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  • 1
    Publication Date: 2001-10-01
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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  • 2
    Publication Date: 2003-03-20
    Print ISSN: 1437-3254
    Electronic ISSN: 1437-3262
    Topics: Geosciences
    Published by Springer
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 691-696 
    ISSN: 1476-5535
    Keywords: Keywords: Haematococcus pluvialis; mixotrophic culture; light irradiance; astaxanthin production; kinetic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: High cell density cultivation of Haematococcus pluvialis for astaxanthin production was carried out in batch and fed-batch modes in 3.7-L bioreactors with stepwise increased light intensity control mode. A high cell density of 2.65 g L−1 (batch culture) or 2.74 g L−1 (fed-batch culture) was obtained, and total astaxanthin production in the fed-batch culture (64.36 mg L−1) was about 20.5% higher than in the batch culture (53.43 mg L−1). An unstructured kinetic model to describe the microalga culture system including cell growth, astaxanthin formation, as well as sodium acetate consumption was proposed. Good agreement was found between the model predictions and experimental data. The models demonstrated that the optimal light intensity for mixotrophic growth of H. pluvialis in batch or fed-batch cultures in a 3.7-L bioreactor was 90–360 μmol m−2 s−1, and that the stepwise increased light intensity mode could be replaced by a constant light intensity mode.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 21 (1998), S. 283-288 
    ISSN: 1476-5535
    Keywords: Keywords: Spirulina platensis; mixotrophic culture; light irradiance; phycocyanin production; kinetic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Phycocyanin production by high cell density cultivation of Spirulina platensis in batch and fed-batch modes in 3.7-L bioreactors with a programmed stepwise increase in light intensity program was investigated. The results showed that the cell density in fed-batch culture (10.2 g L−1) was 4.29-fold that in batch culture (2.38 g L−1), and the total phycocyanin production in the fed-batch culture (0.795 g L−1) was 3.05-fold that in the batch culture (0.261 g L−1). An unstructured kinetic model to describe the microalga culture system including cell growth, phycocyanin formation, as well as glucose consumption was proposed. The data fitted the models well (r 2 〉 0.99). Furthermore, based on the kinetic models, the potential effects of light limitation and photoinhibition on cell growth and phycocyanin formation can be examined in depth. The models demonstrated that the optimal light intensity for mixotrophic growth of Spirulina platensis in batch or fed-batch cultures using a 3.7-L bioreactor was 80160 μE m−2 s−1, and the stepwise increase in light intensity can be replaced by a constant light intensity mode.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 508-513 
    ISSN: 1476-5535
    Keywords: Keywords: microalgae; Crypthecodinium cohnii; salinity; fatty acid composition; docosahexaenoic acid; heterotrophic production
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The effects of salinity on cell growth and docosahexaenoic acid (DHA) content of three marine microalgal strains, Crythecodinium cohnii ATCC 30556, C. cohnii ATCC 50051 and C. cohnii RJH were investigated. The lag phases of the three strains increased with increasing salinity in Porphyridium medium. The specific growth rate of C. cohnii ATCC 30556 was the highest at 9 g L−1 NaCl while the other two strains had their highest specific growth rates at 5 g L−1 NaCl. The highest cell dry weight concentrations of 2.51 g L−1 and 1.56 g L−1 were achieved at 9 g L−1 NaCl for C. cohnii ATCC 30556 and ATCC 50051, respectively, while the highest dry weight concentration of 2.49 g L−1 was achieved at 5 g L−1 NaCl for C. cohnii RJH. The highest cell growth yield coefficient on glucose was 0.5 g g−1 for both C. cohnii ATCC 30556 and C. cohnii RJH and 0.45 g g−1 for C. cohnii ATCC 50051. All three strains responded to the change of salinity by modifying their cellular fatty acid compositions. At 9 g L−1 NaCl, C. cohnii ATCC 30556 had the highest total fatty acid content and DHA (C22:6) proportion. In contrast, C. cohnii ATCC 50051 and C. cohnii RJH had the highest DHA content at 5 g L−1 NaCl. C. cohnii ATCC 30556 and ATCC 50051 had the highest DHA yield (131.55 and 68.24 mg L−1 respectively) at 9 g L−1 NaCl while C. cohnii RJH had the highest DHA yield (128.83 mg L−1) at 5 g L−1 NaCl.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 503-507 
    ISSN: 1476-5535
    Keywords: Keywords: Chlorella protothecoides; heterotrophic culture; lutein production; unstructured kinetic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Production of lutein by the green microalga Chlorella protothecoides grown heterotrophically in a fermentor using glucose as the carbon source and urea as the nitrogen source was investigated. An unstructured kinetic model was proposed to describe the microalgal culture system including cell growth, lutein formation, as well as glucose and nitrogen consumption. The inhibition potentials of biomass, product and substrates on growth and lutein formation were examined and incorporated into the kinetic model. Values of the kinetic model parameters were estimated. The resulting model predictions were in good agreement with the experimental results. The model can be helpful in scale-up, optimization and control of the C. protothecoides culture process, and can also be used as a guideline for similar microalgal cultivation systems.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 22 (1999), S. 133-138 
    ISSN: 1476-5535
    Keywords: Keywords: Salvia miltiorrhiza; Lamiaceae; Agrobacterium rhizogenes; hairy roots; lithospermic acid B; rosmarinic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Hairy root cultures of Salvia miltiorrhiza were established by infecting sterile plantlets with Agrobacterium rhizogenes ATCC 15834, and the transformation was proved by direct detection of the inserted T-DNA by the polymerase chain reaction. As determined by HPLC, these hairy root cultures had the ability to produce lithospermic acid B (LAB), rosmarinic acid (RA) and other related phenolic compounds, the water-soluble active components of the plant. The effect of five different basal media, MS, MS-NH〈INF〉4〈/INF〉 (MS without ammonium nitrate), B5, WPM and 6,7-V on the root growth and phenolic compound production was studied. It was found that MS-NH〈INF〉4〈/INF〉 and 6,7-V media were superior to MS, B5 and WPM media in terms of both root growth and phenolic compound production. The time course of biomass accumulation and phenolic compound formation was also examined in the culture using MS-NH〈INF〉4〈/INF〉medium. During cultivation, the content of RA in the roots was stable being approximately 0.48% of dry weight while the content of LAB fluctuated between 0.73% and 1.61% of dry weight, and decreased gradually at the stationary phase of growth. The highest production of LAB and RA was about 64 mg L−1 and 23 mg L−1, respectively.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 7 (1996), S. 441-455 
