks and soils are indicative of various alteration processes on Mars, e.g.[1]. It has been quantified along traverses at 4 landing sites Pathfinder, both MERs and MSL by the APXS [2,3]. At the MSL and MER sites, sulfur abundances, correlations with likely bound cations and other elements, and complementary mineralogical and textural data have provided important insights into alteration processes and periods of more habitable environments in the distant past.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-E-DAA-TN70393 , International Conference on Mars; Jul 22, 2019 - Jul 25, 2019; Pasadena, CA; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...