Skip to main content

Advertisement

Log in

Preventive Effects of Traditional Chinese (Kampo) Medicines on Experimental Osteoporosis Induced by Ovariectomy in Rats

  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Abstract.

Preventive effects by traditional Chinese (Kampo) medicines, Unkei-to, Hachimi-jio-gan, and Juzen-taiho-to, on the progress of bone loss induced by ovariectomy in rats were investigated for a period of 49 days. The bone mineral density (BMD) of tibia in ovariectomized (OVX) rats decreased by 20% from those in sham-operated (Sham) rats, with the decrease completely inhibited by the administration of any one of these Kampo medicines or 17β-estradiol. From scanning electron microscopic (SEM) analyses, the surface of a trabecular bone of tibia in OVX rats had a porous or erosive appearance, whereas that of the same bone in Sham rats was composed of fine particles. The administration of three Kampo medicines and 17β-estradiol to OVX rats preserved the fine particle surface of the trabecular bone. These results strongly suggest that any of these three gynecological Kampo medicines is as effective as 17β-estradiol in preventing the development of bone loss induced by ovariectomy in rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Author information

Authors and Affiliations

Authors

Additional information

Received: 18 December 1995 / Accepted: 24 September 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hidaka, S., Okamoto, Y., Nakajima, K. et al. Preventive Effects of Traditional Chinese (Kampo) Medicines on Experimental Osteoporosis Induced by Ovariectomy in Rats . Calcif Tissue Int 61 , 239 –246 (1997). https://doi.org/10.1007/s002239900329

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002239900329

Navigation