ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    AIDS in a new millennium (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-06
    Description: As we enter the new millennium the world is still facing the challenge of responding to the AIDS pandemic. A new report from the Joint United Nations Programme on HIV/AIDS presents the latest statistics on prevalence, spread, and impact of the disease. In their Perspective, Schwartlander and his colleagues discuss the newly released statistics and the strategies needed to combat the further spread of HIV/AIDS and to reduce prevalence in the most severely affected countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartlander, B -- Garnett, G -- Walker, N -- Anderson, R -- New York, N.Y. -- Science. 2000 Jul 7;289(5476):64-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UNAIDS, 20 Avenue Appia, Geneva 27 CH-1211, Switzerland. schwartlanderb@unaids.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10928930" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/drug therapy/*epidemiology/prevention & ; control/transmission ; Anti-HIV Agents/therapeutic use ; *Disease Outbreaks ; Female ; *Global Health ; HIV Infections/drug therapy/*epidemiology/prevention & control/transmission ; Health Policy ; Humans ; Infectious Disease Transmission, Vertical ; Male ; Population Dynamics ; Prevalence ; Risk-Taking ; Sexual Behavior ; United Nations
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-05-23
    Description: The effects of selection by host immune responses on transmission dynamics was analyzed in a broad class of antigenically diverse pathogens. Strong selection can cause pathogen populations to stably segregate into discrete strains with nonoverlapping antigenic repertoires. However, over a wide range of intermediate levels of selection, strain structure is unstable, varying in a manner that is either cyclical or chaotic. These results have implications for the interpretation of longitudinal epidemiological data on strain or serotype abundance, design of surveillance strategies, and the assessment of multivalent vaccine trials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, S -- Ferguson, N -- Anderson, R -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 May 8;280(5365):912-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for the Epidemiology of Infectious Disease, Zoology Department, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. sunetra.gupta@zoology.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9572737" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Antibody Formation ; *Antigenic Variation ; Antigens, Bacterial/immunology ; Antigens, Protozoan/immunology ; Antigens, Viral/immunology ; Bacteria/classification/genetics/*immunology/pathogenicity ; Cross Reactions ; Eukaryota/classification/genetics/*immunology/pathogenicity ; Humans ; Immunity ; Infection/epidemiology/*immunology/microbiology/parasitology/transmission ; Mathematics ; Models, Biological ; Nonlinear Dynamics ; Serotyping ; Viruses/classification/genetics/*immunology/pathogenicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-17
    Description: Exocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis of toxoplasmosis and malaria. DOC2 proteins recruit the membrane fusion machinery required for exocytosis in a Ca(2+)-dependent fashion. Here, the phenotype of a Toxoplasma gondii conditional mutant impaired in host cell invasion and egress was pinpointed to a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion proteins. Whole-genome sequencing identified the etiological point mutation in TgDOC2.1. A conditional allele of the orthologous gene engineered into Plasmodium falciparum was also defective in microneme secretion. However, the major effect was on invasion, suggesting that microneme secretion is dispensable for Plasmodium egress.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354045/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354045/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farrell, Andrew -- Thirugnanam, Sivasakthivel -- Lorestani, Alexander -- Dvorin, Jeffrey D -- Eidell, Keith P -- Ferguson, David J P -- Anderson-White, Brooke R -- Duraisingh, Manoj T -- Marth, Gabor T -- Gubbels, Marc-Jan -- AI057919/AI/NIAID NIH HHS/ -- AI081220/AI/NIAID NIH HHS/ -- AI087874/AI/NIAID NIH HHS/ -- AI088314/AI/NIAID NIH HHS/ -- HG004719/HG/NHGRI NIH HHS/ -- K08 AI087874/AI/NIAID NIH HHS/ -- K08 AI087874-02/AI/NIAID NIH HHS/ -- R01 AI057919/AI/NIAID NIH HHS/ -- R01 HG004719/HG/NHGRI NIH HHS/ -- R21 AI081220/AI/NIAID NIH HHS/ -- R21 AI088314/AI/NIAID NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 13;335(6065):218-21. doi: 10.1126/science.1210829.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22246776" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Calcium/*metabolism ; Calcium-Binding Proteins/chemistry/genetics/*metabolism ; Cell Line ; *Exocytosis ; Genes, Protozoan ; Genetic Complementation Test ; Genome, Protozoan ; Humans ; Models, Molecular ; Molecular Sequence Data ; Movement ; Mutagenesis ; Organelles/*metabolism ; Plasmodium falciparum/genetics/growth & development/physiology ; Point Mutation ; Protein Structure, Tertiary ; Protozoan Proteins/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Toxoplasma/genetics/growth & development/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-10
