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  • Biochemistry and Biotechnology  (4)
  • Drug utilization  (4)
  • Epidemiological methods  (2)
  • Analgesics  (1)
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  • 1
    ISSN: 1573-739X
    Keywords: Acitretin ; Data collection ; Dermatologists ; Drug utilization ; Epidemiological methods ; Pharmacists ; Product surveillance, postmarketing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In October 1990, a recall procedure was issued regarding the drug acitretin. The recommended post-therapy contraception period after acitretin therapy was extended from 2 months to 2 years. For a postmarketing surveillance study, we recruited a cohort from the source population of women aged 15–45 years who were exposed to acitretin. Recruitment occurred through dermatologists, and pharmacists plus dispensing general practitioners. We describe the speed of and the response to the recruitment procedures, and the representativeness of the recruited cohort. We also studied whether the individuals who gave informed consent would have preferred to be recruited by either dermatologists or pharmacists, and whether the information obtained from pharmacists and dispensing general practitioners was valid. This study revealed that pharmacists and dispensing general practitioners (drug dispensers) recruited their subjects rapidly, with no or little selection; they attained a 42% response. Dermatologists recruited their subjects slowly and selectively; they attained a 24% response. The majority of women (60%) recruited by dermatologists would have given their informed consent if they would have been recruited by their pharmacists. Drug dispensers are essential contributors to the recruitment of a study population. We do advise that such recruitment for a postmarketing surveillance study occurs by means of a collaboration between pharmacists and physicians.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 13 (1991), S. 32-38 
    ISSN: 1573-739X
    Keywords: Drug utilization ; Epidemiological methods ; Lactation ; Pregnancy ; Prenatal care
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In this study the use of prescribed drugs before, during and after pregnancy is described. The study is based on data obtained from pharmacy records of 1,948 women who delivered a live-born infant. Different measures to evaluate drug exposure are used. During the nine months of pregnancy 86% of the women used on average 4.2 prescriptions. During the course of pregnancy the use of gastro-intestinal and blood-forming drugs increased, whereas the use of cardiovascular, antiphlogistic and central nervous system drugs decreased. Anti-emetics were predominantly used in the first trimester, and antacids in the last trimester, whereas laxatives were especially used after delivery. The percentage of women who used a treatment for vaginal infections increased from 2 to 7 during pregnancy. Most of the women (73%) received one or more iron prescriptions during the course of pregnancy, however, the prescribed daily dose was low (prescribed daily dose/defined daily dose=0.6). At least 1% of the women filled a new prescription for anticonceptives in the first trimester of pregnancy. Most likely, our data reflect the general prescribing pattern for Dutch pregnant women who delivered a live-born baby. Therefore, they form a good and detailed base for further studies, for instance, on the exposure to drugs with known or suspected risks or on the use of drugs in patients with chronic concomitant diseases. Such studies may lead to recommendations that may improve prescribing behaviour.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 14 (1992), S. 38-45 
    ISSN: 1573-739X
    Keywords: Analgesics ; Antibiotics ; Anticonvulsants ; Cardiovascular agents ; Drug utilization ; Pregnancy ; Prescriptions, drug ; Psychotropic drugs ; Teratogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The drug use of nearly 2,000 pregnant women was evaluated at the level of the individual patient for the drugs belonging to the Australian risk categories B3, C and D. The pattern of changes in the use of these drugs is studied in terms of women who discontinue (d), continue (c) or begin (b) using the drug during pregnancy. The ratios d/(c+b) and d/b were the highest for the drugs belonging to the high-risk groups and the lowest for drugs from the low-risk categories. This suggests a congruence between theoretical knowledge and daily practice. Patients who had already been using a drug for a long time before pregnancy, more frequently continued using that drug than patients who had been using the drug only incidentally before. The described daily dose for the riskful drugs was approximately 20% lower in patients who started to use a drug during pregnancy compared to those who continued drug use. The data from this analysis indicate that the prescribing physician is generally aware of the possible risks of drug use during pregnancy. The d/(b+c) and d/b ratios are shown to be a good measure of prescribing behaviour in relation to pregnancy and can be used to compare knowledge of theory and daily practice.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 15 (1993), S. 73-78 
    ISSN: 1573-739X
