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  • 1
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    Inactivation of the phosphatidylinositol 3-kinase/Akt pathway is involved in BMP9-mediated tumor-suppressive effects in gastric cancer cells (2015)
    Wiley
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    Publication Date: 2015-01-06
    Description: Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily signaling factors. Expression of several BMPs (BMP2, BMP4 and BMP7) is correlated to poor prognosis in gastric cancer patients. The function of BMP9, the latest discovered and most powerful osteogenetic factor, in gastric cancer is relatively unclear. In this report, we investigated the expression, function and underlying molecular mechanisms of BMP9 in gastric cancer. The results show that BMP9 expression was markedly decreased in gastric cancer tissues and cell lines. Enforced BMP9 expression in the gastric cancer cell lines SGC-7901 and MNK-45 increased apoptosis and reduced viability and migration. The in vivo function of BMP9 was evaluated in a xenograft mouse model. Tumors derived from SGC-7901 cells with enforced BMP9 expression (SGC-7901/BMP9) showed significantly reduced size and weight compared to that from control cells. Enforced BMP9 expression resulted in decreased Akt activity shown as lower levels of phosphorylation at Ser473 and Thr308 in Akt. The PI3K/Akt inhibitor LY294002 potentiated BMP9's viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin. In addition, tumors derived from SGC-7901/BMP9 showed reduced Akt activity and VEGF expression, and increased E-cadherin expression. Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved in the tumor suppressor effects of BMP9 in gastric cancer. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 2
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    Cobalt(II) and Copper(II) Complexes Constructed from Bis(benzimidazole) and 2,6-Pyridinedicarboxylate Co-ligands: Synthesis, Crystal Structures, and Catalytic Properties (2015)
    Wiley
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    Publication Date: 2015-01-09
    Description: Three metal complexes based on the flexible bis(benzimidazole) derivatives, namely [Co 2 (L1) 4 (pydc) 2 ] · 2H 2 O ( 1 ), {[Cu(L1)(pydc)] · 0.75H 2 O} n ( 2 ), and [Co 2 (L2) 2 (pydc) 2 ] · 8H 2 O ( 3 ), [L1 = 1,2-bis(5,6-dimethylbenzimidazol-1-ylmethyl)benzene, H 2 pydc = 2,6-pyridinedicarboxylic acid, L2 = 1,4-bis(5-methylbenzimidazol-1-ylmethyl)benzene] were hydrothermally synthesized and characterized by IR spectra, elemental analysis, UV/Vis diffuse refraction spectroscopy, and X-ray single-crystal diffraction. Complexes 1 and 3 exhibit a dinuclear structure composed of two central cobalt atoms bridged by flexible bis(benzimidazole) ligands and 3 finally packed into a two-dimensional supramolecular network through π ··· π stacking interaction. Complex 2 shows a one-dimensional zigzag chains motif, which further extended into a 2D supramolecular layer by face-to-face π···π stacking interactions. The luminescence properties of complexes 1 – 3 in the solid state at room temperature were described. Moreover, complexes 1 and 2 show higher catalytic activity than complex 3 for degradation of congo red azo dye in a Fenton-like process.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley
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  • 3
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    Transition Metal Complexes with the Schiff Base Ligand 1-{[2-(2-Hydroxyethylamino)ethylimino]methyl}naphthalen-2-ol (2012)
    Wiley
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    Publication Date: 2012-12-01
    Description: Six transition metal compounds [Cu(H 2 L)(CH 3 COO)] · H 2 O ( 1 ), [Cu(H 2 L)(CH 3 COO)] ( 2 ), [Cu(H 2 L)](ClO 4 ) · CH 3 OH ( 3 ), 2[Cu(H 2 L) 2 ] ( 4 ), [Co(H 2 L) 2 ](NO 3 ) · 2CH 3 OH ( 5 ), and [Ni(H 2 L)](NO 3 ) ( 6 ) were synthesized by reactions of the Schiff base ligand H 3 L (1-{[2-(2-hydroxyethyl amino)ethylimino]methyl}naphthalen-2-ol) with the corresponding metal salts and characterized by single crystal X-ray diffraction, elemental analysis, IR and UV/Vis spectroscopy and TG analysis. All compounds are mononuclear molecules, in which the Schiff base ligand exhibits diverse coordination modes and conformations. The N–H ··· O, O–H ··· O, and C–H ··· O inter- and intramolecular hydrogen bonding interactions link these molecules into multidimensional network supramolecular structures.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
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  • 4
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    Modelling the vegetation response to the 8.2 ka bp cooling event in Europe and Northern Africa (2019)
    Wiley
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    Publication Date: 2019
