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  • 1
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    Specifying and sustaining pigmentation patterns in domestic and wild cats (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-22
    Description: Color markings among felid species display both a remarkable diversity and a common underlying periodicity. A similar range of patterns in domestic cats suggests a conserved mechanism whose appearance can be altered by selection. We identified the gene responsible for tabby pattern variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-bound metalloprotease. Analyzing 31 other felid species, we identified Taqpep as the cause of the rare king cheetah phenotype, in which spots coalesce into blotches and stripes. Histologic, genomic expression, and transgenic mouse studies indicate that paracrine expression of Endothelin3 (Edn3) coordinates localized color differences. We propose a two-stage model in which Taqpep helps to establish a periodic pre-pattern during skin development that is later implemented by differential expression of Edn3.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709578/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709578/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaelin, Christopher B -- Xu, Xiao -- Hong, Lewis Z -- David, Victor A -- McGowan, Kelly A -- Schmidt-Kuntzel, Anne -- Roelke, Melody E -- Pino, Javier -- Pontius, Joan -- Cooper, Gregory M -- Manuel, Hermogenes -- Swanson, William F -- Marker, Laurie -- Harper, Cindy K -- van Dyk, Ann -- Yue, Bisong -- Mullikin, James C -- Warren, Wesley C -- Eizirik, Eduardo -- Kos, Lidia -- O'Brien, Stephen J -- Barsh, Gregory S -- Menotti-Raymond, Marilyn -- N01-CO-12400/CO/NCI NIH HHS/ -- U54 HG003079/HG/NHGRI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1536-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22997338" target="_blank"〉PubMed〈/a〉
    Keywords: Acinonyx/genetics/metabolism ; Alleles ; Aminopeptidases/chemistry/*genetics/metabolism ; Animals ; Cats/embryology/*genetics/growth & development/metabolism ; Endothelin-3/*genetics/metabolism ; Epistasis, Genetic ; Felidae/*genetics/growth & development/metabolism ; Gene Expression Regulation ; Gene Frequency ; Genetic Variation ; Hair/embryology/growth & development ; Hair Color/*genetics ; Hair Follicle/embryology ; Haplotypes ; Metalloproteases/chemistry/*genetics/metabolism ; Mice ; Mice, Transgenic ; Panthera/genetics/metabolism ; Phenotype ; Polymorphism, Single Nucleotide ; Skin/anatomy & histology/embryology/*metabolism ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-07
    Description: GSK1265744 (GSK744) is an integrase strand-transfer inhibitor that has been formulated as a long-acting (LA) injectable suitable for monthly to quarterly clinical administration. GSK744 LA was administered at two time points 4 weeks apart beginning 1 week before virus administration, and macaques were challenged weekly for 8 weeks. GSK744 LA, at plasma concentrations achievable with quarterly injections in humans, protected all animals against repeated low-dose challenges. In a second experiment, macaques were given GSK744 LA 1 week before virus administration and challenged repeatedly until infection occurred. Protection decreased over time and correlated with the plasma drug levels. With a quarterly dosing schedule in humans, our results suggest that GSK744 LA could potentially decrease adherence problems associated with daily preexposure prophylaxis (PrEP).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308974/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308974/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews, Chasity D -- Spreen, William R -- Mohri, Hiroshi -- Moss, Lee -- Ford, Susan -- Gettie, Agegnehu -- Russell-Lodrigue, Kasi -- Bohm, Rudolf P -- Cheng-Mayer, Cecilia -- Hong, Zhi -- Markowitz, Martin -- Ho, David D -- 1DP1-DA033263/DA/NIDA NIH HHS/ -- 2P51-OD11104-52/OD/NIH HHS/ -- P51 OD011104/OD/NIH HHS/ -- R0-AI100724/AI/NIAID NIH HHS/ -- R01 AI100724/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1151-4. doi: 10.1126/science.1248707. Epub 2014 Mar 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24594934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Delayed-Action Preparations/administration & dosage/pharmacokinetics ; HIV Infections/*prevention & control ; HIV Integrase Inhibitors/*administration & dosage/blood/pharmacokinetics ; HIV-1/*drug effects ; Humans ; Macaca mulatta ; Molecular Sequence Data ; Pyridones/*administration & dosage ; Rectum/virology ; Simian Acquired Immunodeficiency Syndrome/*prevention & control ; Simian Immunodeficiency Virus/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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