    Keywords: Antibiotics ; Anti-inflammatory agents ; Curaçao ; Drug utilization ; Netherlands Antilles ; Psychotropic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The drug use on Curaçao was evaluated with the help of the prescription forms of twelve community pharmacies at Curaçao over a period of three months. The emphasis of the study was on three therapeutic groups: the systemic antibiotics, the psycholeptics and the anti-inflammatory and antirheumatic drugs. Within the group of systemic antibiotics broad-spectrum antibiotics were very frequently prescribed compared with the small-spectrum penicillins. The consumption of psycholeptics, particularly benzodiazepines, on Curaçao is remarkably low in comparison with drug utilization data of Denmark and the Netherlands. In contrast, the number of defined daily doses per 1,000 persons per day of antirheumatic drugs is higher compared with data from these two countries. Within the analysed groups, large differences occur between the two most important kinds of insurance,i.c., the poor people (PP) and social insurance bank (SVB) insurance. The PP-insured patients consume in the case of antibiotics and antirheumatic drugs almost twice as many and in the case of psycholeptics even five times as many as the SVB-insured patients do. A few calculations of prices prove that the extra amount of drugs consumed by PP-insured has important financial consequences.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 800-806 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new hybrid reactor, the upflow blanket filter (UBF), which combined on open volume in the bottom two-thirds of the reactor for a sludge blanket and submerged plastic rings (Flexiring, Koch Inc., 235 m2/m3) in the upper one-third of the reactor volume, was studied. This UBF reactor was operated at 27°C at loading rates varying from 5 to 51 g chemical oxygen demand (COD)/L d with soluble sugar wastewater (2500 mg COD/L). Maximum removal rates of 34 g COD/L d and CH4 production rates of 7 vol/vol d [standard temperature and pressure (STP)] were obtained. The biomass activity was about 1.2 g COD/g volatile suspended solids per day. Conversion (based on effluent soluble COD) was over 93% with loading rates up to 26 g COD/L d. At higher loading rates conversion decreased rapidly. The packing was very efficient in retaining biomass.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 392-393 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 10-19 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Tests to determine the mixing characteristics of the anaerobic downflow stationary fixed film (DSFF) reactor during startup showed that mixing characteristics affected performance. Different mixing profiles were obtained by keeping the same flow distribution system and by varying the number of clay channels (1, 4, and 25) in the DSFF reactors (2-32 L). Results with a clean bed reactor indicated a plug flow pattern with a relatively large extent of dispersion. Recirculation dramatically improved the mixing and the residence time distribution (RTD) changed to that of the completely mixed type. Multiple-channel reactors exhibited a dead space of ca. 12% of the total volume, likely a result of a less than optimally designed flow distributor. A startup period of 90 days was necessary to achieve a maximum loading rate of between 10 and 15 kg COD/m3 day, a volumetric methane production rate of up to 3 m3 (STP)/m3 day and a COD reduction efficiency of up to 90%. For the first 50 days of operation, the difference in achievable volumetric loading rate and volumetric methane production rate was only related to the surface-to-volume ratio of the reactors and was not affected by the number of channels present. After 90 days, the bacterial growth on the support material was sufficient to dramatically increase the amount of dead space in the reactors, especially in multiple-channel reactors (up to 55% of their volume). As a result, the performance of these reactors deteriorated and overloading characteristics were observed. Other results showed that biogas production alone was not sufficient to improve reactor mixing and that little or no shortcircuiting or channelling occurred. Furthermore, the nonmethanogenic bacterial activity in the liquid phase was not affected by the degree of mixing but acetoclastic methanogenic and hydrogenophilic methanogenic activity in the liquid phase were reduced as the fluid flow pattern in the reactor improved.
    Additional Material: 11 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 16 (1974), S. 1459-1469 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An apparatus is described for the rapid measurement and recording of methanogenic activity in anaerobic fermentations, and its application is demonstrated in the evaluation of the anaerobic contact process, using pear waste. The method is based on recording the rate of manometer liquid displacement in a Warburgtype vessel by means of optical sensors, appropriate electronic circuitry, and an event marking recorder or time-interval printer. Optimum conditions for measuring methanogenic activity included a pH of 6.7-6.9, a final phosphate buffer concentration of 0.07-015M, and formic and acetic acid contents of over 500 and 200 mg/liter, respectively. In comparisons of fermenter liquid and settled effluent, methanogenic activity can be assumed to be proportional to the number of methane formers present. The apparatus should be generally useful in recording rates of gas production or consumption.
    Additional Material: 5 Ill.
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