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  • 1
    Publication Date: 1983-10-07
    Description: Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M C -- Nuttall, A L -- Masta, R I -- NS-05785/NS/NINDS NIH HHS/ -- NS-07106/NS/NINDS NIH HHS/ -- NS-15107/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):69-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623058" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Cochlea/*physiology ; Electric Stimulation ; Guinea Pigs ; Hair Cells, Auditory/*physiology ; Hair Cells, Auditory, Inner/*physiology ; Hearing/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 408-418 
    ISSN: 1741-0444
    Keywords: Activity ; Metrifonate ; Oxamniquine ; Schistosome ; Ultrasonics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Il décrit une méthode de mise au point et d'application in vitro, de l'effet de médicaments antischistosome sur l'activité des schistosomes. Le système décrit enregistre l'activité de troubles causés par les mouvements des vers, dans un champ ultrasonore de 10 MHz. Les enregistrements de l'activité, allant jusqu'à 10 canaus, sont relevés par ordinateur, et les changements d'activité sont évalués au moyen de statistique. On démontre et étudie les changement d'activité, dus aux réactions des Métrifonate et Oxamniquine.
    Abstract: Zusammenfassung Eine Methode zur Feststellung der Wirkung schistosomalhemmender Medikamente auf die Tätigkeit der Schistosomen in vitro wurde erarbeitet und ausgewertet. Die Methode erläutert Tätigkeitsaufzeichnungen, der durch die Wurmbewegungen erzeugten Unregelmäßigkeiten in einem 10 MHz Ultraschallfeld. Tätigkeitsaufzeichnungen von bis zu 10 Kanälen werden von einem Computer aufgezeichnet und die Tätigkeitsveränderungen werden zufriedenstellend ausgewertet. Es werden die Tätigkeitsveränderungen in bezug auf Metrifonate und Oxamniquine dargestellt und diskutiert.
    Notes: Abstract A method of assessing the effect of antischistosomal drugs on the activity of schistosomes,in vitro has been devised and exploited. The system described records activity from the disturbances caused by the worm movements in a 10 MHz ultrasonic field. Activity recordings from up to 10 channels are plotted by computer, and changes in activity evaluated statistically. The activity changes in response to Metrifonate and to Oxamniquine are demonstrated and discussed
    Type of Medium: Electronic Resource
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