Publikationsdatum:
2001-02-07
Beschreibung:
Biofilms are formed by the aggregation of microorganisms into multicellular structures that adhere to surfaces. Here we show that bakers' yeast Saccharomyces cerevisiae can initiate biofilm formation. When grown in low-glucose medium, the yeast cells adhered avidly to a number of plastic surfaces. On semi-solid (0.3% agar) medium they formed "mats": complex multicellular structures composed of yeast-form cells. Both attachment to plastic and mat formation require Flo11p, a member of a large family of fungal cell surface glycoproteins involved in adherence. The ability to study biofilm formation in a tractable genetic system may facilitate the identification of new targets for antifungal therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reynolds, T B -- Fink, G R -- 5 RO1 GM40266/GM/NIGMS NIH HHS/ -- GM20565/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):878-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11157168" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Agar
;
Biofilms/*growth & development
;
Cell Adhesion
;
Culture Media
;
Fungal Proteins/genetics/physiology
;
Genes, Fungal
;
Glucose
;
Lipoproteins/physiology
;
MAP Kinase Signaling System/genetics/physiology
;
Membrane Glycoproteins
;
Membrane Proteins/genetics/physiology
;
*Nuclear Proteins
;
Peptides/physiology
;
Pheromones
;
Plastics
;
Ploidies
;
Saccharomyces cerevisiae/genetics/growth & development/*physiology
;
*Saccharomyces cerevisiae Proteins
;
Trans-Activators/genetics/physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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