Publication Date:
1992-01-24
Description:
Spatial gradients of axon guiding molecules have long been suspected to provide positional and directional cues for retinal ganglion cell axons growing within the optic tectum. With the identification of a guiding activity from tectal cell membranes, it has become possible to investigate the potential physiological significance of molecular gradients for retinal growth cone behavior in vitro. A subset of retinal growth cones, those from the temporal half, were highly sensitive to small concentration changes of the guiding component. The degree of response was correlated with the strength of the gradient. These findings demonstrate that the neural growth cone can read gradients of surface-associated information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baier, H -- Bonhoeffer, F -- New York, N.Y. -- Science. 1992 Jan 24;255(5043):472-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1734526" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/*physiology
;
Cell Membrane/physiology
;
Chick Embryo
;
Culture Techniques
;
Retina/*cytology
;
Superior Colliculi/*physiology/ultrastructure
;
Visual Pathways/*cytology/embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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