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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 247-249 
    Details
    ISSN: 1432-1041
    Keywords: metaclazepam ; benzodiazepines ; (KC-2547) ; N-desmethyl-methaclazepam KC-3755) ; pharmacokinetics ; old and young volunteers ; side-effects ; age effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547431
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacodynamics and pharmacokinetics of urapidil in hypertensive patients: A crossover study comparing infusion with an infusion-capsule combination (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: urapidil ; hypertension ; alpha-adrenoceptor blocker ; antihypertensive agent ; pharmacodynamics ; pharmacokinetics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and haemodynamic effects of infused urapidil and an infusion-capsule combination were followed to study the correlation between the serum urapidil level and the blood pressure. Prior to urapidil administration, basal blood pressure and heart rate were measured for 16 h in 12 male hypertensive patients. Six patients received infusions lasting for 4 h of urapidil 10, 2.5 and 5 mg/h. Six patients were infused with urapidil 10 mg/h for 4 h and 2 h after the end of the infusion each took a 60-mg capsule. After a 5 day washout period the procedures were crossed over. A maximum serum urapidil level of 625±232 ng/ml was achieved at the end of the 10 mg/h infusion, when the fall in blood pressure was 37/21 mmHg. During the 2.5 and 5 mg/h infusions the serum urapidil level was 330 and 420 ng/ml, respectively, and the corresponding decreases in blood pressure were 28/16 mmHg and 31/8 mmHg. Although the urapidil concentration 1 hour after beginning the infusion was only 184±89 ng/ml a near maximal blood pressure decrease had already occurred 33±9/20±8 mmHg, whereas, 1 h after the end of the infusion the reduction in blood pressure was only 10±12/3±8 mm, with a urapidil concentration of 358±120 ng/ml. During the plateau phases of both the infusion and infusion-capsule treatments the falls in blood pressure followed the serum urapidil levels. Only in the initial rising and final falling phases of the treatments were the pharmacodynamics and pharmacokinetics of urapidil not correlated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609958
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  • 3
    Electronic Resource
    Electronic Resource
    Mathematical simulation of a biofilm process (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 921-931 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model has been developed for a fixed-film biological process (film flow over a flat plate) that describes bulk liquid transport, diffusional transport of oxygen and organics across a stagnant film, diffusional transport of oxygen and organics into the biofilm, biochemical reactions by the individual cells within the biofilm, biofilm growth, and cell density changes within the biofilm due to cellular decay. Simulation studies are presented to show how contact time and diffusion layer thickness affect process performance.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260270702
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  • 4
    Electronic Resource
    Electronic Resource
    A model for the activated sludge process which considers wastewater characteristics, floc behavior, and microbial population (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 352-361 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model has been developed which describes organics removal, oxygen utilization, ammonianitrogen removal, ortho-phosphate removal, and biomass production in an aggregated microbial suspension containing a uniform floc size and the organics as a soluble biodegradable material. It is applicable to both steady-state and transient conditions, as well as to systems experiencing only carbon oxidation or to systems experiencing both carbon oxidation and nitrification. The model, consisting of five partial differential equations and four ordinary differential equations, takes into account the flow pattern in the reactor, intraparticle mass transport of oxygen, organics, ammonia-nitrogen and ortho-phosphate, and biochemical reactions by the individual cells embedded in the floc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260260410
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  • 5
    Electronic Resource
    Electronic Resource
    A kinetic model for the activated sludge process which considers diffusion and reaction in the microbial floc (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 25 (1983), S. 2591-2615 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model has been developed which describes substrate removal, oxygen utilization, and biomass production in an aggregated microbial suspension containing the substrate as a soluble biodegradable material and a uniform floc size. It is applicable to both steady-state and transient conditions. The model, consisting of three partial differential equations and two ordinary differential equations, takes into account the flow pattern in the reactor, intraparticle mass transport of oxygen and substrate, and biochemical reaction by individual cells embedded in the floc. Efficient numerical solution of the coupled nonlinear equations is obtained using an implicit finite difference approach