Publication Date:
2008-10-10
Description:
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651158/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651158/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlton, Jane M -- Adams, John H -- Silva, Joana C -- Bidwell, Shelby L -- Lorenzi, Hernan -- Caler, Elisabet -- Crabtree, Jonathan -- Angiuoli, Samuel V -- Merino, Emilio F -- Amedeo, Paolo -- Cheng, Qin -- Coulson, Richard M R -- Crabb, Brendan S -- Del Portillo, Hernando A -- Essien, Kobby -- Feldblyum, Tamara V -- Fernandez-Becerra, Carmen -- Gilson, Paul R -- Gueye, Amy H -- Guo, Xiang -- Kang'a, Simon -- Kooij, Taco W A -- Korsinczky, Michael -- Meyer, Esmeralda V-S -- Nene, Vish -- Paulsen, Ian -- White, Owen -- Ralph, Stuart A -- Ren, Qinghu -- Sargeant, Tobias J -- Salzberg, Steven L -- Stoeckert, Christian J -- Sullivan, Steven A -- Yamamoto, Marcio M -- Hoffman, Stephen L -- Wortman, Jennifer R -- Gardner, Malcolm J -- Galinski, Mary R -- Barnwell, John W -- Fraser-Liggett, Claire M -- N01 AI030071/AI/NIAID NIH HHS/ -- R01 AI064478/AI/NIAID NIH HHS/ -- R01 AI064478-05/AI/NIAID NIH HHS/ -- R01 GM070793/GM/NIGMS NIH HHS/ -- R01 GM070793-01A2/GM/NIGMS NIH HHS/ -- R01 GM083873/GM/NIGMS NIH HHS/ -- R01 LM006845/LM/NLM NIH HHS/ -- R01 LM006845-09/LM/NLM NIH HHS/ -- England -- Nature. 2008 Oct 9;455(7214):757-63. doi: 10.1038/nature07327.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA. jane.carlton@nyumc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18843361" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Motifs
;
Animals
;
Artemisinins/metabolism/pharmacology
;
Atovaquone/metabolism/pharmacology
;
Cell Nucleus/genetics
;
Chromosomes/genetics
;
Conserved Sequence/genetics
;
Erythrocytes/parasitology
;
Evolution, Molecular
;
Genome, Protozoan/*genetics
;
*Genomics
;
Haplorhini/parasitology
;
Humans
;
Isochores/genetics
;
Ligands
;
Malaria, Vivax/metabolism/*parasitology
;
Multigene Family
;
Plasmodium vivax/drug effects/*genetics/pathogenicity/physiology
;
Sequence Analysis, DNA
;
Species Specificity
;
Synteny/genetics
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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