ISSN:
0021-9304
Keywords:
thermogravimetry
;
differential thermal analysis
;
activation energy
;
ovariectomy
;
traditional Chinese medicine
;
17β-estradiol
;
rat
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
Thermal analyses [thermogravimetry (TG) and differential thermal analysis (DTA)], X-ray diffraction, and infrared absorption analysis of bones from ovariectomized rats were carried out. The rats were divided into five groups: sham operated (Sham); ovariectomized (OVX); OVX given traditional Chinese (Kampo) medicine, Unkei-to; OVX given 17β-estradiol; and OVX given the estradiol vehicle, respectively. The activation energy (ΔE), a kinetic parameter from TG data of OVX rats, increased by 57% from that in Sham rats. The administration of Unkei-to and 17β-estradiol to OVX rats clearly restored the ΔE to the levels of Sham rats, while the vehicle for 17β-estradiol had no effect. DTA data from thermal analyses of rats from the Sham, OVX, and OVX given various compounds were almost the same except for OVX rats given 17β-estradiol. The X-ray diffraction pattern and infrared absorption spectrum of bone powders from Sham rats were not different from those of OVX rats or others. These results strongly suggest that a kinetic parameter, ΔE calculated from TG data, may be a useful method for assessing both experimentally induced osteoporosis and drug effects on it. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 221-226, 1998.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
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