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  • 1
    Keywords: Urban policy. ; Sustainability. ; Architecture. ; Urban Policy. ; Sustainability. ; Cities, Countries, Regions.
    Description / Table of Contents: Part 1: Tourism dynamics in urban city centres -- Towards resilient urbanism in tourist cities: post-pandemic challenges -- The pain of being a resident in Granada. Analysis of the accommodation offer and residents´ perception -- Recent socio-spatial transformations in the San Pedro neighbourhood (Santiago de Compostela) -- The touristification of historic centres through commercial gentrification in times of Covid-19 -- Citizen resistance in touristified neighborhoods. A post-pandemic análisis -- Neoliberalism, collaborative economy, and short-term rentals regulation in Andalusia, Spain -- Changes in the role of heritage in historic centres: the mutation of historic buildings into tourist accommodation -- Part 2: Urban-tourist spaces on the coast: New urbanised spaces and resistance -- Urban-tourism spaces on the coast: transformations, challenges and globalisation in uncertain scenarios -- Landscape preservation on the Mediterranean coast; do social movements play a decisive role? The case of the Costa Brava (Spain) -- The construction of sustainable territorial models in the aftermath of the Covid-19 pandemic: Lessons from medium-sized Mediterranean cities -- Housing change during the Covid-19 pandemic in the metropolitan areas of the Canary Island capitals (Spain) -- Two megaprojects – One city. Learning between large-scale urban development projects on Tenerife, Spain -- Touristification process in seaside destination inland: The case of Mallorca Island, Spain -- Part 3: Urban transformations: New dynamics, conflicts and challenges in a context of uncertainty -- Towards urban degrowth? Urban planning as a common thread of contradictory dynamics in cities -- Shrinking cities in Spain: Shrinking medium-sized cities in the 21st century. Depopulation and employment -- The peripheries of Spanish developmentalism. an enduring model of urban fragmentation -- Housing, a problem perpetuated over time in Spain. New initiatives to promote access to affordable housing in Madrid -- Residential expectations in a neoliberal perspective: A sociological view of social classes and the right to housing -- (Re)thinking gentrification processes. The place of religion -- Metropolitan spatial reconfiguration and the mobility transition: Sustainability challenges in the fragmented city -- Sustainability and urban development strategies: Ciudad Real -- Part 4: Postscript -- Intra-urban borders in border cities: The nationally interchangeable dynamics of urban centrality.
    Abstract: This book offers a unique perspective on urban processes affecting tourist spaces and city centres. Economic, social and environmental uncertainty has been commonplace since March 2019, when mobility slowed down across the globe. The COVID-19 pandemic accelerated trends that have been investigated in urban space for years. The incorporation of technologies, the expansion of tourism and the introduction of policies that in part want to advance sustainability are generating processes of reorganisation of territories that are driving changes. These changes will affect models of city, urbanism and society. This publication is directed to a wide spectrum of people interested in urban processes, tourism and social change in the context of the Post-Pandemic Covid-19. In particular, the book is aimed at researchers, undergraduate and postgraduate students, consultants, public administrations and the public interested in the recent challenges that are affecting developed and developing societies.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 103 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031360176
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 2
    Call number: AWI A13-98-0217
    Type of Medium: Monograph available for loan
    Pages: XIV, 283 S.
    ISBN: 0521580471
    Branch Library: AWI Library
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 48 (2003), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We have previously shown that the plasmid-encoded toxin (Pet) of enteroaggregative Escherichia coli produces cytotoxic and enterotoxic effects. Pet-intoxicated epithelial cells reveal contraction of the cytoskeleton and loss of actin stress fibres. Pet effects require its internalization into epithelial cells. We have also shown that Pet degrades erythroid spectrin. Pet delivery within the intestine suggests that Pet may degrade epithelial fodrin (non-erythroid spectrin). Here we demonstrate that Pet has affinity for α-fodrin (formally named αII spectrin) in vitro and in vivo and cleaves epithelial fodrin, causing its redistribution within the cells. When Pet has produced its cytoskeletal effects, fodrin is found in intracellular aggregates as membrane blebs. Pet cleaves recombinant GST-fodrin, generating two breakdown products of 37 and 72 kDa. Sequencing of the 37 kDa fragment demonstrated that the cleavage site occurred within fodrin's 11th repetitive unit between M1198 and V1199, in the calmodulin binding domain. Site-directed mutagenesis of these amino acids prevented fodrin degradation by Pet. Pet also cleaves epithelial fodrin from cultured Pet-treated cells. A mutant in the Pet serine protease motif was unable to cause fodrin redistribution or to cleave GST-fodrin. This is the first report showing cleavage of α-fodrin by a bacterial protease. Cleavage occurs in the middle of the calmodulin binding domain, which leads to cytoskeleton disruption.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Enteroaggregative Escherichia coli (EAEC) is an emerging cause of pediatric and adult travellers diarrhea. The mechanism by which EAEC induce diarrhea is not completely known. Two serine protease autotransporter proteins, named Pet and Pic have been identified in EAEC strains. Pet has enterotoxic and cytotoxic activities, while the role of Pic in pathogenesis may lie on its mucinolytic activity. Little is known about Pet and Pic biological activities in vivo. In this study the antibody responses against these autotransporter proteins in convalescent children is investigated. Fifteen (83%) children showed specific antibodies against Pet or Pic in their sera. IgG and IgM antibodies were the main isotype found. Specific antibodies against Pic, but not against Pet, were detected in sera from age-matched control group. These data show that specific anti-Pet and anti-Pic antibodies are produced during the course of a natural EAEC infection in children.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5036
