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  • 1
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    Suppression of the microRNA pathway by bacterial effector proteins (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-08-16
    Description: Plants and animals sense pathogen-associated molecular patterns (PAMPs) and in turn differentially regulate a subset of microRNAs (miRNAs). However, the extent to which the miRNA pathway contributes to innate immunity remains unknown. Here, we show that miRNA-deficient mutants of Arabidopsis partly restore growth of a type III secretion-defective mutant of Pseudomonas syringae. These mutants also sustained growth of nonpathogenic Pseudomonas fluorescens and Escherichia coli strains, implicating miRNAs as key components of plant basal defense. Accordingly, we have identified P. syringae effectors that suppress transcriptional activation of some PAMP-responsive miRNAs or miRNA biogenesis, stability, or activity. These results provide evidence that, like viruses, bacteria have evolved to suppress RNA silencing to cause disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570098/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570098/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Navarro, Lionel -- Jay, Florence -- Nomura, Kinya -- He, Sheng Yang -- Voinnet, Olivier -- 5R01AI060761/AI/NIAID NIH HHS/ -- R01 AI060761/AI/NIAID NIH HHS/ -- R01 AI060761-03/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2008 Aug 15;321(5891):964-7. doi: 10.1126/science.1159505.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire des Plantes, CNRS UPR 2353-Universite Louis Pasteur, 12 Rue du General Zimmer, 67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18703740" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics/immunology/*microbiology/virology ; Bacterial Proteins/*metabolism ; Escherichia coli/growth & development ; Immunity, Innate ; MicroRNAs/genetics/*metabolism ; Mutation ; Plant Diseases/immunology/*microbiology ; Plant Leaves/metabolism/microbiology ; Plants, Genetically Modified ; Potyvirus/physiology ; Pseudomonas fluorescens/growth & development ; Pseudomonas syringae/genetics/*growth & development/metabolism/pathogenicity ; RNA Interference ; RNA Stability ; RNA, Plant/genetics/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A small-RNA perspective on gametogenesis, fertilization, and early zygotic development (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-30
    Description: Transient populations of cis- and trans-acting small RNAs have recently emerged as key regulators of extensive epigenetic changes taking place during periconception, which encompasses gametogenesis, fertilization, and early zygotic development. These small RNAs are not only important to maintain genome integrity in the gametes and zygote, but they also actively contribute to assessing the compatibility of parental genomes at fertilization and to promoting long-term memory of the zygotic epigenetic landscape by affecting chromatin. Striking parallels exist in the biogenesis and modus operandi of these molecules among diverse taxa, unraveling universal themes of small-RNA-mediated epigenetic reprogramming during sexual reproduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourc'his, Deborah -- Voinnet, Olivier -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):617-22. doi: 10.1126/science.1194776.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris cedex 05, France. Deborah.Bourchis@curie.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030645" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/genetics/metabolism/physiology ; Animals ; Ciliophora/genetics/metabolism/physiology ; *Epigenesis, Genetic ; *Fertilization ; *Gametogenesis ; Gametogenesis, Plant ; Hybridization, Genetic ; Mammals/genetics/metabolism/physiology ; RNA, Plant/genetics/metabolism ; RNA, Small Interfering/*genetics/metabolism ; Zygote/*growth & development/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Small RNA duplexes function as mobile silencing signals between plant cells (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-24
    Description: In the plant RNA interference (RNAi) pathway, 21-nucleotide duplexes of small interfering RNA (siRNA) are processed from longer double-stranded RNA precursors by the RNaseIII Dicer-like 4 (DCL4). Single-stranded siRNAs then guide Argonaute 1 (AGO1) to execute posttranscriptional silencing of complementary target RNAs. RNAi is not cell-autonomous in higher plants, but the nature of the mobile nucleic acid(s) signal remains unknown. Using cell-specific rescue of DCL4 function and cell-specific inhibition of RNAi movement, we genetically establish that exogenous and endogenous siRNAs, as opposed to their precursor molecules, act as mobile silencing signals between plant cells. We further demonstrate physical movement of mechanically delivered, labeled siRNA duplexes that functionally recapitulate transgenic RNAi spread. Cell-to-cell movement is unlikely to involve AGO1-bound siRNA single strands, but instead likely involves siRNA duplexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunoyer, Patrice -- Schott, Gregory -- Himber, Christophe -- Meyer, Denise -- Takeda, Atsushi -- Carrington, James C -- Voinnet, Olivier -- AI43288/AI/NIAID NIH HHS/ -- R37 AI043288/AI/NIAID NIH HHS/ -- R37 AI043288-14/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 May 14;328(5980):912-6. doi: 10.1126/science.1185880. Epub 2010 Apr 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg 12 rue du General Zimmer, 67084 Strasbourg cedex, France. patrice.dunoyer@ibmp-ulp.u-strasbg.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20413458" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*cytology/*genetics/metabolism ; Arabidopsis Proteins/genetics/metabolism ; Argonaute Proteins ; DNA-Binding Proteins/genetics/metabolism ; Green Fluorescent Proteins/genetics ; Nuclear Proteins/genetics/metabolism ; Plant Leaves/cytology/genetics/metabolism ; Plants, Genetically Modified ; *RNA Interference ; RNA Precursors/metabolism ; RNA, Double-Stranded/genetics/metabolism ; RNA, Plant/genetics/*metabolism ; RNA, Small Interfering/genetics/*metabolism ; Ribonuclease III/genetics/metabolism ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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