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  • shed snake skin  (2)
  • black rat snake  (1)
  • interaction
  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1042-1047 
    Details
    ISSN: 1573-904X
    Keywords: skin penetration ; transdermal ; shed snake skin ; functional group contribution ; Azone ; Elaphe obsoleta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The potential usefulness of shed snake skin as a model membrane for transdermal research was examined. There are similarities between shed snake skin and human stratum corneum in terms of structure, composition, lipid content, water permeability, etc. The permeability of various compounds and the contribution of several functional groups to the permeability were also found to be similar between shed snake skin and human skin. Moreover, the permeability of compounds through shed snake skin was increased by Azone, one of the most extensively studied transdermal penetration enhancers. Considering the similarities between shed snake skin and human skin, ease of storage and handling, and low cost, shed snake skin may offer a good model membrane for transdermal research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015943200982
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  • 2
    Electronic Resource
    Electronic Resource
    A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1302-1306 
    Details
    ISSN: 1573-904X
    Keywords: skin penetration ; shed snake skin ; Elaphe obsoleta ; black rat snake ; distribution coefficient ; molecular weight ; permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Penetration of various compounds through shed snake skin was measured in vitro to examine the effect of lipophilicity and molecular size of a compound on permeability through this model membrane. The permeabilities were found to be controlled by the lipophilicity and the molecular size of the permeant. The smaller and the more lipophilic the compound, the greater the permeability. Equations have been developed to predict the permeability from the molecular weight and the distribution coefficient of a compound. Further, the lipophilicity of shed snake skin is similar to that of human skin and the response of shed snake skin to the molecular size of a permeant is more similar to human skin than to hairless mouse skin. Considering the similarities between shed snake skin and human stratum coraeum in terms of structure, composition, and permeability characteristics, the same considerations may apply to permeability through human stratum corneum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015902308676
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    Paper (German National Licenses)
    Fulltext
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