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  • Earth Resources and Remote Sensing  (4)
  • Pentobarbital/*pharmacology  (4)
  • INSTRUMENTATION AND PHOTOGRAPHY  (3)
  • 1
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    Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    (-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Pentobarbital: dual actions to increase brain benzodiazepine receptor affinity (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: The binding of [3H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter gamma-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of [3H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [3H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these types of compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, P -- Moncada, V -- Barker, J L -- Paul, S M -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1448-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6258230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/drug effects ; Chlorides/metabolism ; Diazepam/metabolism ; Male ; Pentobarbital/*pharmacology ; Rats ; Receptors, Drug/*drug effects/metabolism ; Receptors, GABA-A ; Stimulation, Chemical ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: Stereoisomers of the barbiturate anesthetic pentobarbital were applied to mouse spinal neurons growing in tissue culture. Intracellular recordings of neuronal membrane properties revealed that the (+) and (-) isomers caused direct changes in membrane potential and conductance on some but not all of the cells tested. The action of the (+) isomer was predominantly excitatory, whereas the (-) isomer produced predominantly inhibitory responses. The (-) isomer was considerably more effective in potentiating inhibitory responses to the transmitter gamma-aminobutyric acid. The results show that pentobarbital has multiple effects on neuronal excitability and demonstrate the presence of stereospecific sites of barbiturate action on central neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, L Y -- Barker, J L -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350656" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Electric Conductivity ; Membrane Potentials/drug effects ; Mice ; Neural Inhibition/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Spinal Cord/embryology ; Stereoisomerism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Spectral Characterization of the LANDSAT-4 MSS Sensors (1984)
    In:  CASI
    Details
    Publication Date: 2014-09-17
    Description: Relative spectral response data for the LANDSAT-4 and LANDSAT-4 backup multispectral scanner subsystems (MSS), the protoflight and flight models are presented and compared to similar data for the LANDSAT 1, 2 and 3 scanners. Channel (six channels per band) outputs for soil and soybean targets were simulated and compared within each band and between scanners. The principal differences between the spectral responses of the LANDSAT-4 scanners and previous scanners are discussed. The simulated LANDSAT-4 scanner outputs were 3 to 10 percent lower in the red band and 3 to 11 percent higher in the first near-IR band than previous scanners for the soybeans targets. The LANDSAT-4 scanners were generally more uniform from channel to channel within bands than previous scanners. In the upper-band edge of the red band of the protoflight scanner, one channel was markedly different (12 nm) from the rest. For a soybeans target, this nonuniformity resulted in a within-band difference of 6.2 percent in simulated outputs between channels.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 2; p 73-75
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  • 6
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    Relative Radiometric Calibration of LANDSAT TM Reflective Bands (1984)
    In:  CASI
    Details
    Publication Date: 2014-09-12
    Description: The characterization of the relative radiometric calibration of the protoflight Thematic Mapper sensor (TM/PF) is considered with focus on the variability and uncertainty of TM relative radiometry, including total variability as well as its systematic and random components. Emphasis is placed on identifying the magnitude and types of systematic errors, since these have the potential for being reduced during ground processing. Estimates of innate random variability, such as the standard deviation of a signal or its signal to noise ratio, are also important. The processing effects of radiometry are explored. Recommendations are given for engineering characterization, flight segment operations and ground processing.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 1; p 140-180
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  • 7
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    Pre-launch Absolute Radiometric Calibration of LANDSAT-4 Protoflight Thematic Mapper (1984)
    In:  CASI
    Details
    Publication Date: 2014-09-12
    Description: From both scientific and applications perspectives, the usefulness of TM digital imagery is significantly determined by its radiometric characteristics. This includes both the accuracy to which the dynamic range is known and its radiometric reproducibility or precision. Results from several pre-launch tests with a 122-cm Integrating Sphere (IS) used as part of the absolute radiometric calibration experiments for the protoflight TM sensor carried on the LANDSAT-4 satellite are summarized and analyzed. Topics covered include TM radiometric calibration and sensitivity; the TM internal calibrator; and the dynamic range after calibration.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 1; p 130-139
    Format: text
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  • 8
