ISSN:
1432-1211
Keywords:
Key words Complement C5
;
Anaphylatoxin C5a
;
C5a receptor
;
G protein-coupled receptor
;
Gene polymorphism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence of 2.8%) and among patients with end-stage renal failure who had previously undergone renal graft (prevalence 1.4%, not significantly different from that of the control group). This new marker provides a valuable tool to assess the risk for putative C5a-associated disorders with genetic determinism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002510050657
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