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  • 1
    Publication Date: 2008-11-15
    Description: Climate models incorporate photosynthesis-climate feedbacks, yet we lack robust tools for large-scale assessments of these processes. Recent work suggests that carbonyl sulfide (COS), a trace gas consumed by plants, could provide a valuable constraint on photosynthesis. Here we analyze airborne observations of COS and carbon dioxide concentrations during the growing season over North America with a three-dimensional atmospheric transport model. We successfully modeled the persistent vertical drawdown of atmospheric COS using the quantitative relation between COS and photosynthesis that has been measured in plant chamber experiments. Furthermore, this drawdown is driven by plant uptake rather than other continental and oceanic fluxes in the model. These results provide quantitative evidence that COS gradients in the continental growing season may have broad use as a measurement-based photosynthesis tracer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, J E -- Carmichael, G R -- Chai, T -- Mena-Carrasco, M -- Tang, Y -- Blake, D R -- Blake, N J -- Vay, S A -- Collatz, G J -- Baker, I -- Berry, J A -- Montzka, S A -- Sweeney, C -- Schnoor, J L -- Stanier, C O -- New York, N.Y. -- Science. 2008 Nov 14;322(5904):1085-8. doi: 10.1126/science.1164015.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA 52242, USA. ecampbell3@ucmerced.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19008442" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/*chemistry ; Carbon Dioxide/analysis/metabolism ; North America ; *Photosynthesis ; Plant Development ; Plants/*metabolism ; Seasons ; Sulfur Oxides/*analysis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 173-178 
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A study of the effect of crystal size on the bioavailability of benoxaprofen, 2-[4-chlorophenyl]-α-methyl-5-benzoxazoleacetic acid, in man is reported. The technique utilized comparison of either the plasma concentrations or urine levels, resulting from administration of deuterium labeled (2H7) drug in solution coadministered with a test capsule formulation. Drug concentrations were determined by gas chromatography, and the ratio of labeled to unlabeled drug was obtained by gas chromatography mass spectrometry. Measurements following coadministration of labeled and unlabeled drug in solution established the absence of an isotope effect due to the presence of deuterium. The dry formulations consisted of either a 3.17-100 micron fraction (mean = 18.5 microns) or a 32-1000 micron fraction (mean = 610 microns) formulated with starch powder. The results in three subjects indicate an almost complete availability (0.95-0.98) of the small crystals as measured by comparison of either area under the plasma level curves or urine excretion (0.94-0.97) of labeled versus unlabeled drug measured to 168 hours. The larger crystals exhibited a lower availability as shown by plasma levels (0.41-0.46) or urine recovery (0.39-0.43). A higher dose of the large crystal formulation resulted in decreased relative availability with a fourfold dose dropping availability to 0.22 in a single subject.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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