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    Pre-Launch Noise Characterization of the Landsat-7 Enhanced Thematic Mapper Plus (ETM Plus) (1999)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: A noise characterization of the Landsat-7 Enhanced Thematic Mapper Plus (ETM+) instrument was performed as part of a near-real time performance assessment and health monitoring program. Perl'ormance data for the integrated Landsat-7 spacecraft and ETM+ were collected before, during, and after the spacecraft thermal vacuum testing program at the Lockheed Martin Missiles and Space (LMMS) facilities in Valley Forge, PA. The Landsat-7 spacecraft and ETM+ instrument were successfully launched on April 15, 1999. The spacecraft and ETM+ are now nearing the end of the on orbit engineering checkout phase, and Landsat-7 is expected to be declared operational on or about July 15, 1999. A preliminary post-launch noise characterization was performed and compared with the pre-launch characterization. In general the overall noise levels in the ETM+ are at or below the specification levels. Coherent noise is seen in most bands, but is only operationally significant when imaging in (he panchromatic band (band 8). This coherent noise has an amplitude as high as approximately 3 DN (peak-to-peak, high gain) at the Nyquist rate of 104 kHz, and causes the noise levels in panchromatic band images at times to exceed the total noise specification by up to approximately 10%. However, this 104 kHz noise is now much weaker than it was prior to the successful repair of the ETM+ power supplies that was completed in May 1998. Weak and stable coherent noise at approximately 5 kHz is seen in all bands in the prime focal plane (bands 1-4 and 8) with the prime (side A) electronics. Very strong coherent noise at approximately 20 kHz is seen in a few detectors of bands 1 and 8, but this noise is almost entirely in the turn-around region between scans when the ETM+ is not imaging the Earth. Strong coherent noise was seen in 2 detectors of band 5 during some of the pre-launch testing; however, this noise seems to be temperature dependent, and has not been seen in the current on orbit environment. Strong 91 kHz coherent noise was observed in the redundant (side B) panchromatic band data after the completion of spacecraft thermal vacuum testing. The cause of this coherent noise was identified as a failed capacitor that was replaced prior to launch, and this noise has not been seen on orbit.
    Keywords: Earth Resources and Remote Sensing
    Type: Jul 18, 1999 - Jul 23, 1999; Denver, CO; United States
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  • 9
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    Landsat 7: An Early Look at On-Orbit Performance (1999)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: As this article was being submitted in mid-March, 1999, Landsat 7 had been cleared for an official launch date of April 15, 1999, approximately 2 and 1/2 months prior to the 21st Canadian Symposium on Remote Sensing. Since it is impossible to discuss "early on-orbit performance" prior to the actual launch of the satellite, we have chosen to briefly summarize the major features of the Landsat 7 program. Additional information can be found at several web sites which will summarized at the end of this paper. At this time, the Landsat Project Science Office is pleased to report that the performance of the ETM+ instrument appears to be very good. In addition to excellent instrument performance, a robust data acquisition plan has been developed with the goal of acquiring and systematically refreshing a global archive of land observations at the EROS Data Center annually. A ground processing system is being implemented at EROS that will be capable of capturing, processing and archiving 250 Landsat scenes per day, and delivering 100 scene products to users daily. In addition, the cost of a systematically-processed Level 1 product will be less than $600, and there will be no copyright protection on the data. The net result is that the use of remote sensing data in our daily lives is expected to grow dramatically. This growth is expected to benefit all facets of the land remote sensing community.
    Keywords: Earth Resources and Remote Sensing
    Type: Airborne Remote Sensing; Jun 21, 1999 - Jun 24, 1999; Ottawa, Ontario; Canada|Remote Sensing; Jun 21, 1999 - Jun 24, 1999; Ottawa, Ontario; Canada
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  • 10
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    LANDSAT 7: Early on-Orbit Results (1999)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: As this article was being submitted in mid-March, 1999, Landsat 7 had been cleared for an official launch date of April, 15, 1999, approximately 4 - 5 weeks prior to the Portland ASPRS conference. Although it is hoped that the presentation in Portland will be the first public status report on the in-orbit performance of the Landsat 7 spacecraft and the ETM+ instrument, it is impossible to discuss "early on-orbit performance" prior to launch. Therefore, we have chosen to summarize the overarching salient features of the Landsat 7 program, and we will point to some web sites where additional information about the program can be found (e.g., http://geo.arc.nasa.gov/sge/landsat/landsat. html). At this time, the Landsat Project Science Office is pleased to report that the performance of the ETM+ instrument appears to be very good. In addition to excellent instrument performance, a robust data acquisition plan has been developed with the goal of acquiring a seasonally-refreshed archive of global land observations at the EROS Data Center annually. A ground processing system is being implemented at EROS that will be capable of capturing, processing and archiving 250 Landsat scenes per day, and delivering 100 scene products to users each day. The cost of a systematically-processed Level 1 product will be less than $600, and there will be no copyright protection on the data. The net result is that the use of remote sensing data in our daily lives is expected to grow dramatically. This growth is expected to benefit all facets of the land remote sensing community.
    Keywords: Earth Resources and Remote Sensing
    Type: May 17, 1999 - May 21, 1999; Portland, OR; United States
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