ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Mice, Inbred C57BL  (2)
  • Models, Neurological  (2)
  • *Cell Lineage/drug effects  (1)
  • 1
    facet.materialart.
    Unknown
    Activation of specific interneurons improves V1 feature selectivity and visual perception (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-08-11
    Description: Inhibitory interneurons are essential components of the neural circuits underlying various brain functions. In the neocortex, a large diversity of GABA (gamma-aminobutyric acid) interneurons has been identified on the basis of their morphology, molecular markers, biophysical properties and innervation pattern. However, how the activity of each subtype of interneurons contributes to sensory processing remains unclear. Here we show that optogenetic activation of parvalbumin-positive (PV+) interneurons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perceptual discrimination. Using multichannel recording with silicon probes and channelrhodopsin-2 (ChR2)-mediated optical activation, we found that increased spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons. These effects were caused by the activation of inhibitory neurons rather than a decreased spiking of excitatory neurons, as archaerhodopsin-3 (Arch)-mediated optical silencing of calcium/calmodulin-dependent protein kinase IIalpha (CAMKIIalpha)-positive excitatory neurons caused no significant change in V1 stimulus selectivity. Moreover, the improved selectivity specifically required PV+ neuron activation, as activating somatostatin or vasointestinal peptide interneurons had no significant effect. Notably, PV+ neuron activation in awake mice caused a significant improvement in their orientation discrimination, mirroring the sharpened V1 orientation tuning. Together, these results provide the first demonstration that visual coding and perception can be improved by increased spiking of a specific subtype of cortical inhibitory interneurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422431/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422431/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Seung-Hee -- Kwan, Alex C -- Zhang, Siyu -- Phoumthipphavong, Victoria -- Flannery, John G -- Masmanidis, Sotiris C -- Taniguchi, Hiroki -- Huang, Z Josh -- Zhang, Feng -- Boyden, Edward S -- Deisseroth, Karl -- Dan, Yang -- PN2 EY018241/EY/NEI NIH HHS/ -- R01 EY018861/EY/NEI NIH HHS/ -- R01 NS067199/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Aug 16;488(7411):379-83. doi: 10.1038/nature11312.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22878719" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/deficiency/genetics/metabolism ; Discrimination Learning ; Interneurons/*physiology ; Mice ; Models, Neurological ; Neural Inhibition/physiology ; Parvalbumins/metabolism ; Rhodopsin/metabolism ; Rhodopsins, Microbial/metabolism ; Visual Cortex/*cytology/*physiology ; Visual Perception/*physiology ; Wakefulness/physiology ; gamma-Aminobutyric Acid/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Cortical interneurons that specialize in disinhibitory control (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-10-08
    Description: In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017628/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017628/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pi, Hyun-Jae -- Hangya, Balazs -- Kvitsiani, Duda -- Sanders, Joshua I -- Huang, Z Josh -- Kepecs, Adam -- R01 NS075531/NS/NINDS NIH HHS/ -- R01NS075531/NS/NINDS NIH HHS/ -- U01 MH078844/MH/NIMH NIH HHS/ -- U01MH078844/MH/NIMH NIH HHS/ -- England -- Nature. 2013 Nov 28;503(7477):521-4. doi: 10.1038/nature12676. Epub 2013 Oct 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24097352" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Animals ; Auditory Cortex/physiology ; Cerebral Cortex/*cytology/*physiology ; Discrimination (Psychology)/physiology ; Female ; Interneurons/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Inhibition/*physiology ; Optogenetics ; Parvalbumins/metabolism ; Prefrontal Cortex/physiology ; Punishment ; Reward ; Single-Cell Analysis ; Somatostatin/metabolism ; Vasoactive Intestinal Peptide/metabolism ; Wakefulness/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Presynaptic inhibition of spinal sensory feedback ensures smooth movement (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-05-03