for both the reactor and floc equations. A convergent solution is realized through block interation utilizing the tridiagonal algorithm. Results indicate that a unifying theory of activated sludge dynamics will have to consider coupling between floc chemical kinetics and changes in the bulk liquid characteristics. Floc size emerges as an important influence on system performance. It appears necessary to distinguish between a system response caused by diffuslonal resistances and nutrient limitations within the floc and a response caused by physiological adaption when analyzing the transient behavior of an activated sludge process. Future research should be devoted to rigorous laboratory determinations of model parameters along with extensions to include limitations of nutrients other than orgabnic carbon and oxygen.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260251109
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis and properties of new luminescent acridinium-9-carboxylic acid derivatives and their application in luminescence immunoasays (LIA) (1989)
    New York : Wiley-Blackwell
    Journal of Bioluminescence and Chemiluminescence 4 (1989), S. 136-139 
    Details
    ISSN: 0884-3996
    Keywords: Luminescent labels ; acridinium-9-thiocarboxylates ; acridinium-9-(N-sulphonyl)carboxamides ; emission kinetics ; tracer stabilities ; immunoassays ; hCG ; TSH ; AFP ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bio.1170040120
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  • 7
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Konformation und elektronischen Struktur von Cyclooctadieninen (1985)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 118 (1985), S. 210-220 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Investigations on the Conformation and the Electronic Structure of CyclooctadienynesConformations and electronic structures of the cyclooctadienynes 1 and 2, predicted by semi-empirical quantum mechanics, are verified experimentally with the aid of 1H NMR and PE spectra. The results are correlated with those of other cycloalkynes 3-5 and cycloalkenes 6-11. In contrast to the decisive influence of the high geometrical ring strain in 1 and 2, homoaromaticity based on six almost planar π-electron centres is not significant.
    Notes: Die mit semiempirischer Quantenmechanik vorhergesagten Konformationen und elektronischen Strukturen der Cyclooctadienine 1 und 2 werden experimentell an Hand von 1H-NMR- und PE-Spektren verifiziert. Dabei wird Bezug genommen auf eine Reihe von anderen, verwandten Cycloalkinen 3-5 und Cycloalkenen 6-11. Während die hohe geometrische Ringspannung entscheidenden Einfluß auf 1 und 2 hat, ist eine Homoaromatizität, die auf sechs nahezu eben angeordneten π-Elektronen-Zentren beruht, nicht signifikant.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19851180120
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetische Untersuchungen zu Diels-Alder-Reaktionen des Cyclooctins mit anschließender Aromatisierung (1984)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 117 (1984), S. 833-839 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Kinetic Investigations of Diels-Alder-Reactions of Cyclooctyne with Consecutive AromatizationThe tricyclic compounds 3a - g, generated from cyclooctyne (1) and the cyclic dienes 2a - g, show a totally different stability. 3a, b, f, and g decompose spontaneously. By elimination of CO2, SO2, CO, and N2, respectively, the aromatic systems 4a - c are formed. 3e loses C2H4 on heating. 3e is thermally cleaved only to a very small extent, but efficiently in the photolysis and finally 3d is stable against aromatization. Detailed kinetical measurements are performed of the thermal elimination of ethylene and of the photochemical bisdecarbonylation.
    Notes: Aus Cyclooctin (1) und den cyclischen Dienen 2a - g entstehen die Tricyclen 3a - g, die ganz unterschiedliche Stabilität aufweisen. 3a, b, f und g zerfallen spontan. Unter Abspaltung von CO2, SO2, CO und N2 entstehen die aromatischen Verbindungen 4a - c. 3c eliminiert beim Erhitzen C2H4. 3e wird thermisch kaum mehr gespalten, aber ganz effizient bei der Photolyse, und 3d ist schließlich gegenüber einer Aromatisierung stabil. Die thermische Ethylenabspaltung und die doppelte Photodecarbonylierung werden kinetisch untersucht.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19841170234
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  • 9
    Electronic Resource
    Electronic Resource
    1,2-Dihydropentalen aus 1,6-Cyclooctadien-3-inDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft und dem Fonds der Chemischen Industrie unterstützt. (1982)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 94 (1982), S. 921-921 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No Abstract.Das vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1982, 2050-2055
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19820941209
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  • 10
    Electronic Resource
    Electronic Resource
    1,2-Dihydropentalen aus 1,6-Cyclooctadien-3-inDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft und dem Fonds der Chemischen Industrie unterstützt. (1982)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 21 (1982), S. 2050-2055 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.198220500
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