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  • 1
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    A small-RNA perspective on gametogenesis, fertilization, and early zygotic development (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-30
    Description: Transient populations of cis- and trans-acting small RNAs have recently emerged as key regulators of extensive epigenetic changes taking place during periconception, which encompasses gametogenesis, fertilization, and early zygotic development. These small RNAs are not only important to maintain genome integrity in the gametes and zygote, but they also actively contribute to assessing the compatibility of parental genomes at fertilization and to promoting long-term memory of the zygotic epigenetic landscape by affecting chromatin. Striking parallels exist in the biogenesis and modus operandi of these molecules among diverse taxa, unraveling universal themes of small-RNA-mediated epigenetic reprogramming during sexual reproduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourc'his, Deborah -- Voinnet, Olivier -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):617-22. doi: 10.1126/science.1194776.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris cedex 05, France. Deborah.Bourchis@curie.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030645" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/genetics/metabolism/physiology ; Animals ; Ciliophora/genetics/metabolism/physiology ; *Epigenesis, Genetic ; *Fertilization ; *Gametogenesis ; Gametogenesis, Plant ; Hybridization, Genetic ; Mammals/genetics/metabolism/physiology ; RNA, Plant/genetics/metabolism ; RNA, Small Interfering/*genetics/metabolism ; Zygote/*growth & development/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Small RNA duplexes function as mobile silencing signals between plant cells (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-24
    Description: In the plant RNA interference (RNAi) pathway, 21-nucleotide duplexes of small interfering RNA (siRNA) are processed from longer double-stranded RNA precursors by the RNaseIII Dicer-like 4 (DCL4). Single-stranded siRNAs then guide Argonaute 1 (AGO1) to execute posttranscriptional silencing of complementary target RNAs. RNAi is not cell-autonomous in higher plants, but the nature of the mobile nucleic acid(s) signal remains unknown. Using cell-specific rescue of DCL4 function and cell-specific inhibition of RNAi movement, we genetically establish that exogenous and endogenous siRNAs, as opposed to their precursor molecules, act as mobile silencing signals between plant cells. We further demonstrate physical movement of mechanically delivered, labeled siRNA duplexes that functionally recapitulate transgenic RNAi spread. Cell-to-cell movement is unlikely to involve AGO1-bound siRNA single strands, but instead likely involves siRNA duplexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunoyer, Patrice -- Schott, Gregory -- Himber, Christophe -- Meyer, Denise -- Takeda, Atsushi -- Carrington, James C -- Voinnet, Olivier -- AI43288/AI/NIAID NIH HHS/ -- R37 AI043288/AI/NIAID NIH HHS/ -- R37 AI043288-14/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 May 14;328(5980):912-6. doi: 10.1126/science.1185880. Epub 2010 Apr 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg 12 rue du General Zimmer, 67084 Strasbourg cedex, France. patrice.dunoyer@ibmp-ulp.u-strasbg.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20413458" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*cytology/*genetics/metabolism ; Arabidopsis Proteins/genetics/metabolism ; Argonaute Proteins ; DNA-Binding Proteins/genetics/metabolism ; Green Fluorescent Proteins/genetics ; Nuclear Proteins/genetics/metabolism ; Plant Leaves/cytology/genetics/metabolism ; Plants, Genetically Modified ; *RNA Interference ; RNA Precursors/metabolism ; RNA, Double-Stranded/genetics/metabolism ; RNA, Plant/genetics/*metabolism ; RNA, Small Interfering/genetics/*metabolism ; Ribonuclease III/genetics/metabolism ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Widespread translational inhibition by plant miRNAs and siRNAs (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-05-17
    Description: High complementarity between plant microRNAs (miRNAs) and their messenger RNA targets is thought to cause silencing, prevalently by endonucleolytic cleavage. We have isolated Arabidopsis mutants defective in miRNA action. Their analysis provides evidence that plant miRNA-guided silencing has a widespread translational inhibitory component that is genetically separable from endonucleolytic cleavage. We further show that the same is true of silencing mediated by small interfering RNA (siRNA) populations. Translational repression is effected in part by the ARGONAUTE proteins AGO1 and AGO10. It also requires the activity of the microtubule-severing enzyme katanin, implicating cytoskeleton dynamics in miRNA action, as recently suggested from animal studies. Also as in animals, the decapping component VARICOSE (VCS)/Ge-1 is required for translational repression by miRNAs, which suggests that the underlying mechanisms in the two kingdoms are related.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodersen, Peter -- Sakvarelidze-Achard, Lali -- Bruun-Rasmussen, Marianne -- Dunoyer, Patrice -- Yamamoto, Yoshiharu Y -- Sieburth, Leslie -- Voinnet, Olivier -- New York, N.Y. -- Science. 2008 May 30;320(5880):1185-90. doi: 10.1126/science.1159151. Epub 2008 May 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire des Plantes du CNRS, Unite Propre de Recherche 2357, 12 rue du General Zimmer, 67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18483398" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/genetics/physiology ; Arabidopsis/genetics/physiology ; Arabidopsis Proteins/genetics/physiology ; Argonaute Proteins ; *Gene Expression Regulation, Plant ; Green Fluorescent Proteins/genetics ; MicroRNAs/*physiology ; Mutation ; Protein Biosynthesis ; RNA Caps ; *RNA Interference ; RNA, Plant/*physiology ; RNA, Small Interfering/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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