    Description: The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose approximately 37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of the selection is unknown. The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain. It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, Patrick D -- Gilbert, Sandra L -- Mekel-Bobrov, Nitzan -- Vallender, Eric J -- Anderson, Jeffrey R -- Vaez-Azizi, Leila M -- Tishkoff, Sarah A -- Hudson, Richard R -- Lahn, Bruce T -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1717-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151009" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; African Continental Ancestry Group/genetics ; Alleles ; Amino Acid Substitution ; Asian Continental Ancestry Group/genetics ; *Biological Evolution ; Brain/*anatomy & histology/physiology ; European Continental Ancestry Group/genetics ; Exons ; Gene Conversion ; Gene Frequency ; Genetic Variation ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Microcephaly/genetics ; Nerve Tissue Proteins/*genetics ; Organ Size ; Polymorphism, Genetic ; Recombination, Genetic ; *Selection, Genetic ; Sequence Analysis, DNA ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Legionella effectors that promote nonlytic release from protozoa (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: Legionella pneumophila, the bacterial agent of legionnaires' disease, replicates intracellularly within a specialized vacuole of mammalian and protozoan host cells. Little is known about the specialized vacuole except that the Icm/Dot type IV secretion system is essential for its formation and maintenance. The Legionella genome database contains two open reading frames encoding polypeptides (LepA and LepB) with predicted coiled-coil regions and weak homology to SNAREs; these are delivered to host cells by an Icm/Dot-dependent mechanism. Analysis of mutant strains suggests that the Lep proteins may enable the Legionella to commandeer a protozoan exocytic pathway for dissemination of the pathogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, John -- de Felipe, Karim Suwwan -- Clarke, Margaret -- Lu, Hao -- Anderson, O Roger -- Segal, Gil -- Shuman, Howard A -- NIH-R01 AI23549/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1358-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988561" target="_blank"〉PubMed〈/a〉
    Keywords: Acanthamoeba/*microbiology/physiology/ultrastructure ; Animals ; Bacterial Proteins/genetics/metabolism/*physiology ; Cell Line ; Colony Count, Microbial ; Cyclic AMP/metabolism ; Dictyostelium/*microbiology/physiology/ultrastructure ; Exocytosis ; Genome, Bacterial ; Humans ; Legionella pneumophila/*genetics/growth & development/pathogenicity/*physiology ; Lysosomes/physiology ; Macrophages/microbiology/ultrastructure ; Mutation ; Open Reading Frames ; Phagosomes/physiology ; Recombinant Fusion Proteins/metabolism ; Vacuoles/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-10
    Description: The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mekel-Bobrov, Nitzan -- Gilbert, Sandra L -- Evans, Patrick D -- Vallender, Eric J -- Anderson, Jeffrey R -- Hudson, Richard R -- Tishkoff, Sarah A -- Lahn, Bruce T -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1720-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151010" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; African Continental Ancestry Group ; Animals ; Asian Continental Ancestry Group/genetics ; *Biological Evolution ; Brain/*anatomy & histology/physiology ; European Continental Ancestry Group ; Gene Conversion ; Gene Frequency ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Models, Genetic ; Nerve Tissue Proteins/*genetics ; Organ Size ; Pan troglodytes/genetics ; Phylogeny ; Polymorphism, Genetic ; Recombination, Genetic ; *Selection, Genetic ; Sequence Analysis, DNA ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Personalized medicine: Keep a way open for tailored treatments (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-04-21
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375895/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375895/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leek, Jeffrey T -- Peng, Roger D -- Anderson, R Reeves -- R01 ES019560/ES/NIEHS NIH HHS/ -- England -- Nature. 2012 Apr 18;484(7394):318. doi: 10.1038/484318a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517151" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Humans ; *Information Dissemination ; Institute of Medicine (U.S.) ; Patents as Topic/*legislation & jurisprudence ; Precision Medicine/*economics/*trends ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Lyme disease study (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, D R -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1103.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502024" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Protocols ; Humans ; *Lyme Disease ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Photosynthesis of previtamin D3 in human skin and the physiologic consequences (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-10
    Description: Photosynthesis of previtamin D3 can occur throughout the epidermis in the dermis when hypopigmented Caucasian skin is exposed to solar ultraviolet radiation. Once previtamin D3 is formed in the skin, it undergoes a temperature-dependent thermal isomerization that takes at least 3 days to complete. The vitamin D-binding protein preferentially translocates the thermal product, vitamin D3, into the circulation. These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D3 from the skin into the circulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holick, M F -- MacLaughlin, J A -- Clark, M B -- Holick, S A -- Potts, J T Jr -- Anderson, R R -- Blank, I H -- Parrish, J A -- Elias, P -- AM25395-01/AM/NIADDK NIH HHS/ -- AM27334-01/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):203-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/metabolism ; Cholecalciferol/*biosynthesis ; Cholestadienols/*biosynthesis ; Dose-Response Relationship, Radiation ; Hot Temperature ; Humans ; Isomerism ; Photochemistry ; Rats ; Skin/cytology/*metabolism ; Ultraviolet Rays ; Vitamin D/metabolism ; Vitamin D-Binding Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-28
    Description: The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLaughlin, J A -- Anderson, R R -- Holick, M F -- AM 27334/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1001-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281884" target="_blank"〉PubMed〈/a〉
    Keywords: Cholecalciferol/*biosynthesis/metabolism ; Dehydrocholesterols/radiation effects ; Ergosterol/metabolism ; Humans ; In Vitro Techniques ; Isomerism ; Photochemistry ; Skin/*metabolism ; Spectrum Analysis ; Structure-Activity Relationship ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...