    Description: The precision of skilled movement depends on sensory feedback and its refinement by local inhibitory microcircuits. One specialized set of spinal GABAergic interneurons forms axo-axonic contacts with the central terminals of sensory afferents, exerting presynaptic inhibitory control over sensory-motor transmission. The inability to achieve selective access to the GABAergic neurons responsible for this unorthodox inhibitory mechanism has left unresolved the contribution of presynaptic inhibition to motor behaviour. We used Gad2 as a genetic entry point to manipulate the interneurons that contact sensory terminals, and show that activation of these interneurons in mice elicits the defining physiological characteristics of presynaptic inhibition. Selective genetic ablation of Gad2-expressing interneurons severely perturbs goal-directed reaching movements, uncovering a pronounced and stereotypic forelimb motor oscillation, the core features of which are captured by modelling the consequences of sensory feedback at high gain. Our findings define the neural substrate of a genetically hardwired gain control system crucial for the smooth execution of movement.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292914/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292914/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fink, Andrew J P -- Croce, Katherine R -- Huang, Z Josh -- Abbott, L F -- Jessell, Thomas M -- Azim, Eiman -- MH078844/MH/NIMH NIH HHS/ -- MH093338/MH/NIMH NIH HHS/ -- NS033245/NS/NINDS NIH HHS/ -- R01 MH093338/MH/NIMH NIH HHS/ -- R01 NS033245/NS/NINDS NIH HHS/ -- R01 NS080932/NS/NINDS NIH HHS/ -- T32 HD007430/HD/NICHD NIH HHS/ -- U01 MH078844/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 May 1;509(7498):43-8. doi: 10.1038/nature13276.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA. ; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. ; Center for Theoretical Neuroscience, Departments of Physiology and Neuroscience, Columbia University, New York, New York 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24784215" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Efferent Pathways/physiology ; Feedback, Sensory/*physiology ; Female ; Forelimb/physiology ; GABAergic Neurons/cytology/metabolism ; Glutamate Decarboxylase/genetics/metabolism ; Interneurons/cytology/metabolism ; Male ; Mice ; Models, Neurological ; Motor Skills/*physiology ; Movement/*physiology ; Neural Inhibition/*physiology ; Neurotransmitter Agents/secretion ; Presynaptic Terminals/*physiology ; Spinal Cord/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-07-31
    Description: Adult neurogenesis arises from neural stem cells within specialized niches. Neuronal activity and experience, presumably acting on this local niche, regulate multiple stages of adult neurogenesis, from neural progenitor proliferation to new neuron maturation, synaptic integration and survival. It is unknown whether local neuronal circuitry has a direct impact on adult neural stem cells. Here we show that, in the adult mouse hippocampus, nestin-expressing radial glia-like quiescent neural stem cells (RGLs) respond tonically to the neurotransmitter gamma-aminobutyric acid (GABA) by means of gamma2-subunit-containing GABAA receptors. Clonal analysis of individual RGLs revealed a rapid exit from quiescence and enhanced symmetrical self-renewal after conditional deletion of gamma2. RGLs are in close proximity to terminals expressing 67-kDa glutamic acid decarboxylase (GAD67) of parvalbumin-expressing (PV+) interneurons and respond tonically to GABA released from these neurons. Functionally, optogenetic control of the activity of dentate PV+ interneurons, but not that of somatostatin-expressing or vasoactive intestinal polypeptide (VIP)-expressing interneurons, can dictate the RGL choice between quiescence and activation. Furthermore, PV+ interneuron activation restores RGL quiescence after social isolation, an experience that induces RGL activation and symmetrical division. Our study identifies a niche cell-signal-receptor trio and a local circuitry mechanism that control the activation and self-renewal mode of quiescent adult neural stem cells in response to neuronal activity and experience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438284/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438284/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Song, Juan -- Zhong, Chun -- Bonaguidi, Michael A -- Sun, Gerald J -- Hsu, Derek -- Gu, Yan -- Meletis, Konstantinos -- Huang, Z Josh -- Ge, Shaoyu -- Enikolopov, Grigori -- Deisseroth, Karl -- Luscher, Bernhard -- Christian, Kimberly M -- Ming, Guo-li -- Song, Hongjun -- AG040209/AG/NIA NIH HHS/ -- HD069184/HD/NICHD NIH HHS/ -- MH089111/MH/NIMH NIH HHS/ -- NS048271/NS/NINDS NIH HHS/ -- R01 AG040209/AG/NIA NIH HHS/ -- R01 HD069184/HD/NICHD NIH HHS/ -- R01 NS047344/NS/NINDS NIH HHS/ -- R01 NS048271/NS/NINDS NIH HHS/ -- R01 NS065915/NS/NINDS NIH HHS/ -- R21 ES021957/ES/NIEHS NIH HHS/ -- R56 NS047344/NS/NINDS NIH HHS/ -- England -- Nature. 2012 Sep 6;489(7414):150-4. doi: 10.1038/nature11306.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22842902" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Lineage/drug effects ; Cell Proliferation/drug effects ; Dentate Gyrus/cytology/drug effects/metabolism ; Female ; GABA Modulators/pharmacology ; GABA-A Receptor Agonists/pharmacology ; GABA-A Receptor Antagonists/pharmacology ; Interneurons/cytology/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/drug effects/*physiology ; Neural Stem Cells/*cytology/drug effects/metabolism ; *Neurogenesis/drug effects ; Neuroglia/cytology/drug effects/metabolism ; Parvalbumins/metabolism ; Receptors, GABA-A/metabolism ; Signal Transduction/drug effects ; Somatostatin/metabolism ; Stem Cell Niche/drug effects/physiology ; Vasoactive Intestinal Peptide/metabolism ; gamma-Aminobutyric Acid/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...