    Description: ABSTRACT The 8.2 ka bp cooling event is assumed to be the most clearly marked abrupt climate event in the Holocene at northern mid‐ to high latitudes. In this study, we simulate the vegetation responses to the 8.2 ka bp climate change event over Europe and Northern Africa. Our results show that all dominant plant functional types (PFTs) over Europe and North Africa respond to these climate changes, but the magnitude, timing and impact factor of their responses are different. Compared with pollen‐based vegetation reconstructions, our simulation generally captures the main features of vegetation responses to the 8.2 ka bp event. Interestingly, in Western Europe, the simulated vegetation after perturbation is different from its initial state, which is consistent with two high‐resolution pollen records. This different vegetation composition indicates the long‐lasting impact of abrupt climate change on vegetation through eco‐physiological and ecosystem demographic processes, such as plant competition. Moreover, our simulations suggest a latitudinal gradient in the magnitude of the event, with more pronounced vegetation responses to the severe cooling in the north and weaker responses to less severe cooling in the south. This effect is not seen in pollen records.
    Print ISSN: 0267-8179
    Electronic ISSN: 1099-1417
    Topics: Geography , Geosciences
    Published by Wiley
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  • 5
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    Variational merged of hourly gauge-satellite precipitation in China: Preliminary results (2015)
    Wiley
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    Publication Date: 2015-08-27
    Description: The article describes a variational scheme for the analysis of high-resolution hourly precipitation from CMA gauges and NOAA CMORPH satellite products in China and tests their impact on data-sparse regions and the heavy rainfall occurrences during the summer season ( June-August, 2009). In the variational scheme, a cost function is defined to measure the distance between analyzed precipitation field and observed rainfall quantity. A recursive filter is incorporated into the cost function which helps spread the observations to nearby grid points. Then a quasi-Newton method is used to solve the optimal estimation problem by minimizing the cost function. The adjoint technique is used to derive the gradient of cost function with respect to analysis precipitation. A series of experiments are performed to inter-compare the variational analysis with the original CMORPH satellite products (CMP) and the bias-adjusted satellite products (Adj-CMP) against the observations. The best overall performance is from the variational analysis especially rainfall intensity by more than 10 mm hr -1 with a prevailing mean relative spatial bias nearly reduction zero and the correlation coefficient is almost around 0.5 in convection active areas. Ground Cross Validation experiments in which each affected station is withdrawal at once indicated that the variatoinal analysis can particularly be beneficial and subsequent investigation of heavy rainfall events. It also reveals that the precipitation analysis field has the ability to improve the accuracy of rainfall estimation and capture the spatial precipitation pattern agreements in relatively data-sparse regions.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    The Influence of MicroRNA-150 in Osteoblast Matrix Mineralization (2015)
    Wiley
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    Publication Date: 2015-07-26
    Description: This study investigated the influence of miR-150 expression on osteoblast matrix mineralization and its mechanisms. The mouse osteoblast cell line MC3T3-E1 was used as an in vitro model of bone formation. On the 5th day of mineralization, transfection experiments using agomiR-150, agomiR-NC, antagomiR-150 antagomiR-NC and mock groups were set up to test the effects of miR-150 in MC3T3-E1 model. The mRNA and protein levels of OC, ALP, Type I collagen and OPN were measured by qRT-PCR and ELISA. Matrix mineralization was detected by alizarin red S (ARS) staining and flow cytometry was employed to quantify apoptosis in each group. RT-PCR and western blot were applied to detect the expression of target gene MMP14 . Our results demonstrated that the endogenous expression levels of miR-150, OC, ALP, Type I collagen and OPN in MC3T3-E1 cells increased steadily. Exogenous expressions of agomiR-150 and antagomiR-150 can significantly up-/down-regulated, respectively, the expression level of miR-150 in MC3T3-E1 cells. Compared with the mock group, higher expression levels of OC, ALP, Type I collagen and OPN mRNA were observed in the agomiR-150 group, while lower mRNA expression levels of OC, ALP, Type I collagen and OPN were found in the antagomiR-150 group. Based on these results, potential miR-150 targeted genes are discussed. Our results showed that miR-150 supports the osteoblastic phenotype related to osteoblast function and bone mineralization. Thus, miR-150 may have potential therapeutic applications in promoting bone formation in certain disease settings, such as in osteoporosis and in elderly patients. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 7
