Publication Date:
2016-04-21
Description:
X-ray structures and mechanism of the human serotonin transporter Nature 532, 7599 (2016). doi:10.1038/nature17629 Authors: Jonathan A. Coleman, Evan M. Green & Eric Gouaux The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target for antidepressant and psychostimulant drugs, which block reuptake and prolong neurotransmitter signalling. Here we report X-ray crystallographic structures of human SERT at 3.15 Å
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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