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  • 1
    Electronic Resource
    Electronic Resource
    Interphase mass and heat transfer in pulsatile flow (1975)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 21 (1975), S. 743-752 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A study on the effects of flow pulsations on interphase mass or heat transfer has been made. The situation corresponds to fully developed flow in a long conduit with a periodic pressure gradient at amplitudes which cause flow pulsations without flow reversal. It is shown that the basic three-parameter formulation can be reduced to a one-parameter problem in the boundary layer formulation. Solutions are developed over wide ranges of the parameters in both the basic and the boundary layer formulations.The boundary approach gives accurate results over wide ranges of the parameters. Pulsations cause increases in the time-averaged interphase flux at intermediate values of a composite frequency-space variable. However, at small values of this variable the pulsations cause a decrease in the flux such that the overall space-averaged flux is always decreased.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690210415
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  • 2
    Electronic Resource
    Electronic Resource
    C60H4: Kinetik und Thermodynamik der mehrfachen Addition an C60 Diese Arbeit wurde vom US Department of Energy (Laboratory Directed Research and Development Program, DE-AC04-94AL85000) gefördert. (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 106 (1994), S. 803-805 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19941060720
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  • 3
    Electronic Resource
    Electronic Resource
    Importance of enolate anions in the high-pressure kinetics of nitroalkanes and nitroaromatics (1986)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 18 (1986), S. 1205-1214 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We review and systematize experimental evidence concerning the extreme high-pressure kinetics of condensed phase nitroalkanes and nitroaromatics. This systematization suggests that enolate aci anions of the nitroalkanes and enolate aci-quinone anions of the nitroaromatics are important in the initial high-pressure kinetics of such systems. Kinetic data from experiments which observed the effect of: (1) small amounts of chemical additives, (2) substitution for protons, (3) difference in chemical isomer, (4) exposure to ultra-violet light, and (5) application of very high pressure can all be rationalized within the framework of our hypothesis. We suggest a static high-pressure ultra-violet absorption spectroscopy experiment on nitromethane that would test the proposed hypothesis.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550181009
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  • 4
    Electronic Resource
    Electronic Resource
    C60H4: Kinetics and Thermodynamics of Multiple Addition to C60This work was supported at Sandia National Laboratories under the Laboratory Directed Research and Development Program by the US Department of Energy under contract DE-AC04-94AL85000. (1994)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 33 (1994), S. 786-788 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199407861
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  • 5
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    HIV/AIDS. HLA leaves its footprints on HIV (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMichael, Andrew -- Klenerman, Paul -- New York, N.Y. -- Science. 2002 May 24;296(5572):1410-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK. andrew.mcmichael@clinical-medicine.oxford.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029119" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Epitopes/genetics/immunology ; Epitopes, T-Lymphocyte/genetics/immunology ; Gene Products, pol/immunology ; Genes, MHC Class I ; HIV Antigens/genetics/*immunology ; HIV Core Protein p24/genetics/immunology ; HIV Infections/*immunology/virology ; HIV-1/genetics/*immunology/physiology ; HLA Antigens/genetics/*immunology ; HLA-B Antigens/immunology ; HLA-B27 Antigen/immunology ; Histocompatibility Antigens Class I/genetics/*immunology ; Humans ; Immunodominant Epitopes/genetics/immunology ; Macaca ; Mutation ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Immunodeficiency Virus/genetics/immunology ; T-Lymphocytes, Cytotoxic/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    AIDS/HIV. Finding footprints among the trees (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klenerman, Paul -- McMichael, Andrew -- MC_U137884177/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Mar 16;315(5818):1505-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nuffield Department of Clinical Medicine, Peter Medawar Building, University of Oxford, Oxford OX1 3SY, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17363650" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines ; Alleles ; Animals ; Antigen Presentation ; Epitopes/genetics/immunology ; Evolution, Molecular ; Founder Effect ; Genes, MHC Class I ; Genes, Viral ; HIV Antigens/genetics/immunology ; HIV Infections/immunology/*virology ; HIV-1/classification/*genetics/*immunology ; HLA Antigens/*genetics/immunology ; Hepacivirus/genetics/immunology ; Humans ; Immune Tolerance ; *Mutation ; Phylogeny ; T-Lymphocytes/*immunology ; Viral Hepatitis Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Rio+20: Don't forget health in sustainability talks (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brijnath, Bianca -- McMichael, Anthony J -- Butler, Colin D -- England -- Nature. 