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  • SPACE RADIATION  (19)
  • ASTROPHYSICS  (6)
  • Biochemistry, Neuroscience  (1)
  • 1
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    Near-atomic model of microtubule-tau interactions (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-06-15
    Description: Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer’s disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo–electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau-tubulin interactions. The conserved tubulin-binding repeats within tau adopt similar extended structures along the crest of the protofilament, stabilizing the interface between tubulin dimers. Our structures explain the effect of phosphorylation on MT affinity and lead to a model of tau repeats binding in tandem along protofilaments, tethering together tubulin dimers and stabilizing polymerization interfaces.
    Keywords: Biochemistry, Neuroscience
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Primeval gas clouds and the low-energy X-ray background (1977)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: A model for the appearance of the all-sky low-energy X-ray background on a fine angular scale is presented which is based on primeval hot gas clouds associated with the formation of clusters of galaxies according to the Sunyaev-Zel'dovich (1972) model. It is noted that the background could have both granular and diffuse components if it is due to such gas clouds. The observed appearance of the granular component is predicted along with the observable characteristics of collapsing protoclusters. The effects of distant X-ray-emitting QSOs, radio galaxies, and normal galaxies on the observations are considered, and these sources are shown not to interfere with the possibility of observing the protoclusters. It is concluded that if sufficient heating occurred in an intracluster medium within some clusters of galaxies at the protocluster epoch, the ensemble properties of protoclusters could be observed with an X-ray telescope, and the time at which protoclusters formed could perhaps be estimated.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; vol. 218
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    X-ray astronomy in the Uhuru epoch and beyond /Newton Lacy Pierce Prize Lecture/ (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: A review of results from the Uhuru satellite is presented. An intensive treatment of two subjects is given, rather than a broad review. First, Cyg X-1, a stellar X-ray source and a candidate for a black hole, is discussed; second, the X-ray source in the Perseus cluster of galaxies, which may be a cloud of hot intergalactic gas, is treated. In both cases, the train of logic used in establishing the nature of these objects is presented and evaluated. For both, while alternative explanations cannot be completely eliminated, they become more difficult to sustain when examined in detail, suggesting that the candidate explanations are more likely correct.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 197; May 1
    Format: text
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  • 4
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    On the nature of the unidentified high latitude UHURU sources (1973)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: It is found that the unidentified high latitude UHURU sources can have either of two very different explanations. They must either reside at great distances with luminosity equivalent to or greater than 10 to the 46th power ergs/sec, or be contained in the galaxy with luminosity equivalent to or less than 10 to the 34th power ergs/sec. The two possibilities are indistinguishable with the available data.
    Keywords: SPACE RADIATION
    Type: NASA-TM-X-70541 , X-661-73-361
    Format: application/pdf
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  • 5
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    Thermal-bremsstrahlung interpretation of cluster X-ray sources. (1973)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Analysis of the X-ray data for the extended sources in Coma, Perseus, and Virgo in terms of an isothermal gas-sphere model emitting thermal-bremsstrahlung radiation. It is found that the gas distribution is somewhat less centrally condensed than the galaxies, and that the gas mass is generally a small fraction of the binding mass of each cluster. In the case of the Coma cluster, approximately one-eighth of the binding mass (with an uncertainty of about 50%) may be in the form of hot gas at 100,000,000 K if H sub zero = 50 km/sec/Mpc.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 184; Sept. 15
    Format: text
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  • 6
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    Further X-ray observations of Hercules X-1 from Uhuru. (1973)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Recent data are presented concerning the X-ray source Hercules X-1. Details of the 1.24-sec pulse shape and its variability are shown. The 1.24-sec period is observed to decrease with time, with an overall change of 4.5 microsec between January and July 1972. The X-ray intensity shows regular on states lasting 11 or 12 days followed by 24-day off states. While the source turn-on is not strictly periodic, the shape of the on state can be used to determine a period of 34.88 plus or minus 0.12 days for this cycle. The source turn-ons are found to only occur at one of two well-defined phases in the 1.7-day orbit.-
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 184; Aug. 15
    Format: text
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  • 7
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    Discovery of a periodic pulsating binary X-ray source in Hercules from Uhuru. (1972)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: We have discovered a new pulsating X-ray source with a 1.24-sec period in the constellation Hercules. Analysis of 5 months of data has shown the existence of periodic variations in the intensity of the source and correlated sinusoidal variations in the period of the 1.24-sec pulsations. As in the case of the pulsating X-ray source Cen X-3, we interpret this effect as due to an occulting binary system, with the intensity changes due to occultation of the X-ray source by its companion and with the sinusoidal variations in the period of the 1.24-sec pulsations due to the Doppler effect. In addition, we have observed a longer-time scale cycle in which the source is bright and pulsing for approximately 9 days during which we can observe the 1.7-day occulting, followed by approximately 27 days during which the source is not detected above background on individual 20-sec scans.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 174; June 15
    Format: text
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  • 8
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    Further observations of the pulsating X-ray source Cygnus X-1 from Uhuru. (1971)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Since the discovery of the pulsations from the X-ray source Cygnus X-1 more data from Uhuru have been analyzed. The conclusions reached about the temporal behavior of the source are described. Large fluctuations of intensity exist on all observed time scales ranging from 50 msec to 10 sec containing up to 50 per cent of the power. Periodic pulse trains with periods from 0.3 sec to over 10 sec exist containing 10-25 per cent of the power; however, they persist only for several seconds or several tens of seconds. No single period is consistently present. This behavior is shown to reconcile the apparently contradictory results obtained by other observers. The energy spectrum of the source is best fitted by a power law, but with great variability in the spectral index and with an excess of flux at higher energies.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 170; Nov. 15
    Format: text
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  • 9
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    A high-sensitivity X-ray survey using the Einstein Observatory and the discrete source contribution to the extragalactic X-ray background (1979)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Surveys of two fields have been carried out utilizing the X-ray imaging instruments of the Einstein Observatory to a limiting flux of 1.3 x 10 to the -14th ergs/sq cm s in the 1-3 keV band, a several hundred-fold increase in sensitivity with respect to previous surveys. Forty-three objects are observed with positional accuracies varying from 5 to 60 arcsec. Optical and radio studies of candidate counterparts are described. The number-intensity relationship for extragalactic sources is evaluated, and the consequences of the findings are discussed with particular emphasis on the discrete source contribution to the extragalactic X-ray background. It is concluded that a large fraction of the background is due to previously unresolved discrete sources.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; vol. 234
    Format: text
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  • 10
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    Studies of cluster X-ray sources, energy spectra for the Perseus, Virgo, and Coma clusters (1975)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Final Uhuru X-ray differential-energy spectra are presented for the Perseus, Virgo, and Coma clusters. Power-law and isothermal bremsstrahlung model spectra with low-energy cutoffs are given, and the energy-dependent Gaunt factor is calculated for the bremsstrahlung. The spectra, which are best fits to the Uhuru data between 2 and 10 keV, are compared with previous observations of these sources in the energy range from 0.1 to 100 keV. The problem of parameter estimation is discussed, error bars with 68% confidence are given for the independently determined slope and cutoff parameters, and the 68% confidence limits are plotted for the fitted spectral functions. The data for Perseus above 20 keV marginally favor the bremsstrahlung fit, those for Virgo between 0.25 and 1.0 keV clearly favor that curve, and those for Coma indicate a low-energy turnover or cutoff. Implications of such a cutoff are briefly discussed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 199; July 15
    Format: text
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