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  • ASTROPHYSICS  (3)
  • Condensed Matter: Structure, etc.  (2)
  • Mice, Inbred C57BL  (2)
  • inclusion complex  (2)
  • *Insecticides/pharmacology  (1)
  • 1
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    New Structural Picture of the Ge_{2} Sb_{2} Te_{5} Phase-Change Alloy (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-01-14
    Description: Author(s): X. Q. Liu, X. B. Li, L. Zhang, Y. Q. Cheng, Z. G. Yan, M. Xu, X. D. Han, S. B. Zhang, Z. Zhang, and E. Ma Using electron microscopy and diffraction techniques, as well as first-principles calculations, we demonstrate that as much as 35% of the total Ge atoms in the cubic phase of Ge_{2} Sb_{2} Te_{5} locate in tetrahedral environments. The Ge-vacancy interactions play a crucial stabilizing role, leading... [Phys. Rev. Lett. 106, 025501] Published Thu Jan 13, 2011
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    A core metabolic enzyme mediates resistance to phosphine gas (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-10
    Description: Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schlipalius, David I -- Valmas, Nicholas -- Tuck, Andrew G -- Jagadeesan, Rajeswaran -- Ma, Li -- Kaur, Ramandeep -- Goldinger, Anita -- Anderson, Cameron -- Kuang, Jujiao -- Zuryn, Steven -- Mau, Yosep S -- Cheng, Qiang -- Collins, Patrick J -- Nayak, Manoj K -- Schirra, Horst Joachim -- Hilliard, Massimo A -- Ebert, Paul R -- R01NS060129/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):807-10. doi: 10.1126/science.1224951.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, Ecosciences Precinct, Brisbane, QLD 4001, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23139334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arsenicals/pharmacology ; Arsenites/pharmacology ; Beetles/drug effects/*enzymology/genetics/metabolism ; Caenorhabditis elegans/drug effects/*enzymology/genetics/metabolism ; Caenorhabditis elegans Proteins/chemistry/genetics/metabolism ; Catalytic Domain ; Dihydrolipoamide Dehydrogenase/chemistry/*genetics/metabolism ; Insect Proteins/chemistry/genetics/metabolism ; Insecticide Resistance/*genetics ; *Insecticides/pharmacology ; Metabolic Networks and Pathways ; Molecular Sequence Data ; Mutation ; Oxidation-Reduction ; Pesticides ; *Phosphines/pharmacology ; Polymorphism, Genetic ; Protein Multimerization ; Tribolium/drug effects/*enzymology/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-02-18
    Description: Inflammatory mechanisms influence tumorigenesis and metastatic progression even in cancers whose aetiology does not involve pre-existing inflammation or infection, such as breast and prostate cancers. For instance, prostate cancer metastasis is associated with the infiltration of lymphocytes into advanced tumours and the upregulation of two tumour-necrosis-factor family members: receptor activator of nuclear factor-kappaB (RANK) ligand (RANKL) and lymphotoxin. But the source of RANKL and its role in metastasis have not been established. RANKL and its receptor RANK control the proliferation of mammary lobuloalveolar cells during pregnancy through inhibitor of nuclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that is needed for the self-renewal of mammary cancer progenitors and for prostate cancer metastasis. We therefore examined whether RANKL, RANK and IKK-alpha are also involved in mammary/breast cancer metastasis. Indeed, RANK signalling in mammary carcinoma cells that overexpress the proto-oncogene Erbb2 (also known as Neu), which is frequently amplified in metastatic human breast cancers, was important for pulmonary metastasis. Metastatic spread of Erbb2-transformed carcinoma cells also required CD4(+)CD25(+) T cells, whose major pro-metastatic function was RANKL production. Most RANKL-producing T cells expressed forkhead box P3 (FOXP3), a transcription factor produced by regulatory T cells, and were located next to smooth muscle actin (SMA)(+) stromal cells in mouse and human breast cancers. The dependence of pulmonary metastasis on T cells was replaceable by exogenous RANKL, which also stimulated pulmonary metastasis of RANK(+) human breast cancer cells. These results are consistent with the adverse impact of tumour-infiltrating CD4(+) or FOXP3(+) T cells on human breast cancer prognosis and suggest that the targeting of RANKL-RANK can be used in conjunction with the therapeutic elimination of primary breast tumours to prevent recurrent metastatic disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166217/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166217/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tan, Wei -- Zhang, Weizhou -- Strasner, Amy -- Grivennikov, Sergei -- Cheng, Jin Q -- Hoffman, Robert M -- Karin, Michael -- R01 CA127923/CA/NCI NIH HHS/ -- R01 CA127923-05/CA/NCI NIH HHS/ -- R01 CA132586/CA/NCI NIH HHS/ -- T32 CA121938/CA/NCI NIH HHS/ -- England -- Nature. 2011 Feb 24;470(7335):548-53. doi: 10.1038/nature09707. Epub 2011 Feb 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21326202" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD4/genetics/metabolism ; Antigens, CD8/genetics/metabolism ; Breast Neoplasms/*metabolism/*pathology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Female ; Forkhead Transcription Factors/metabolism ; Genes, RAG-1/genetics ; Humans ; I-kappa B Kinase/metabolism ; Lung Neoplasms/metabolism/secondary ; Lymphocytes, Tumor-Infiltrating/*metabolism ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/pathology ; RANK Ligand/antagonists & inhibitors/*metabolism/pharmacology ; Receptor Activator of Nuclear Factor-kappa B/deficiency/genetics/*metabolism ; Receptor, ErbB-2/genetics/metabolism ; *Signal Transduction/drug effects ; T-Lymphocytes, Regulatory/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Medial prefrontal activity during delay period contributes to learning of a working memory task (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-10-25