    Keywords: microbial activity ; N availability ; soil organic matter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Terrestrial responses to increasing atmospheric CO2 are important to the global carbon budget. Increased plant production under elevated CO2 is expected to increase soil C which may induce N limitations. The objectives of this study were to determine the effects of increased CO2 on 1) the amount of carbon and nitrogen stored in soil organic matter and microbial biomass and 2) soil microbial activity. A tallgrass prairie ecosystem was exposed to ambient and twice-ambient CO2 concentrations in open-top chambers in the field from 1989 to 1992 and compared to unchambered ambient CO2 during the entire growing season. During 1990 and 1991, N fertilizer was included as a treatment. The soil microbial response to CO2 was measured during 1991 and 1992. Soil organic C and N were not significantly affected by enriched atmospheric CO2. The response of microbial biomass to CO2 enrichment was dependent upon soil water conditions. In 1991, a dry year, CO2 enrichment significantly increased microbial biomass C and N. In 1992, a wet year, microbial biomass C and N were unaffected by the CO2 treatments. Added N increased microbial C and N under CO2 enrichment. Microbial activity was consistently greater under CO2 enrichment because of better soil water conditions. Added N stimulated microbial activity under CO2 enrichment. Increased microbial N with CO2 enrichment may indicate plant production could be limited by N availability. The soil system also could compensate for the limited N by increasing the labile pool to support increased plant production with elevated atmospheric CO2. Longer-term studies are needed to determine how tallgrass prairie will respond to increased C input.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Analysis of the initial interaction betweenEntamoeba histolytica trophozoites and the large intestine is impossible in humans and very difficult in experimental animals. To circumvent this obstacle we treated the luminal side of full-thickness rabbit colon segments mounted in Ussing-type chambers with trophozoite lysates of theE. histolytica HM1 virulent strain. Exposure to lysates for up to 90 min produced dose- and time-dependent effects on the colon, consisting of (a) increased decay rates for potential difference, short-circuit current, and transmural resistance and (b) mucosal damage ranging from vacuolation at the bases and shortening of epithelial cells to the loss of intercellular junctions, destruction of microvilli, and necrosis of interglandular epithelial zones. This acute model of intestinal amebiasis is sensitive, fast, and reliable.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract   One of the main drawbacks of experimental amebiasis is the lack of an adequate animal model for invasive intestinal lesions. Mongolian gerbils are useful because both intestinal and hepatic amebiasis can be produced experimentally with Entamoeba histolytica trophozoites. In this paper we show results obtained with in vivo and in vitro models of intestinal amebiasis in gerbils. We inoculated gerbils intracecally with monoxenic cultures of a highly virulent E. histolytica HM1:IMSS substrain. In the in vivo model an increase in mucus production was observed during the first 6 h of interaction. Microulcerative mucosal lesions appeared at 24–72 h postinoculation. Inflammatory infiltrate and edema of the lamina propria were associated with superficial foci of necrosis. At 96 h the cecal mucosa had an almost normal appearance and live amebas were no longer detected. In the in vitro model, early damage was detected in cecal strips mounted in Ussing chambers as a rapid fall in potential difference, short-circuit current, and transepithelial resistance that correlated with the extent of the microscopic lesions produced. The latter consisted of cellular edema and the appearance of small, translucent vacuoles at the base of epithelial cells. Further damage led to loss of intercellular junctions, destruction of interglandular epithelial cells, and edema of the lamina propria. The present results demonstrate that the gerbil is useful as an experimental model for the analysis of early stages of invasive intestinal amebiasis both in vivo and in vitro.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0730-2312
    Keywords: Aneuploidy ; biomarkers ; breast cancer ; dysplasia ; epidermal growth factor receptor ; estrogen receptor ; fine needle aspirates ; HER-2 ; high-risk ; hyperplasia ; p53 ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Fine needle aspirates (FNA) from 106 high-risk women and 25 low-risk women were evaluated for overexpression of estrogen receptor (ER), epidermal growth factor receptor (EGFR), mutant p53, and HER-2/neu by immunocytochemistry, and for aneuploidy by image analysis. Aspirates were also classified cytologically as normal, apocrine metaplasia, epithelial hyperplasia (EH), or dysplasia. High-risk women were those with a first-degree relative with breast cancer (76%), precancerous breast disease (26%), prior cancer of the contralateral breast (9%), or multiple abnormalities (11%). Low-risk women had none of the above risk factors, nor a prior breast biopsy or clinical evidence of fibrocystic disease. The median 10-year Gail risk for the high-risk group was 4%, compared to 0.7% for the low-risk group. There were significant differences (p 〈 0.01) between high- and low-risk women in the prevalences of hyperplasia (55% versus 12%), dysplasia (19% versus 0%), aneuploidy (32% versus 0%), overexpressed EGFR (32% versus 4%), and overexpressed p53 (29% versus 4%). The prevalence of multiple biomarker abnormalities was also greater in high-risk than in low-risk women (28% versus 0%; p 〈 0.01). Four percent (4%) of FNAs from high-risk women with normal cytology, 29% of aspirates with hyperplastic cytology, and 60% of those with dysplasia were associated with two or more biomarker abnormalities. The differences in the prevalence of multiple biomarker abnormalities among various cytologic categories were statistically significant (p = 0.02, normal versus EH; p = 0.02, EH versus dysplasia; p 〈 0.01, normal versus dysplasia). Further study of these tissue biomarkers as potential intermediate-term (5-10 year) predictors of breast cancer development is warranted.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2018-11-19
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: report , doc-type:report
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  • 10
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