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Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor

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Abstract

 A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence of 2.8%) and among patients with end-stage renal failure who had previously undergone renal graft (prevalence 1.4%, not significantly different from that of the control group). This new marker provides a valuable tool to assess the risk for putative C5a-associated disorders with genetic determinism.

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Authors and Affiliations

  1. Centre Hospitalier Universitaire de Québec, Centre de recherche du Pavillon l'Hôtel-Dieu de Québec, 11 Côte-du-Palais, Québec (Québec) G1R 2J6, Canada e-mail: dimchob@rsvs.ulaval.ca Tel.: +1-418-6915590, Fax: +1-418-6915562, , , , , , CA

    François Marceau, Magdalena Bachvarova, Jean Bergeron & D. R. Bachvarov

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  1. François Marceau
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  2. Magdalena Bachvarova
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  3. Jean Bergeron
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  4. D. R. Bachvarov
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Received: 20 November 1998 / Revised: 24 February 1999

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Marceau, F., Bachvarova, M., Bergeron, J. et al. Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor. Immunogenetics 49, 618–619 (1999). https://doi.org/10.1007/s002510050657

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  • DOI: https://doi.org/10.1007/s002510050657

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