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  • 1
    Electronic Resource
    Electronic Resource
    Neither prolactin nor growth hormone restore the nocturnal rise in pineal N-acetyltransferase activity or melatonin content in hypophysectomized rats (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 509-511 
    Details
    ISSN: 1420-9071
    Keywords: Pineal gland ; hypophysectomy ; N-acetyltransferase ; melatonin ; prolactin ; growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Hypophysectomy in adult male rats greatly attenuated the nocturnal rise in both pineal N-acetyltransferase (NAT) activity and melatonin content. High nighttime levels of NAT and melatonin were not restored by treating the animals with either prolactin or growth hormone, alone or in combination. Treating intact rats with bromocriptine, which depresses circulating prolactin levels, also was without effect on pineal melatonin synthesis. It appears that neither prolactin nor growth hormone are of major importance in determining pineal melatonin production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958931
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  • 2
    Electronic Resource
    Electronic Resource
    Melatonin and 6-methoxy-2-benzoxazolinone (6-MBOA) alter the response of the male Syrian hamster to natural photoperiod (1988)
    Springer
    International journal of biometeorology 32 (1988), S. 103-107 
    Details
    ISSN: 1432-1254
    Keywords: 6-Methoxy-2-benzoxazolinone ; 6-MBOA ; Melatonin ; Hamster ; Natural photoperiod
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Adult male hamsters bearing either a blank beeswax, 6-methoxy-2-benzoxazolinone (6-MBOA), or melatonin pellet were exposed to 8 weeks (Oct. 6–Dec. 6) of natural autumn decreasing photoperiod (〈11 h light) and temperature conditions (mean 10°C for last 4 weeks) or to a 14 h light/10 h dark (14L∶10D) photoperiod and controlled temperature (20°C). Melatonin but not 6-MBOA pellets partially prevented the combined effects of short photoperiod and cold temperatures on the testes and accessory organs. However, both 6-MBOA-and melatonin-treated hamsters maintained outdoors had significantly higher pituitary follicle stimulating hormone (FSH) values compared to their respective indoor-treated controls or to the animals kept outdoors and treated with a blank beeswax pellet. When one compares the various effects of 6-MBOA and melatonin (2 mg/month) on the reproductive system of the male hamster, 6-MBOA is not as effective as melatonin in altering reproductive responses to short photoperiod and cool temperatures at the dose administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01044902
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  • 3
    Electronic Resource
    Electronic Resource
    Nyctohemeral rhythmicity of type II thyroxine 5′-deiodinase activity in the pineal gland but not in the Harderian gland of the Swiss mouse (1991)
    Springer
    Bioscience reports 11 (1991), S. 111-117 
    Details
    ISSN: 1573-4935
    Keywords: deiodinase ; thyroxine ; Swiss mouse ; pineal ; Harderian
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Type II thyroxine 5′-deiodinase (5′-D) activity in both pineal and Harderian glands of the Swiss mouse was studied. Pineal 5′-D activity exhibited a nyctohemeral profile with a maximal peak value at 05.00 h, which coincides with that for pineal melatonin production. However, no rhythm of 5′-D activity in the Harderian gland could be found. In pineal gland, light at night inhibited the nocturnal increase in 5′-D activity, while isoproterenol, a β-adrenergic agonist, could not stimulate the enzyme. In the Harderian gland, neither darkness, nor light at night, or isoproterenol were capable of modifying basal values of 5′-D activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01119198
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  • 4
    Electronic Resource
    Electronic Resource
    Role of Pinoline and Melatonin in Stabilizing Hepatic Microsomal Membranes against Oxidative Stress (1999)
    Springer
    Journal of bioenergetics and biomembranes 31 (1999), S. 609-616 
    Details
    ISSN: 1573-6881
    Keywords: Pinoline ; melatonin ; lipid peroxidation ; membrane fluidity ; microsome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract We investigated the influence of pinoline (0.01–1.5 mM) on microsomal membrane fluiditybefore and after rigidity was induced by oxidative stress. In addition, we tested the effect ofpinoline in the presence of 1 mM melatonin. The fluidity in rat hepatic microsomes wasmonitored using fluorescence spectroscopy and it was compared to the inhibition ofmalonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) production as a reflection of lipid peroxidation.Below 0.6 mM, pinoline inhibited membrane rigidity in a manner parallel to its inhibitoryeffect on MDA + 4−HDA formation. At concentrations between 1–1.5 mM, pinoline wasless effective in stabilizing microsomal membranes than was predicted from its inhibition oflipid peroxidation. The addition of 1 mM melatonin enhanced the membrane-stabilizing activityof pinoline (0.01–0.6 mM). This cooperative effect was not observed for concentrations ofpinoline between 1–1.5 mM. When pinoline was tested without induced oxidative damage,1–1.5 mM pinoline maintained membrane fluidity at the same level as that recorded afterinduced lipid peroxidation. The results suggest that pinoline may be another pineal moleculethat prevents membrane rigidity mediated by lipid peroxidation and this ability is enhancedby melatonin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005425213253
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