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  • 1
    Electronic Resource
    Electronic Resource
    The Order of Exposure of Tau to Signal Transduction Kinases Alters the Generation of “AD-Like” Phosphoepitopes (1999)
    Springer
    Cellular and molecular neurobiology 19 (1999), S. 223-233 
    Details
    ISSN: 1573-6830
    Keywords: tau ; kinases ; signal transduction ; Alzheimer's disease ; phosphorylation ; paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The individual and sequential influence of protein kinase C (PKC), protein kinase A (PKA) and mitogen-activated protein kinase (MAP kinase) on human brain tau was examined. 2. A range of PKC concentrations generated certain phosphoepitopes common with paired helical filaments. These epitopes were masked by higher PKC concentrations, suggesting the presence of multiple tau phosphorylation sites for which PKC exhibited differing affinities and/or conformational alterations in tau induced by sequential PKC-mediated phosphorylation. 3. Prior phosphorylation by PKC enhanced the nature and extent of AD-like tau antigenicity generated by subsequent incubation with MAP kinase yet inhibited that generated by subsequent incubation with PKA. 4. Dephosphorylation of tau prior to incubation with kinases significantly altered the influence of individual and multiple kinase incubation on tau antigenicity in a site-specific manner, indicating that prior in situ phosphorylation events markedly influenced subsequent cell-free phosphorylation. 5. In addition to considerations of the potential impact of tau phosphorylation by individual kinases, these findings extend previous studies which indicate that tau antigenicity, and, presumably, its behavior in situ, is influenced by the sequential and convergent influences of multiple kinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006977127422
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperactivation of Mitogen-Activated Protein Kinase Increases Phospho-Tau Immunoreactivity Within Human Neuroblastoma: Additive and Synergistic Influence of Alteration of Additional Kinase Activities (1999)
    Springer
    Cellular and molecular neurobiology 19 (1999), S. 249-260 
    Details
    ISSN: 1573-6830
    Keywords: MAP kinase ; tau ; protein kinase C ; wortmannin ; PD98059 ; neuroblastoma ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mitogen-activated protein (MAP) kinase phosphorylates tau in cell-free analyses, but whether or not it does so within intact cells remains controversial. In the present study, microinjection of MAP kinase into SH-SY-5Y human neuroblastoma cells increased tau immunoreactivity toward the phosphodependent antibodies PHF-1 and AT-8. In contrast, treatment with a specific inhibitor of MAP kinase (PD98059) did not diminish “basal” levels of these immunoreactivities in otherwise untreated cells. These findings indicate that hyperactivation of MAP kinase increases phospho-tau levels within cells, despite that MAP kinase apparently does not substantially influence intracellular tau phosphorylation under normal conditions. These findings underscore that results obtained following inhibition of kinase activities do not necessarily provide an indication of the consequences accompanying hyperactivation of that same kinase. Several studies conducted in cell-free systems indicate that exposure of tau to multiple kinases can have synergistic effects on the nature and extent of tau phosphorylation. We therefore examined whether or not such effects could be demonstrated within these cells. Site-specific phospho-tau immunoreactivity was increased in additive and synergistic manners by treatment of injected cells with TPA (which activates PKC), calcium ionophore (which activates calcium-dependent kinases), and wortmannin (which inhibits PIP3 kinase). Alteration in total tau levels was insufficient to account for the full extent of the increase in phospho-tau immunoreactivity. These additional results indicate that multiple kinase activities modulate the influence of MAP kinase on tau within intact cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006981228331
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  • 3
    Electronic Resource
    Electronic Resource
    Phosphorylation of Tau Alters Its Association with the Plasma Membrane (2000)
    Springer
    Cellular and molecular neurobiology 20 (2000), S. 497-508 
    Details
    ISSN: 1573-6830
    Keywords: tau ; phosphorylation ; signal transduction ; protein kinase C ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The potential functions of the microtubule-associated protein tau have been expanded by the recent demonstration of its interaction with the plasma membrane. Since the association of tau with microtubules is regulated by phosphorylation, herein we examine whether or not the association of tau with the plasma membrane is also regulated by phosphorylation. 2. A range of tau isoforms migrating from 46 to 64 kDa was associated with crude particulate fractions derived from SH-SY-5Y human neuroblastoma cells, and were retained during the initial stages of plasma membrane purification. During the extensive washing utilized in purification of the plasma membrane, portions of each of these isoforms were depleted from the resultant purified membrane. Immunoblot analysis with phospho-dependent and -independent antibodies revealed selective depletion of phospho isoforms during membrane washing. This effect was more pronounced for the slowest-migrating (64-kDa) tau isoform. 3. This putative influence of phosphorylation on the association of tau with the plasma membrane was further probed by transfection of SH-SY-5Y human neuroblastoma cells with a tau construct that could associate with the plasma membrane but not with microtubules. Treatment with phorbol ester or calcium ionophore, both of which increased phospho-tau levels within the cytosol and plasma membrane, was accompanied by the dissociation of this tau construct from the membrane. 4. These data indicate that phosphorylation regulates the association with the plasma membrane. Dissociation from the membrane by phosphorylation may place tau at risk for hyperphosphorylation and ultimate PHF formation in a manner previously considered for tau dissociated from microtubules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007075115574
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  • 4
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    Radial and latitudinal gradients in the interplanetary magnetic field - Evidence for meridional flux transport (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Magnetic field data obtained by the Pioneer 10 and 11 spacecraft in the heliosphere from 1972-1982 and earth orbiting satellite data are examined in terms of radial and latitudinal gradients in the field components and magnitude. The data reveal that higher than expected gradients are observed in the magnetic field and time variations affect the field throughout the low-latitude heliosphere. It is determined that the high radial gradient is caused by meridional flux transport with low-latitude field lines moving to higher heliographic latitudes. High pressure near the solar equator and pressure due to heating in compressive solar wind interaction regions and the large field magnitudes that occur in these regions are investigated as mechanisms that produce the meridional flux. A solar cycle variation in the level of flux transport is analyzed.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 91; 6760-676
