Publication Date:
1991-10-11
Description:
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salgame, P -- Abrams, J S -- Clayberger, C -- Goldstein, H -- Convit, J -- Modlin, R L -- Bloom, B R -- AI-07118/AI/NIAID NIH HHS/ -- AI-20111/AI/NIAID NIH HHS/ -- AI-26491/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):279-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, NY 10461.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1681588" target="_blank"〉PubMed〈/a〉
Keywords:
Antibody Formation
;
*Antigens, CD4
;
*Antigens, CD8
;
CD4-Positive T-Lymphocytes/secretion
;
Clone Cells
;
Humans
;
Interferon-gamma/secretion
;
Interleukin-4/secretion
;
Interleukins/secretion
;
Leprosy/immunology
;
Lymphokines/*secretion
;
T-Lymphocyte Subsets/*secretion
;
T-Lymphocytes/secretion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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