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  • 1
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    A family of AMPA-selective glutamate receptors (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-03
    Description: Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keinanen, K -- Wisden, W -- Sommer, B -- Werner, P -- Herb, A -- Verdoorn, T A -- Sakmann, B -- Seeburg, P H -- New York, N.Y. -- Science. 1990 Aug 3;249(4968):556-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Neuroendocrinology, University of Heidelberg, F.R.G.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2166337" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Brain/*metabolism/physiology ; Glutamates/metabolism/pharmacology ; Ibotenic Acid/analogs & derivatives/*pharmacology ; Kainic Acid/pharmacology ; Kinetics ; Molecular Sequence Data ; *Multigene Family ; Oligonucleotide Probes ; Organ Specificity ; Oxadiazoles/pharmacology ; Oxazoles/*pharmacology ; Quisqualic Acid ; RNA, Messenger/analysis/genetics ; Rats ; Receptors, Glutamate ; Receptors, Neurotransmitter/drug effects/*genetics/physiology ; Sequence Homology, Nucleic Acid ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-09-28
    Description: In the central nervous system (CNS), the principal mediators of fast synaptic excitatory neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). In each member of a family of four abundant AMPA receptors, a small segment preceding the predicted fourth transmembrane region has been shown to exist in two versions with different amino acid sequences. These modules, designated "flip" and "flop," are encoded by adjacent exons of the receptor genes and impart different pharmacological and kinetic properties on currents evoked by L-glutamate or AMPA, but not those evoked by kainate. For each receptor, the alternatively spliced messenger RNAs show distinct expression patterns in rat brain, particularly in the CA1 and CA3 fields of the hippocampus. These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sommer, B -- Keinanen, K -- Verdoorn, T A -- Wisden, W -- Burnashev, N -- Herb, A -- Kohler, M -- Takagi, T -- Sakmann, B -- Seeburg, P H -- New York, N.Y. -- Science. 1990 Sep 28;249(4976):1580-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F.R.G.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1699275" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Brain/*metabolism ; DNA/genetics ; Exons ; Genomic Library ; Glutamates/*metabolism/pharmacology ; Ibotenic Acid/*analogs & derivatives/metabolism/pharmacology ; Ion Channels/*physiology ; Kinetics ; Molecular Sequence Data ; Oligonucleotide Probes ; Organ Specificity ; *RNA Splicing ; RNA, Messenger/*genetics ; Rats ; Receptors, AMPA ; Receptors, Glutamate ; Receptors, Neurotransmitter/drug effects/*genetics/physiology ; Recombinant Proteins/metabolism ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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