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  • 5
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    Theoretical interpretation of the observed interplanetary magnetic field radial variation in the outer solar system (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Observations of the azimuthal component of the IMF are evaluated through the use of an MHD model which shows the effect of magnetic flux tubes opening in the outer solar system. It is demonstrated that the inferred meridional transport of magnetic flux is consistent with predictions by the MHD model. The computed azimuthal and radial magnetic flux deficits are almost identical to the observations. It is suggested that the simplest interpretation of the observations is that meridional flows are created by a direct body force on the plasma. This is consistent with the analytic model of Nerney and Suess (1975), in which such flux deficits in the IMF arise naturally from the meridional gradient in the spiralling field.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 90; 4378-438
    Format: text
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  • 6
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    Asteroids: A source of natural resources for terrestrial and extra-terrestrial applications (1976)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Keywords: ASTROPHYSICS
    Type: Lunar Science Inst., Abstracts of Papers Presented at a Special Session of the Seventh Annual Lunar Science Conference on Utilization of Lunar Materials and Expertise for Large Scale Operations in Space; p 143-147
    Format: application/pdf
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  • 7
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    The Parker spiral configuration of the interplanetary magnetic field between 1 and 8.5 AU (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The magnetic field data from the Pioneer 10 and 11 spacecraft show that the field directions between 1 and 8.5 AU are in accordance with the Parker spiral directions within quiet and interaction regions. The included angle between the inward and outward sectored field directions is near 180 deg; the field direction manifests greater variability in quiet regions than in interaction zones. The fractional polarities below 10 deg heliographic latitude are dominated by temporal variations; however, dual-spacecraft investigations permitted a significant latitudinal gradient to be extracted. The sector structure extended occasionally to 16 deg heliographic latitude during the period of average current sheet inclination in 1976; it is proposed that the fast streams associated with interaction regions may move the current sheet to higher latitudes when the source of the fast plasma is in the southern solar hemisphere.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research; 85; Dec. 1
    Format: text
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  • 8
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    An interactive companion to the S star HD 35155 (1991)
    In:  Other Sources
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    Publication Date: 2019-07-12
    Description: Low-dispersion UV spectra taken by the IUE satellite of an S star HD 35155 are presented. It is shown that the spectra contain strong emission lines of multiply ionizes species and an excess continuous emission shortward of 2000 A. Because neither the photospheres nor chromospheres of S stars are expected to produce multiply ionized ions, the emission lines and the excess short-wave emission seen in the HD 35155 spectra are interpreted as an evidence of the presence of a hot nearby compact companion. Some inferences regarding the compact companion and the possible location of the source of the emission lines of multiply ionized ions are discussed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 383; 842-852
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  • 9
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    Geometry and pulse profiles of x-ray pulsars: Asymmetric relativistic fits to 4U1538 - 52 and vela x-1 (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-08-27
    Description: Model calculation of inhomogenuous magnetized neutron star atmospheres are used to analyze the phase-dependent spectra of 4U 1538-52 and Vela X-1 taking into account general relativistic effects. A chi (exp 2) fitting procedure is used on the Ginga data for these objects to determine the geometry and the magnetic structure of the polar caps, as well as their size and location on the surface of the stars. Other parameters determined by the fit are the masses and radii of neutron stars, the accretion rates, and the rotation and magnetic inclination angles including an azimuthal offset to reproduce the asymmetry of the pulse shapes. We find that general relativistic effects play a significant role in determining the derived cap sizes, the fluxes, and the observational appearance of the pulses. There is evidence that the polar caps are unequal and nonantipodal, suggesting either an off-center or bent magnetic axis, or a strong nondipole component. The magnetic field structure is approximated by a two-component model. The rotation axes are inferred to be moderately close to the mean magnetic axes and seen at large inclinations with respect to the line of sight.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 1; p. 405-414
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  • 10
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    Ultraviolet and optical studies of binaries with luminous cool primaries and hot companions. IV - Further IUE detections (1993)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: We have obtained IUE spectra for 31 middle and late-type giant and supergiant stars whose TD-1 fluxes or ground-based spectra indicate the presence of a hot component, or whose radial velocities indicate an unseen component. Stellar components earlier than type F1 were detected in 22 cases. While 20 of the hot secondaries are seen weakly in optical spectra, two are UV discoveries: HD 58134 and HD 183864. The hot companions are classified accurately by temperature class from their far-UV spectra. The interstellar extinction of each system and the relative luminosities of the components are derived from the UV and optical fluxes, using a new grid of UV intrinsic colors for hot dwarfs. We find that many giant stars apparently have companions which are too hot and hence too luminous for consistency with the primary's spectral classification.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 412; 2; p. 814-826.
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