ISSN:
1434-193X
Keywords:
Dynamic combinatorial chemistry
;
Molecular recognition
;
Hydrogen bonding
;
Hydrazone isomerization
;
Barbiturate receptor
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The selection of the receptor presenting the strongest affinity for a barbiturate substrate from a dynamic combinatorial library of constituents differing in structure and conformation/configuration is described. The gradual addition of the barbiturate to an equilibrating mixture of hydrazone isomers leads to the quantitative shift towards a single species, 3, which presents highest complementarity to the substrate and yields the supramolecular entity 3:4.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
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