Publication Date:
2004-10-23
Description:
When considering the daunting complexity of eukaryotic genomes, some comfort can be found in the fact that the human genome may contain only 30,000 to 40,000 genes. Moreover, growing evidence suggests that genomes may be organized in such a way as to take advantage of space. A gene's location in the linear DNA sequence and its position in the three-dimensional nucleus can both be important in its regulation. Contrary to prevailing notions in this postgenomic era, the bacteriophage lambda, a paragon of simplicity, may still have a few things to teach us with respect to these facets of nonrandom genomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kosak, Steven T -- Groudine, Mark -- New York, N.Y. -- Science. 2004 Oct 22;306(5696):644-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15499009" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bacteriophage lambda/genetics
;
Cell Cycle
;
Cell Nucleus/physiology
;
Chromosomes/genetics/physiology
;
Chromosomes, Human/genetics/physiology
;
*Gene Expression Regulation
;
Gene Expression Regulation, Viral
;
*Gene Order
;
*Genome
;
Genome, Human
;
Genome, Viral
;
Humans
;
Multigene Family
;
Transcription Factors/metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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