Publication Date:
2003-09-13
Description:
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bleharski, Joshua R -- Li, Huiying -- Meinken, Christoph -- Graeber, Thomas G -- Ochoa, Maria-Teresa -- Yamamura, Masahiro -- Burdick, Anne -- Sarno, Euzenir N -- Wagner, Manfred -- Rollinghoff, Martin -- Rea, Thomas H -- Colonna, Marco -- Stenger, Steffen -- Bloom, Barry R -- Eisenberg, David -- Modlin, Robert L -- AI 07118/AI/NIAID NIH HHS/ -- AI 22553/AI/NIAID NIH HHS/ -- AI 47868/AI/NIAID NIH HHS/ -- AR 40312/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Sep 12;301(5639):1527-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12970564" target="_blank"〉PubMed〈/a〉
Keywords:
Algorithms
;
Cluster Analysis
;
Colony Count, Microbial
;
Cytokines/genetics/metabolism
;
*Gene Expression Profiling
;
*Gene Expression Regulation
;
Genes, Immunoglobulin
;
Humans
;
Immunity, Cellular
;
Immunity, Innate
;
Leprosy, Lepromatous/*classification/*genetics/immunology/physiopathology
;
Leprosy, Tuberculoid/*classification/*genetics/immunology/physiopathology
;
Macrophages, Alveolar/microbiology
;
Membrane Glycoproteins/immunology
;
Mycobacterium tuberculosis/growth & development/immunology
;
Oligonucleotide Array Sequence Analysis
;
Polymerase Chain Reaction
;
Principal Component Analysis
;
Receptors, Cell Surface/immunology
;
Receptors, Immunologic/genetics/metabolism
;
Toll-Like Receptors
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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