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  • 1
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    Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-15
    Description: Cooperation is central to many major transitions in evolution, including the emergence of eukaryotic cells, multicellularity and eusociality. Cooperation can be destroyed by the spread of cheater mutants that do not cooperate but gain the benefits of cooperation from others. However, cooperation can be preserved if cheaters are facultative, cheating others but cooperating among themselves. Several cheater mutants have been studied before, but no study has attempted a genome-scale investigation of the genetic opportunities for cheating. Here we describe such a screen in a social amoeba and show that cheating is multifaceted by revealing cheater mutations in well over 100 genes of diverse types. Many of these mutants cheat facultatively, producing more than their fair share of spores in chimaeras, but cooperating normally when clonal. These findings indicate that phenotypically stable cooperative systems may nevertheless harbour genetic conflicts. The opportunities for evolutionary moves and countermoves in such conflicts may select for the involvement of multiple pathways and numerous genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santorelli, Lorenzo A -- Thompson, Christopher R L -- Villegas, Elizabeth -- Svetz, Jessica -- Dinh, Christopher -- Parikh, Anup -- Sucgang, Richard -- Kuspa, Adam -- Strassmann, Joan E -- Queller, David C -- Shaulsky, Gad -- G0400103/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2008 Feb 28;451(7182):1107-10. doi: 10.1038/nature06558. Epub 2008 Feb 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18272966" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/genetics/physiology ; Animals ; Cell Aggregation ; Chimera/genetics/physiology ; *Cooperative Behavior ; Dictyostelium/cytology/*genetics/*physiology ; Genes, Protozoan/genetics ; Genome/genetics ; Genomics ; Mutation/*genetics ; Myxococcus xanthus/genetics/physiology ; Phenotype ; *Social Behavior ; Spores, Protozoan/genetics/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-08
    Description: Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3',5'-monophosphate (cAMP) are generated with a periodicity of 7 minutes. We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Computer modeling and simulations of the underlying circuit faithfully account for the ability of the cells to spontaneously generate periodic pulses during specific stages of development. Similar oscillatory processes may occur in cells of many different species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Mineko -- Lu, Sijie -- Shaulsky, Gad -- Miyazaki, Yuji -- Kuwayama, Hidekazu -- Tanaka, Yoshimasa -- Kuspa, Adam -- Loomis, William F -- GM52359/GM/NIGMS NIH HHS/ -- GM62350/GM/NIGMS NIH HHS/ -- R01 GM052359/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 May 7;304(5672):875-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Graduate School of Science, Osaka University, Machikaneyama-cho 1-16, Toyonaka, Osaka 560-0043, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131307" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases ; Adenylyl Cyclases/metabolism ; Animals ; Computer Simulation ; Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics/*metabolism ; Dictyostelium/enzymology/genetics/growth & development/*metabolism ; Enzyme Activation ; Mitogen-Activated Protein Kinase 1/genetics/*metabolism ; Models, Biological ; Mutagenesis, Site-Directed ; Mutation ; Phosphorylation ; Protozoan Proteins/genetics/metabolism ; Receptors, Cyclic AMP/metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Immune-like phagocyte activity in the social amoeba (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-08-04
    Description: Social amoebae feed on bacteria in the soil but aggregate when starved to form a migrating slug. We describe a previously unknown cell type in the social amoeba, which appears to provide detoxification and immune-like functions and which we term sentinel (S) cells. S cells were observed to engulf bacteria and sequester toxins while circulating within the slug, eventually being sloughed off. A Toll/interleukin-1 receptor (TIR) domain protein, TirA, was also required for some S cell functions and for vegetative amoebae to feed on live bacteria. This apparent innate immune function in social amoebae, and the use of TirA for bacterial feeding, suggest an ancient cellular foraging mechanism that may have been adapted to defense functions well before the diversification of the animals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291017/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291017/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Guokai -- Zhuchenko, Olga -- Kuspa, Adam -- GM52359/GM/NIGMS NIH HHS/ -- HD39691/HD/NICHD NIH HHS/ -- P01 HD039691/HD/NICHD NIH HHS/ -- P01 HD039691-03/HD/NICHD NIH HHS/ -- P01 HD039691-04/HD/NICHD NIH HHS/ -- P01 HD039691-05/HD/NICHD NIH HHS/ -- P01 HD039691-06/HD/NICHD NIH HHS/ -- P01 HD039691-07/HD/NICHD NIH HHS/ -- P01 HD039691-08/HD/NICHD NIH HHS/ -- R01 GM052359/GM/NIGMS NIH HHS/ -- R01 GM052359-10/GM/NIGMS NIH HHS/ -- R01 GM052359-11/GM/NIGMS NIH HHS/ -- R01 GM052359-12/GM/NIGMS NIH HHS/ -- R01 GM052359-13/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 3;317(5838):678-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17673666" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Separation ; Cytoplasmic Vesicles/metabolism ; Dictyostelium/cytology/*immunology/microbiology/physiology ; Ethidium/metabolism ; Fluorescent Dyes/metabolism ; Gene Expression ; Immunity, Innate ; Legionella pneumophila/*immunology ; Mutation ; Phagocytes/cytology/*immunology ; *Phagocytosis ; Protozoan Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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