2012 Jun 13;486(7402):191. doi: 10.1038/486191a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22699600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brazil ; *Conservation of Natural Resources ; *Global Health ; Humans
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    A critical role for conserved residues in the cleft of HLA-A2 in presentation of a nonapeptide to T cells (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-08-14
    Description: The peptide binding cleft of the class I human histocompatibility antigen, HLA-A2, contains conserved amino acid residues clustered in the two ends of the cleft in pockets A and F as well as polymorphic residues. The function of two conserved tyrosines in the A pocket was investigated by mutating them to phenylalanines and of a conserved tyrosine and threonine in the F pocket by mutating them to phenylalanine and valine, respectively. Presentation of influenza virus peptides and of intact virus to cytolytic T lymphocytes (CTLs) was then examined. The magnitude of the reduction seen by the mutation of the two tyrosines in the A pocket suggests that hydrogen bonds involving them have a critical function in the binding of the NH2-terminal NH3+ of the peptide nonamer and possibly of all bound peptide nonamers. In contrast, the mutations in the F pocket had no effect on CTL recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Latron, F -- Pazmany, L -- Morrison, J -- Moots, R -- Saper, M A -- McMichael, A -- Strominger, J L -- AI 20182/AI/NIAID NIH HHS/ -- CA 47554/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1992 Aug 14;257(5072):964-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1380181" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; B-Lymphocytes/immunology ; Binding Sites ; Cell Line ; Cloning, Molecular ; Epitopes/immunology/metabolism ; HLA-A2 Antigen/chemistry/genetics/*metabolism ; Influenza A virus ; Kinetics ; Models, Molecular ; Mutagenesis, Site-Directed ; Oligopeptides/immunology/*metabolism ; Protein Conformation ; Recombinant Proteins/chemistry/metabolism ; T-Lymphocytes, Cytotoxic/*immunology ; Transfection ; Viral Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    A specific inhibitor of the epidermal growth factor receptor tyrosine kinase (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-08-19
    Description: A small molecule called PD 153035 inhibited the epidermal growth factor (EGF) receptor tyrosine kinase with a 5-pM inhibition constant. The inhibitor was specific for the EGF receptor tyrosine kinase and inhibited other purified tyrosine kinases only at micromolar or higher concentrations. PD 153035 rapidly suppressed autophosphorylation of the EGF receptor at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells and selectively blocked EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. PD 153035 demonstrates an increase in potency over that of other tyrosine kinase inhibitors of four to five orders of magnitude for inhibition of isolated EGF receptor tyrosine kinase and three to four orders of magnitude for inhibition of cellular phosphorylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fry, D W -- Kraker, A J -- McMichael, A -- Ambroso, L A -- Nelson, J M -- Leopold, W R -- Connors, R W -- Bridges, A J -- New York, N.Y. -- Science. 1994 Aug 19;265(5175):1093-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8066447" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Cell Transformation, Neoplastic/drug effects ; Epidermal Growth Factor/pharmacology ; Fibroblast Growth Factor 2/pharmacology ; Gene Expression/drug effects ; Humans ; Kinetics ; Mice ; Mitosis/drug effects ; Phosphorylation/drug effects ; Platelet-Derived Growth Factor/pharmacology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Quinazolines/*antagonists & inhibitors ; Receptor, Epidermal Growth Factor/*antagonists & inhibitors ; Tumor Cells, Cultured ; Tyrosine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Immunology. Antigen processing takes a new direction (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goonetilleke, Nilu -- McMichael, Andrew J -- New York, N.Y. -- Science. 2013 May 24;340(6135):937-8. doi: 10.1126/science.1239649.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704564" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD8-Positive T-Lymphocytes/*immunology ; Cytomegalovirus/*immunology ; Epitopes, T-Lymphocyte/*immunology ; Female ; Genetic Vectors/*immunology ; Humans ; Male ; SAIDS Vaccines/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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