Publikationsdatum:
1978-03-17
Beschreibung:
With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204008" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Action Potentials/drug effects
;
Animals
;
Cats
;
Decerebrate State
;
Dose-Response Relationship, Drug
;
Morphine/*pharmacology
;
Naloxone/*pharmacology
;
Nerve Fibers/physiology
;
Nociceptors/*drug effects/physiology
;
Receptors, Opioid/*physiology
;
Spinal Cord/physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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