    ISSN: 1572-8145
    Keywords: Flexible manufacturing systems ; FMS control ; survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Flexible manufacturing systems (FMS) have been developed with the hope that they would provide a means to tackle a threefold challenge — better quality, lower cost and shorter lead times — by integrating machine tools, robots, material handling and storage systems, and computers. Control of the integrated system presented a new set of problems as well as challenges, which have been receiving considerable attention from the academic community as well as from industrial system users. Intelligent control, which involves using computers to assist in decision making at various stages of the control process, has been advocated by many researchers as a possible avenue to reach a solution to these problems. This paper provides a review of the state of the art in intelligent control of FMS, in an attempt to supplement earlier general reviews via a more focused perspective. The principles of several techniques, namely simulation, knowledge based, example based, petri nets, and hybrid approaches are briefly introduced, and publications are reviewed, followed by discussions ontheir potential. Suggestions for further research and development are also enumerated.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 10 (1999), S. 405-421 
    ISSN: 1572-8145
    Keywords: Flexible manufacturing systems control ; intelligent manufacturing ; neural networks ; simulation ; material handling systems ; automated guided vehicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents a framework of intelligent manufacturing scheduling and control with specific applications to operations of rail-guided vehicle systems (RGVS). A RGVS control architecture is discussed with a focus on a simulated experiment in operations of the load/unload area of a real industrial flexible manufacturing system (FMS). In the operation stage of a material handling system (MHS), all shop floor data are subject to change as time goes. These data can be collected using a data acquisition device and stored in a dynamic database. The RGVS simulator used in this experimental study is designed to incorporate some possible situations representing existing material handling scenarios in order to evaluate alternative control policies. At the development stage of the controller, all possible combinations of most commonly encountered scenarios such as RGV failures, production schedule changes, machine breakdowns, and rush orders are to be simulated and corresponding results collected. The data are then structured into training data pairs to properly train an artificial neural network. The neural network, trained by using input/output data sets obtained from a number of simulation runs, will then provide control strategy recommendations. At the application stage, whenever an abnormal scenario occurs, a pre-processor will be activated to pre-screen and prepare an input vector for the trained neural network. If such an abnormal scenario falls outside the existing domain of data sets employed to train the neural network, as judged by the MHS supervisory controller, an off-line training module will be activated to eventually update the neural network. The recommended control strategies will be transmitted to the MHS control for real-time execution. If there is no further abnormal event detected, the dynamic data base (DDB) module simply continues to monitor the MHS activities. The proposed MHS control system combines the features of example based neural network technology and simulation modeling for true intelligent, on-line, pseudo real-time control. Not only will the system assure that feasible material handling control actions be taken, but also it will implement better control decisions through continuous learning from experiences captured as the operation time of the MHS accumulates.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 6 (1995), S. 175-190 
    ISSN: 1572-8145
    Keywords: Concurrent engineering ; cell design ; cell control ; simulation ; knowledge-based expert system ; neural networks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract One of the major thrusts of ‘agile/lean/responsive’ manufacturing strategies of the twentyfirst century is to introduce advanced information technology into manufacturing. This paper presents a framework for robust manufacturing system design with the integration of simulation, neural networks and knowledge-based expert system tools. An operation/ cost-driven cell design methodology was applied to concurrently consider cell physical design and the complexity of cell control functions. Simulation was exercised to estimate performance measures based on input parameters and given cell configurations. A rulebased expert system was employed to store the acquired expert knowledge regarding the relation between cell control complexities, cost of cell controls, performance measures and cell configuration. Neural networks were applied to predict the cell design configuration and corresponding complexities of cell control functions. Training of neural networks was performed with both forward and backward methods by using the same pair of data sets. Hence, trained neural networks will be able to predict either input or output parameters. This innovative new design methodology was illustrated via a successful implementation exercise resulting in actually acquiring an automated cell at industrial settings. The experience learned from this exercise indicates that the proposed design methodology works well as an effective decision support system for cell designers and the management in determining appropriate cell configuration and cell control functions at the design stage.
    Type of Medium: Electronic Resource
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