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    ESRRB plays a crucial role in the promotion of porcine cell reprogramming (2017)
    Wiley
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    Publication Date: 2017-06-22
    Description: The estrogen-related receptor b (ESRRB) is an orphan nuclear receptor and targets many genes involved in self-renewal and pluripotency. In mouse ES cells, overexpression of ESRRB can maintain LIF-independent self-renewal in the absence of Nanog. However, the fundamental features of porcine ESRRB remain elusive. In this study, we revealed the expression profiles of ESRRB in both porcine pluripotent stem cells and early stage embryos and dissected the functional domains of ESRRB protein to prove that ESRRB is a key transcription factor that enhanced porcine pluripotent gene activation. Addition of ESRRB into the cocktail of core pluripotent factors Oct4, Sox2, Klf4, and c-Myc (OSKM + E) could significantly enhance the reprogramming efficiency and the formation of alkaline phosphatase positive colonies. Conversely, knockdown of ESRRB in piPSCs significantly reduced the expression level of pluripotent genes, minimized the alkaline phosphatase activity, and initiated the porcine induced pluripotent stem cell differentiation. Therefore, porcine ESRRB is a crucial transcription factor to improve the self-renewal of piPSCs. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
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  • 8
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    East Asian Study of Tropospheric Aerosols and their Impact on Regional Clouds, Precipitation, and Climate (EAST‐AIRCPC) (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Aerosols have significant and complex impacts on regional climate in East Asia. Cloud‐aerosol‐precipitation interactions (CAPI) remain most challenging in climate studies. The quantitative understanding of CAPI requires good knowledge of aerosols, ranging from their formation, composition, transport, as well as their radiative, hygroscopic, and microphysical properties. A comprehensive review is presented here centered on the CAPI based chiefly, but not limited to, publications in the special section named EAST‐AIRcpc concerning (1) observations of aerosol loading and properties; (2) relationships between aerosols and meteorological variables affecting CAPI; (3) mechanisms behind CAPI; and (4) quantification of CAPI and their impact on climate. Heavy aerosol loading in East Asia has significant radiative effects by reducing surface radiation, increasing the air temperature, and lowering the boundary layer height. A key factor is aerosol absorption, which is particularly strong in central China. This absorption can have a wide range of impacts such as creating an imbalance of aerosol radiative forcing at the top and bottom of the atmosphere, leading to inconsistent retrievals of cloud variables from space‐borne and ground‐based instruments. Aerosol radiative forcing can delay or suppress the initiation and development of convective clouds whose microphysics can be further altered by the microphysical effect of aerosols. For the same cloud thickness, the likelihood of precipitation is influenced by aerosols: suppressing light rain and enhancing heavy rain, delaying but intensifying thunderstorms, and reducing the onset of isolated showers in most parts of China. Rainfall has become more inhomogeneous and more extreme in the heavily polluted urban regions
    Print ISSN: 2169-897X
    Electronic ISSN: 2169-8996
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
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    Geochronology and geochemistry of late Mesozoic volcanic rocks in the Wenkutu area, Great Xing'an Range, China (2018)
    Wiley
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    Publication Date: 2018-05-17
    Print ISSN: 0072-1050
    Electronic ISSN: 1099-1034
    Topics: Geosciences
    Published by Wiley
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  • 10
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    The influence of MicroRNA-150 in Osteoblast Matrix Mineralization (2015)
    Wiley
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    Publication Date: 2015-10-08
    Print ISSN: 0730-2312
    Electronic ISSN: 1097-4644
    Topics: Biology , Chemistry and Pharmacology , Medicine
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