    Description: Cognitive processes require working memory (WM) that involves a brief period of memory retention known as the delay period. Elevated delay-period activity in the medial prefrontal cortex (mPFC) has been observed, but its functional role in WM tasks remains unclear. We optogenetically suppressed or enhanced activity of pyramidal neurons in mouse mPFC during the delay period. Behavioral performance was impaired during the learning phase but not after the mice were well trained. Delay-period mPFC activity appeared to be more important in memory retention than in inhibitory control, decision-making, or motor selection. Furthermore, endogenous delay-period mPFC activity showed more prominent modulation that correlated with memory retention and behavioral performance. Thus, properly regulated mPFC delay-period activity is critical for information retention during learning of a WM task.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Ding -- Gu, Xiaowei -- Zhu, Jia -- Zhang, Xiaoxing -- Han, Zhe -- Yan, Wenjun -- Cheng, Qi -- Hao, Jiang -- Fan, Hongmei -- Hou, Ruiqing -- Chen, Zhaoqin -- Chen, Yulei -- Li, Chengyu T -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):458-63. doi: 10.1126/science.1256573.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience and Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. University of Chinese Academy of Sciences, Beijing 100049, China. ; Institute of Neuroscience and Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. ; Institute of Neuroscience and Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. tonylicy@ion.ac.cn.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342800" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism ; Learning/*physiology ; Luminescent Proteins/genetics/metabolism ; Male ; Memory, Short-Term/*physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Prefrontal Cortex/cytology/*physiology ; Pyramidal Cells/*physiology ; Reaction Time ; *Retention (Psychology) ; Rhodopsin/genetics/metabolism ; Smell
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    First-Order Liquid-Liquid Phase Transition in Cerium (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-03-22
    Description: Author(s): A. Cadien, Q. Y. Hu, Y. Meng, Y. Q. Cheng, M. W. Chen, J. F. Shu, H. K. Mao, and H. W. Sheng We report the first experimental observation of a liquid-liquid phase transition in the monatomic liquid metal cerium, by means of in situ high-pressure high-temperature x-ray diffraction experiments. At 13 GPa, upon increasing temperature from 1550 to 1900 K high-density liquid transforms to a low-... [Phys. Rev. Lett. 110, 125503] Published Thu Mar 21, 2013
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetic Studies on the Thermal Dissociation of β-Cyclodextrin·Ethyl Benzoate Inclusion Complexes (1998)
    Springer
    Journal of thermal analysis and calorimetry 54 (1998), S. 947-956 
    Details
    ISSN: 1572-8943
    Keywords: β-cyclodextrin ; ethyl benzoate ; inclusion complex ; kinetics ; thermal decomposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The stability of β-cyclodextrin·ethyl benzoate·6H2O(β-CD·C6H5COOC2H5·6H2O) was investigated by TG and DSC. The mass loss takes place in three stages: the dehydration occurs at 50-120°C; the dissociation of β-CD·C6H5COOC2H5occurs at 200-260°C; the decomposition of β-CD begins at 280°C. The kinetics of the dissociation of β-CD·C6H5COOC2H5in a dry nitrogen flow was studied by means of thermogravimetry both at constant temperature and linearly increasing temperature. The results show that the dissociation of β-CD·C6H5COOC2H5is dominated by a three-dimensional diffusion process (D3). The activation energy E is 116.19 kJ mol-1and the pre-exponential factor A 6.5358·109min-1. Cyclodextrin is able to form inclusion complexes with a great variety of guest molecules, and the studies focus on the energy of binding between cyclodextrin and the guest molecule. In this paper, the β-cyclodextrin·ethyl benzoate inclusion complex was studied by fluorescence spectrophotometry and infrared absorption spectroscopy, and the results show that the stable energy of inclusion complexes of β-CD with weakly polar guest molecules consists mainly of van der Waals interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010129028436
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  • 7
    Electronic Resource
    Electronic Resource
    Mechanism and Kinetics of Thermal Dissociation of Inclusion Complex of Benzaldehyde with β-Cyclodextrin (1998)
    Springer
    Journal of thermal analysis and calorimetry 53 (1998), S. 825-833 
    Details
    ISSN: 1572-8943
    Keywords: benzaldehyde ; β-cyclodextrin ; inclusion complex ; kinetics ; mechanism ; thermal dissociation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The inclusion complex of benzaldehyde (BA) with β-cyclodextrin (β-CD) was prepared and was studied by thermal analysis and X-ray diffractometry. The composition of the complex was identified by TG and elemental analysis as β-CD·BA·9H2O. TG and DSC studies showed that the thermal dissociation of β-CD·BA·9H2O took place in three stages: dehydration in the range 70-120°C; dissociation of β-CD·BA in the range 235-270°C; and decomposition of β-CD above 280°C. The kinetics of dissociation of β-CD·BA in flowing dry nitrogen was studied by means of TG both at constant temperature and at linearly increasing temperature. The results showed that the dissociation of β-CD·BA was dominated by a one-dimensional random nucleation and subsequent growth process (A2). The activation energy E was 124. 8 kJ mol-1, and the pre-exponential factor A 5.04·1011 min-1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010142828201
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  • 8
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    Acoustic waves in M dwarfs: Maintaining a corona (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: We use a time-dependent hydrodynamics code to follow the propagation of acoustic waves into the corona of an M dwarf star. An important qualitative difference between M dwarfs and stars such as the Sun is that the acoustic spectrum in M dwarfs is expected to peak at periods close to the acoustic cutoff P(sub A): this allows more effective penetration of waves into the corona. In our code, radiative losses in the photosphere, chromosphere, and corona are computed using Rosseland mean opacities, Mg II kappa and Ly alpha emission, and optically thin emissivities respectively. We find that acoustic heating can maintain a corona with a temperature of order 0.7-1 x 10(exp 6) K and a surface X-ray flux as large as 10(exp 5)ergs/sq cm/s. In a recent survey of X-rays from M dwarfs, some (20%-30%) of the stars lie at or below this limiting X-ray flux: we suggest that such stars may be candidates for acoustically maintained coronae.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 420; 1; p. 392-400
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  • 9
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    Mg II and Ly-alpha fluxes in M dwarfs - Evaluation of an acoustic model (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: Surface fluxes of Mg II and Ly-alpha from a sample of M dwarfs have been reported by Panagi and Mathioudakis (PM, 1992). In order to determine if acoustic effects can reproduce the fluxes in the least active ('basal') stars in the PM sample, we have constructed steady state models of plane-parallel atmospheres with T(eff) = 3000 and 4000 K including heating by shock dissipation. The models incorporate radiative losses in the chromosphere by solving the transfer equation for two strong lines (Mg II k and Ly-alpha). Predictions of standard weak shock theory are expected to overestimate the rate of energy deposition in the chromospheres of M dwarfs compared to the rate of deposition in F, G, or K dwarfs. In order to incorporate this effect in M dwarfs, we compute a series of atmospheric models in which, for a given T(eff), the standard weak shock dissipation rate is reduced by a series of factors F(r). Although the input acoustic flux F(mech) may in principle be determined uniquely by T(eff) and log g, the correct value to use in any particular case is not well known. We therefore use F(mech) and F(r) as parameters to construct a family of M dwarf models at various T(eff) and g. Comparing with the observed fluxes in the least active M dwarfs of the PM sample, we find that our models reproduce the observed fluxes of both Mg II and Ly-alpha best if F(mech) is close to the value predicted by Bohn (1984) and if F(r) is approximately equal to 10-20.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 412; 1; p. 312-323.
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  • 10
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    Acoustic heating of the chromosphere and cool corona in the F star alpha Canis Minoris (Procyon) (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: We report on a hydrodynamical model of acoustic wave energy deposition in the atmosphere of the F star Procyon. The model treats radiative losses in the photosphere by solving the continuum radiative transfer (RT) problem; it treats radiative losses in the chromosphere by solving the RT equation in two representative strong lines (Mg II k and Lyman alpha); and it includes optically thin emission from the corona. We find a temperature minimum of 4440 K and a transition region at a height of 3500-4000 km above the photosphere. Our acoustic model accounts for the reported fluxes of Mg II and Lyman alpha emission lines, as well as for the X-ray flux from the cool (T less than 1 MK) coronal component reported by Lemen et al. (1989). The differential emission measure distribution in our model agrees quite well with empirical results of Jordan et al. (1986).
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 435; 1; p. 435-448
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